本文選題：金黃色葡萄球菌　切入點(diǎn)：皮膚及軟組織　出處：《中國(guó)抗生素雜志》2017年05期

【摘要】：目的明確嘉興醫(yī)學(xué)院附屬第二醫(yī)院2014年10月—2015年10月皮膚軟組織感染中分離獲得的金黃色葡萄球菌臨床分布特征和耐藥特性,為臨床合理用藥提供理論依據(jù)。方法收集2014年10月—2015年10月期間嘉興醫(yī)學(xué)院附屬第二醫(yī)院皮膚及軟組織感染的患者中分離獲得的金黃色葡萄球菌,采用VITEK2-compact和BD-phoenix 100全自動(dòng)微生物鑒定系統(tǒng)做菌株鑒定和抗菌藥物敏感性試驗(yàn);應(yīng)用WHONET 5.4軟件和SPSS 17.0軟件進(jìn)行耐藥性統(tǒng)計(jì)分析;采用頭孢西丁紙片法確定其中的耐甲氧西林金黃色葡萄球菌(methicillin-resistant Staphylococcus aureus,MRSA)。結(jié)果共分離獲得金黃色葡萄球菌103株,其中來(lái)自皮膚膿腫、癤、癰的37株(35.9%)、化膿性中耳炎6株(5.8%)、甲溝炎6株(5.8%)、皮膚蜂窩組織炎11株(10.7%)、新生兒臍炎7株(6.8%)、皮膚切口感染5株(4.9%)、足趾軟組織感染6株(5.8%)、急性乳腺炎8株(7.8%)、燒傷2株(1.9%)、化膿性皮炎2株(1.9%)、其他包括毛囊炎、新生兒膿皰病等共13株(12.6%);金黃色葡萄球菌主要分離自門診(60.2%,62/103)、兒科病區(qū)(7.8%,8/103)以及燒傷科、骨科等外科病區(qū)(32.0%,33/103);金黃色葡萄球菌中MRSA的檢出率是19.4%,對(duì)青霉素的耐藥率為97.1%,對(duì)四環(huán)素、復(fù)方磺胺甲VA唑、慶大霉素、環(huán)丙沙星的耐藥率分別是18.4%、17.5%、11.7%和10.7%,對(duì)紅霉素和克林霉素的耐藥率在50%以上、對(duì)萬(wàn)古霉素、利奈唑胺敏感率均是100%。結(jié)論嘉興地區(qū)皮膚及軟組織感染中金黃色葡萄球菌主要為社區(qū)獲得性感染。MRSA的攜帶率較高,應(yīng)加強(qiáng)病原菌動(dòng)態(tài)和耐藥變遷的監(jiān)測(cè),尤其是目前敏感性較好的糖肽類抗菌藥物。
[Abstract]:Objective to study the clinical distribution and drug resistance of Staphylococcus aureus isolated from the second affiliated Hospital of Jiaxing Medical College from October 2014 to October 2015.Methods Staphylococcus aureus isolated from patients with skin and soft tissue infections in the second affiliated Hospital of Jiaxing Medical College from October 2014 to October 2015 were collected.VITEK2-compact and BD-phoenix 100 automatic microbial identification system were used to identify strains and antimicrobial susceptibility test, WHONET 5.4 software and SPSS 17.0 software were used for drug resistance statistical analysis.The methicillin-resistant Staphylococcus aureus was determined by cefxitin disk method.Results 103 strains of Staphylococcus aureus were isolated, including skin abscess and furuncle.鐥堢殑37鏍，

本文編號(hào)：1710850