本文選題：褪黑素 + 膿毒血癥��； 參考：《東南大學學報(醫(yī)學版)》2017年03期

【摘要】：目的:通過檢測膿毒血癥患者褪黑素水平,探討其與病情嚴重程度、炎癥相關指標和死亡率的相關性。方法:收入膿毒血癥患者64例,采集其臨床信息和血清樣品。根據(jù)第30天生存與否將患者分為生存組(43例)和死亡組(21例)。應用酶聯(lián)免疫吸附(ELISA)法檢測血清褪黑素、干擾素-γ(IFN-γ)及白介素-4(IL-4)水平。結果:血清褪黑素水平生存組為(13.19±0.807)pg·ml~(-1),死亡組為(18.53±1.257)pg·ml~(-1),兩組間差異有統(tǒng)計學意義(P0.001)。褪黑素水平15 pg·ml~(-1)患者的30 d生存率顯著低于褪黑素水平15 pg·ml~(-1)者(P=0.002),且褪黑素水平是30 d死亡率的獨立危險因子(P=0.001)。褪黑素水平與膽紅素、乳酸、序貫器官衰竭估計(SOFA)評分、急性生理與慢性健康Ⅱ(APACHEⅡ)評分及IL-4評分呈顯著正相關,與住院時間及機械通氣天數(shù)呈顯著負相關。結論:膿毒血癥患者的褪黑素水平是死亡率的獨立危險因子,對其檢測有較高的臨床應用價值。
[Abstract]:Objective: to investigate the correlation of melatonin level with severity of disease, inflammation related index and mortality rate in patients with sepsis. Methods: clinical information and serum samples were collected from 64 patients with sepsis. Patients were divided into survival group (n = 43) and death group (n = 21). Serum melatonin, interferon- 緯 (IFN- 緯) and interleukin-4 (IL-4) were detected by Elisa. Results: the serum melatonin level in survival group was 13.19 鹵0.807)pg / ml ~ (-1) and that in death group was 18.53 鹵1.257)pg / ml ~ (-1). The difference between the two groups was statistically significant (P 0.001). The 30-day survival rate of patients with melatonin level (15 PG / ml) was significantly lower than that of patients with melatonin level (15 PG / ml -1), and melatonin level was an independent risk factor for 30 day mortality. The level of melatonin was positively correlated with bilirubin, lactic acid, sequential organ failure estimation score, acute physiology and chronic health 鈪，

本文編號：1834438