發(fā)布時(shí)間：2018-04-27 00:22

  本文選題：氣單胞菌 + 耐藥性�。� 參考：《中國感染與化療雜志》2017年06期

【摘要】：目的了解近7年間重慶一醫(yī)院腸道外分離的氣單胞菌對(duì)臨床常用藥物耐藥情況,為臨床合理選擇抗菌藥物提供客觀依據(jù)。方法回顧性分析2010|2016年住院患者腸道外分離的非重復(fù)氣單胞菌株的臨床分布特征并對(duì)14種抗菌藥物的體外藥敏結(jié)果進(jìn)行判讀,采用WHONET5.6軟件進(jìn)行數(shù)據(jù)分析。結(jié)果 2010|2016年共分離腸道外非重復(fù)氣單胞菌230株,以嗜水氣單胞菌最為常見,占83.0%,其次為維氏氣單胞溫和生物變種,占14.8%。主要分離自傷口分泌物,其次為膽汁和尿液。氣單胞菌對(duì)甲氧芐啶-磺胺甲唑耐藥最為嚴(yán)重,耐藥率為46.8%,其次為頭孢曲松(37.0%)和頭孢呋辛(28.8%),對(duì)氨曲南、頭孢吡肟、環(huán)丙沙星的耐藥率在10%以上。對(duì)哌拉西林-他唑巴坦、頭孢西丁、左氧氟沙星、阿米卡星和慶大霉素以及碳青霉烯類抗菌藥物的耐藥率低于10%。其中,對(duì)亞胺培南耐藥率為4.0%,對(duì)美羅培南耐藥率為1.7%。除對(duì)哌拉西林-他唑巴坦、亞胺培南和阿米卡星外,嗜水氣單胞菌對(duì)其他抗菌藥物耐藥率均高于維氏氣單胞溫和生物變種。尚未發(fā)現(xiàn)維氏氣單胞溫和生物變種對(duì)美羅培南耐藥菌株。結(jié)論該院臨床分離氣單胞菌腸道外感染以嗜水氣單胞菌和維氏氣單胞溫和生物變種為主。氣單胞菌科不同菌種對(duì)抗生素的耐藥率有差別。由于氣單胞菌對(duì)甲氧芐啶-磺胺甲唑和第三代頭孢菌素耐藥較為嚴(yán)重,臨床應(yīng)慎重使用。
[Abstract]:Objective to investigate the antimicrobial resistance of Aeromonas isolated from intestinal tract in a hospital of Chongqing in recent seven years and to provide objective evidence for rational selection of antimicrobial agents in clinic. Methods the clinical distribution characteristics of non-repeated Aeromonas isolated from intestinal tract of inpatients in 2010 and 2016 were analyzed retrospectively. The results of drug sensitivity of 14 antimicrobial agents in vitro were analyzed. The data were analyzed by WHONET5.6 software. Results A total of 230 strains of non-repeating Aeromonas were isolated from the intestine in 2010 and 2016. Aeromonas hydrophila was the most common bacteria, accounting for 83.0%, followed by Vickers aeromonas and biological variety 14.8%. Mainly isolated from wound secretion, followed by bile and urine. Aeromonas had the most serious resistance to trimethoprim-sulfamethazolium with a drug resistance rate of 46.8, followed by ceftriaxone 37.0) and cefuroxime 28. 8%. The resistance rates to aztreonam, cefepime and ciprofloxacin were more than 10%. Resistance to piperacillin-tazobactam, cefoxitin, levofloxacin, amikacin, gentamicin and carbapenems was lower than 10. The resistance rate to imipenem was 4.0 and to meropenem was 1.7. With the exception of piperacillin-tazobactam imipenem and amikacin the antimicrobial resistance of Aeromonas hydrophila to other antimicrobial agents was higher than that of Aeromonas Vickers and Amikacin. Vickers Aeromonas and Vickers Gymomonas were not found to be resistant to meropenem. Conclusion Aeromonas hydrophila and Aeromonas Vickers and mild biologic varieties are the main pathogens of extraintestinal infection of Aeromonas aeromonas isolated in our hospital. The resistance rates of different strains of Aeromonas to antibiotics were different. Due to the serious resistance of Aeromonas to trimethoprim-sulfamethazol and third generation cephalosporins, clinical use should be careful.
【作者單位】： 重慶醫(yī)科大學(xué)附屬第一醫(yī)院檢驗(yàn)科;
【基金】：重慶市科學(xué)技術(shù)委員會(huì)基礎(chǔ)與前沿一般項(xiàng)目(cstc2016jcyj A0248)
【分類號(hào)】：R446.5

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