本文選題：急性重度失血性休克　切入點：瑞芬太尼　出處：《中國臨床藥理學雜志》2017年19期

【摘要】：目的研究瑞芬太尼對急性重度失血性休克大鼠的肺保護作用。方法選用50只健康清潔級成年SD大鼠,隨機分為模型組,假手術組和低、中、高3個劑量實驗組,每組10只。模型組建立急性重度失血性休克模型大鼠,其他組在模型組的基礎上靜脈注射負荷劑量瑞芬太尼1μg·kg~(-1),低、中、高3個劑量實驗組分別以0.2,0.6,1.2μg·kg~(-1)·min~(-1)的速率靜脈輸注瑞芬太尼,假手術組游離但不阻斷肺門,模型組與假手術組靜脈輸注與高劑量實驗組等量的0.9%NaCl。病理檢查判斷大鼠肺組織損傷情況,測定各組肺組織干/濕重比值(W/D)、丙二醛(MDA)、超氧化物歧化酶(SOD)、一氧化氮(NO)含量。結(jié)果模型組W/D、MDA、SOD、NO分別為2.97±0.17,(3.45±1.48)nmol·mg~(-1) prot,(11.73±1.78)U·mg~(-1) prot,(0.13±0.03)μmol·mg~(-1) prot,低劑量實驗組分別為2.71±0.12,(2.90±1.03)nmol·mg~(-1) prot,(14.44±1.55)U·mg~(-1) prot,(0.16±0.05)μmol·mg~(-1) prot,與模型組相比,差異均無統(tǒng)計學意義(均P0.05)。中劑量實驗組W/D、MDA、SOD、NO分別為2.33±0.16,(2.29±0.72)nmol·mg~(-1) prot,(15.59±1.80)U·mg~(-1) prot,(0.19±0.05)μmol·mg~(-1) prot,高劑量實驗組分別為2.08±0.07,(1.81±0.64)nmol·mg~(-1) prot,(17.47±1.10)U·mg~(-1) prot,(0.26±0.08)μmol·mg~(-1) prot,與模型組比較,差異均有統(tǒng)計學意義(均P0.05)。結(jié)論瑞芬太尼可通過抑制脂質(zhì)過氧化,減輕肺組織損傷,對急性重度失血性休克大鼠的肺發(fā)揮保護作用。
[Abstract]:Objective to study the lung protective effect of remifentanil on rats with acute severe hemorrhagic shock. Methods Fifty healthy adult SD rats of clean grade were randomly divided into three groups: model group, sham operation group, low, middle and high dose groups. 10 rats in each group were treated with acute severe hemorrhagic shock. The other groups were given remifentanil (1 渭 g kg 路kg ~ (-1)) intravenously on the basis of the model group. The low, middle and high doses of remifentanil were administered at the rate of 0.2U 0.61.2 渭 g / kg / min / min respectively (n = 10), and the other groups received remifentanil intravenously at a rate of 0.2U 0.61.2 渭 g / kg 路min ~ (-1) 路min ~ (-1) 路min ~ (-1). In the sham operation group, the lung hilum was free but not blocked. The model group and the sham operation group received the same amount of 0.9 NaCll as the high dose group. Pathological examination was used to judge the lung tissue injury in rats. The lung tissue dry / wet weight ratio (W / D), malondialdehyde (MDA) MDAD, superoxide dismutase (SOD), nitric oxide (no) were measured in each group. Results in the model group, the content of W- / DDA-SODN was 2.97 鹵0.17 鹵3.45 鹵1.48)nmol mgg-1) prot11.73 鹵1.78 U mg / L) protopril 0.13 鹵0.03) 渭 mol mg-1) prot1) and 2.71 鹵0.122.90 鹵1.03)nmol mg-1) protopril in the low dose group, respectively, compared with the model group, it was 14.44 鹵1.55U mg / L protopril 0.16 鹵0.05U / mg ~ (-1) protopril, 0.13 鹵0.03 渭 mol / mg ~ (-1) proton, respectively, compared with the model group. There was no significant difference between the middle dose group and the high dose group (2.33 鹵0.16 鹵2.29 鹵1.29 鹵0.72)nmol mg / 1). The difference was statistically significant compared with the model group (P 0.05 鹵0.05). Conclusion Remifentanil can inhibit lipid peroxidation by inhibiting lipid peroxidation (P 0.05). Conclusion Remifentanil can inhibit lipid peroxidation by inhibiting lipid peroxidation in the model group (P 0.05 鹵0.07 鹵1.81 鹵1.81 鹵1.81 鹵1.81 鹵1.81 鹵1.81 鹵1.80 渭 mol / mg -1), and the difference is statistically significant compared with the model group (P0.05 鹵0.05). [WT5HZ] [WT5 "HZ] [WT5BZ] [WT5BZ] [WT5BZ] [WT5BZ] [WT5BZ] [WT5BZ] [WT5BZ] [WT5BZ] [WT5BZ] [WT5BZ] [WT5BZ] [WT5BZ] [WT5BZ] [WT5BZ] [WT5BZ] [WT5BZ] [WT5BZ]. To reduce lung injury and protect the lungs of rats with acute severe hemorrhagic shock.
【作者單位】： 海南省人民醫(yī)院急診科;
【基金】：海南省哲學社會科學規(guī)劃課題基金資助項目[HNS(YB)15-33] 海南省衛(wèi)生計生行業(yè)科研基金資助項目(14A200024)
【分類號】：R459.7

【相似文獻】

相關期刊論文 前10條

1 華艷梅;;外科重度失血性休克的護理[J];社區(qū)醫(yī)學雜志;2012年07期

2 范小倩;;普外科重度失血性休克38例急救護理[J];齊魯護理雜志;2012年11期

3 孫玉蘭;;肝破裂重度失血性休克1例護理配合[J];齊魯護理雜志;2008年12期

4 石彥齋;;重度失血性休克患者的手術室護理體會[J];河南外科學雜志;2014年02期

5 王濤;梁燕;邵永強;;重度失血性休克患者的手術室護理體會[J];中國現(xiàn)代藥物應用;2014年14期

6 王國珍;;重度失血性休克的手術室護理體會[J];中國現(xiàn)代藥物應用;2014年15期

7 郝轉(zhuǎn)妮;;重度失血性休克患者的手術室護理體會[J];社區(qū)醫(yī)學雜志;2012年06期

8 陳萍;;重度失血性休克的手術室護理體會[J];當代醫(yī)學;2013年03期

9 高珂;;重度失血性休克患者的手術室護理干預[J];中外醫(yī)療;2014年02期

10 孫美嫻;李偉;龐秀麗;;重度失血性休克48例手術室救治護理體會[J];北方藥學;2013年02期

相關碩士學位論文 前1條

1 黎渝;大鼠急性極重度失血性休克模型的建立[D];廣西醫(yī)科大學;2015年

，

本文編號：1661105