本文選題：脂質(zhì)納泡 + 黑色素�。� 參考：《中國醫(yī)學(xué)影像技術(shù)》2017年10期

【摘要】：目的制備一種包載黑色素的多模態(tài)脂質(zhì)納泡(MNBs)造影劑,觀察其體外超聲、光聲、MR顯影效果。方法采用三氯甲烷注入—冷凍干燥—全氟丙烷充氣法制備MNBs和普通脂質(zhì)納泡(NBs),檢測MNBs的一般特性(形態(tài)、粒徑、黑色素裝載量、穩(wěn)定性),對不同濃度MNBs進(jìn)行體外超聲、光聲、MR成像并進(jìn)行定量對比分析。結(jié)果 MNBs形態(tài)規(guī)則,粒徑分布均勻,透射電鏡顯示MNBs成功包裹黑色素顆粒。黑色素的載藥量為90.53μg/mg。體外顯影實(shí)驗示隨MNBs和NBs濃度的增加,超聲造影效果明顯增強(qiáng),MNBs和NBs的超聲造影表現(xiàn)無明顯差異,相對信號強(qiáng)度差異無統(tǒng)計學(xué)意義(P0.05);隨MNBs濃度的增加,光聲和MRI顯影效果增強(qiáng),NBs無光聲和MRI顯影效果。結(jié)論成功制備出一種包載黑色素的多模態(tài)脂質(zhì)納泡造影劑,可明顯增強(qiáng)超聲、光聲、MR顯影效果。
[Abstract]:Objective to prepare MNBs- MNBs- containing melanin and observe the effect of in vitro ultrasound and photoacoustic Mr imaging of MNBs. Methods MNBs and ordinary lipids were prepared by chloroform injection, freeze-drying and perfluoropropane aeration. The general characteristics of MNBs (morphology, particle size, melanin loading, stability) were detected. In vitro ultrasound was carried out on different concentrations of MNBs. Mr imaging and quantitative contrast analysis were performed. Results the morphology of MNBs was regular and the particle size distribution was uniform. Transmission electron microscopy showed that MNBs successfully encapsulated melanin granules. The drug load of melanin was 90.53 渭 g / mg. In vitro imaging experiments showed that with the increase of MNBs and NBs concentration, there was no significant difference in contrast-enhanced performance between MNBs and NBs, and there was no significant difference in relative signal intensity (P 0.05) with the increase of MNBs concentration. The effect of photoacoustic and MRI enhancement was enhanced. Conclusion A multimodal lipid foam contrast agent containing melanin was successfully prepared, which can obviously enhance the development effect of ultrasound and photoacoustic Mr.
【作者單位】： 重慶醫(yī)科大學(xué)附屬兒童醫(yī)院超聲科兒童發(fā)育疾病研究教育部重點(diǎn)實(shí)驗室兒童發(fā)育重大疾病國家國際科技合作基地兒科學(xué)重慶市重點(diǎn)實(shí)驗室;重慶醫(yī)科大學(xué)超聲分子影像研究所重慶市超聲分子影像重點(diǎn)實(shí)驗室;重慶市腫瘤醫(yī)院超聲科重慶市腫瘤研究所重慶市癌癥中心;重慶醫(yī)科大學(xué)超聲醫(yī)學(xué)工程研究所;
【基金】：國家自然科學(xué)基金項目(81571688、81401503、81771845) 中國博士后特別資助項目(2015T80963) 重慶市博士后科研項目特別資助(Xm2014052、Xm2015089)
【分類號】：R445.1

【相似文獻(xiàn)】

相關(guān)期刊論文 前1條

1 佟正灝;王榮福;;多模態(tài)影像技術(shù)在臨床中的應(yīng)用進(jìn)展[J];CT理論與應(yīng)用研究;2014年04期

相關(guān)碩士學(xué)位論文 前2條

1 張華平;基于多模態(tài)信號的人體靜態(tài)平衡能力評估研究[D];杭州電子科技大學(xué);2016年

2 曾琪;多模態(tài)超聲對乳腺病變診斷的效能研究[D];廣西醫(yī)科大學(xué);2017年

，

本文編號：1869502