本文選題：金黃色葡萄球菌 + 耐甲氧西林金黃色葡萄球菌��； 參考：《中國(guó)感染控制雜志》2017年09期

【摘要】：目的了解四川省金黃色葡萄球菌對(duì)萬(wàn)古霉素、利奈唑胺耐藥情況,為臨床抗感染治療提供參考依據(jù)。方法收集四川省71所醫(yī)院2011—2015年臨床分離的金黃色葡萄球菌、耐甲氧西林金黃色葡萄球菌(MRSA),并計(jì)算每年萬(wàn)古霉素與利奈唑胺對(duì)金黃色葡萄球菌、MRSA的最低抑菌濃度(MIC)值。結(jié)果 5年共收集51 976株金黃色葡萄球菌,包括MRSA14 361株,MRSA檢出率由2011年的36.02%下降至2015年的25.56%,呈下降趨勢(shì)(χ2=160.72,P0.05)。2011—2015年萬(wàn)古霉素對(duì)金黃色葡萄球菌的MIC50值分別為:1、0.5、0.5、1、1μg/mL,MIC90值由1μg/mL上升至2μg/mL;利奈唑胺MIC50值均為2μg/mL,MIC90值由2μg/mL上升至4μg/mL。2011—2015年萬(wàn)古霉素對(duì)MRSA的MIC50、MIC90值變化較明顯,分別由0.5、1μg/mL上升至2μg/mL;利奈唑胺MIC50值均為2μg/mL,MIC90值由2μg/mL上升至4μg/mL。結(jié)論 MRSA的檢出率有下降趨勢(shì),但萬(wàn)古霉素、利奈唑胺對(duì)其MIC50及MIC90值總體有上升趨勢(shì),需繼續(xù)加強(qiáng)細(xì)菌耐藥監(jiān)測(cè),為臨床合理應(yīng)用抗菌藥物提供幫助。
[Abstract]:Objective to investigate the resistance of Staphylococcus aureus to vancomycin and linazolamide in Sichuan Province and to provide reference for clinical anti-infection therapy. Methods Staphylococcus aureus and methicillin-resistant Staphylococcus aureus were collected from 71 hospitals in Sichuan Province from 2011 to 2015, and the minimum inhibitory concentrations (MIC) of vancomycin and linazolamide on MRSA were calculated. Results A total of 51 976 strains of Staphylococcus aureus were collected in 5 years. The positive rate of vancomycin to Staphylococcus aureus decreased from 36.02% in 2011 to 25.56% in 2015 (蠂 ~ 2 / 160.72 ~ (2) P 0.05). The MIC50 value of vancomycin to Staphylococcus aureus from 2011 to 2015 was 1: 1 0.50.55 渭 g / mL MIC90 from 1 渭 g/mL to 2 渭 g / mL; the MIC50 value of linazolamine increased from 2 渭 g / mL to 2 渭 g 路mL ~ (-1) from 1 渭 g / mL to 1 渭 g / mL, respectively, and the MIC50 value of vancomycin to Staphylococcus aureus increased from 1 渭 g/mL to 2 渭 g / mL in 2011-2015. From 4 渭 g/mL.2011-2015 to 4 渭 g/mL.2011-2015, the MIC90 value of vancomycin on MRSA was significantly changed. From 0.5 渭 g/mL to 2 渭 g / mL, the MIC50 value of linazolamide was 2 渭 g / mL, respectively, and the MIC90 value increased from 2 渭 g/mL to 4 渭 g / mL. Conclusion the detection rate of MRSA has a downward trend, but vancomycin and linazolamide have a general upward trend of MIC50 and MIC90 values. It is necessary to continue to strengthen the monitoring of bacterial resistance to provide help for the rational use of antimicrobial agents in clinic.
【作者單位】： 四川省醫(yī)學(xué)科學(xué)院四川省人民醫(yī)院;
【分類(lèi)號(hào)】：R446.5

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