本文選題：肺腫瘤 + 活組織檢查�。� 參考：《中國臨床醫(yī)學(xué)影像雜志》2017年07期

【摘要】：目的:探討動態(tài)增強磁共振(DCE-MRI)掃描定量參數(shù)測定對鑒別肺部腫塊良惡性的可行性。方法:77例肺部腫塊患者行3.0T MR動態(tài)增強掃描,并經(jīng)手術(shù)或穿刺活檢病理證實,測量定量參數(shù):容量轉(zhuǎn)移常數(shù)(K~(trans))、速率常數(shù)(K_(ep))和血管外細(xì)胞外間隙容積比(v_e),分別對良性病變、惡性病變定量參數(shù)值進行統(tǒng)計學(xué)分析;最后繪制ROC曲線。結(jié)果 :惡性病變組:低分化腺癌K~(trans)、K_(ep)、v_e均值分別為(0.270±0.089)min~(-1)、(0.926±0.475)min~(-1)、0.340±0.144,低分化鱗癌分別為(0.268±0.066)min~(-1)、(0.997±0.464)min~(-1)、0.293±0.091,小細(xì)胞癌均值為(0.238±0.074)min~(-1)、(0.617±0.369)min~(-1)、0.412±0.312;良性病變組K~(trans)、K_(ep)、v_e均值分別為(0.190±0.084)min~(-1)、(0.569±0271)min~(-1)、0.392±0.207。良、組行獨立樣本t檢驗,K~(trans)、K_(ep)值均有統(tǒng)計學(xué)差異(P值均0.05),v_e值無統(tǒng)計學(xué)差異(P值0.05),良性病灶組分別與低分化腺癌、低分化鱗癌組行成組設(shè)計方差分析,K~(trans)及K_(ep)差異均有統(tǒng)計學(xué)意義(P值均0.05),v_e均無統(tǒng)計學(xué)差異(P值均0.05);低分化腺癌與低分化鱗癌K~(trans)、K_(ep)、v_e差異均無統(tǒng)計學(xué)意義(P值均0.05)。良性病灶組及惡性病灶組ROC曲線下面積分別為0.741、0.715,敏感性分別為88.4%、39.5%;特異性分別為54.2%、95.8%。結(jié)論 :DCE-MRI定量參數(shù)K~(trans)、K_(ep)值鑒別診斷肺部腫塊具有可行性,有助于對肺癌及肺部良性病灶進行鑒別。
[Abstract]:Objective: to investigate the feasibility of dynamic contrast enhanced magnetic resonance imaging (DCE-MRI) quantitative parameters in differentiating benign and malignant pulmonary masses. Methods 77 patients with pulmonary mass underwent dynamic contrast enhanced 3.0T Mr scan, confirmed by operation or biopsy and pathology. Quantitative parameters were measured: volume transfer constant, rate constant, and extracellular space volume ratio, respectively, for benign lesions. The quantitative parameters of malignant lesions were analyzed statistically. Finally, ROC curves were drawn. 緇撴灉 :鎭舵，

本文編號：1815502