本文選題：急性重度失血性休克　切入點(diǎn)：瑞芬太尼　出處：《中國臨床藥理學(xué)雜志》2017年19期

【摘要】：目的研究瑞芬太尼對(duì)急性重度失血性休克大鼠的肺保護(hù)作用。方法選用50只健康清潔級(jí)成年SD大鼠,隨機(jī)分為模型組,假手術(shù)組和低、中、高3個(gè)劑量實(shí)驗(yàn)組,每組10只。模型組建立急性重度失血性休克模型大鼠,其他組在模型組的基礎(chǔ)上靜脈注射負(fù)荷劑量瑞芬太尼1μg·kg~(-1),低、中、高3個(gè)劑量實(shí)驗(yàn)組分別以0.2,0.6,1.2μg·kg~(-1)·min~(-1)的速率靜脈輸注瑞芬太尼,假手術(shù)組游離但不阻斷肺門,模型組與假手術(shù)組靜脈輸注與高劑量實(shí)驗(yàn)組等量的0.9%NaCl。病理檢查判斷大鼠肺組織損傷情況,測(cè)定各組肺組織干/濕重比值(W/D)、丙二醛(MDA)、超氧化物歧化酶(SOD)、一氧化氮(NO)含量。結(jié)果模型組W/D、MDA、SOD、NO分別為2.97±0.17,(3.45±1.48)nmol·mg~(-1) prot,(11.73±1.78)U·mg~(-1) prot,(0.13±0.03)μmol·mg~(-1) prot,低劑量實(shí)驗(yàn)組分別為2.71±0.12,(2.90±1.03)nmol·mg~(-1) prot,(14.44±1.55)U·mg~(-1) prot,(0.16±0.05)μmol·mg~(-1) prot,與模型組相比,差異均無統(tǒng)計(jì)學(xué)意義(均P0.05)。中劑量實(shí)驗(yàn)組W/D、MDA、SOD、NO分別為2.33±0.16,(2.29±0.72)nmol·mg~(-1) prot,(15.59±1.80)U·mg~(-1) prot,(0.19±0.05)μmol·mg~(-1) prot,高劑量實(shí)驗(yàn)組分別為2.08±0.07,(1.81±0.64)nmol·mg~(-1) prot,(17.47±1.10)U·mg~(-1) prot,(0.26±0.08)μmol·mg~(-1) prot,與模型組比較,差異均有統(tǒng)計(jì)學(xué)意義(均P0.05)。結(jié)論瑞芬太尼可通過抑制脂質(zhì)過氧化,減輕肺組織損傷,對(duì)急性重度失血性休克大鼠的肺發(fā)揮保護(hù)作用。
[Abstract]:Objective to study the lung protective effect of remifentanil on rats with acute severe hemorrhagic shock. Methods Fifty healthy adult SD rats of clean grade were randomly divided into three groups: model group, sham operation group, low, middle and high dose groups. 10 rats in each group were treated with acute severe hemorrhagic shock. The other groups were given remifentanil (1 渭 g kg 路kg ~ (-1)) intravenously on the basis of the model group. The low, middle and high doses of remifentanil were administered at the rate of 0.2U 0.61.2 渭 g / kg / min / min respectively (n = 10), and the other groups received remifentanil intravenously at a rate of 0.2U 0.61.2 渭 g / kg 路min ~ (-1) 路min ~ (-1) 路min ~ (-1). In the sham operation group, the lung hilum was free but not blocked. The model group and the sham operation group received the same amount of 0.9 NaCll as the high dose group. Pathological examination was used to judge the lung tissue injury in rats. The lung tissue dry / wet weight ratio (W / D), malondialdehyde (MDA) MDAD, superoxide dismutase (SOD), nitric oxide (no) were measured in each group. Results in the model group, the content of W- / DDA-SODN was 2.97 鹵0.17 鹵3.45 鹵1.48)nmol mgg-1) prot11.73 鹵1.78 U mg / L) protopril 0.13 鹵0.03) 渭 mol mg-1) prot1) and 2.71 鹵0.122.90 鹵1.03)nmol mg-1) protopril in the low dose group, respectively, compared with the model group, it was 14.44 鹵1.55U mg / L protopril 0.16 鹵0.05U / mg ~ (-1) protopril, 0.13 鹵0.03 渭 mol / mg ~ (-1) proton, respectively, compared with the model group. There was no significant difference between the middle dose group and the high dose group (2.33 鹵0.16 鹵2.29 鹵1.29 鹵0.72)nmol mg / 1). The difference was statistically significant compared with the model group (P 0.05 鹵0.05). Conclusion Remifentanil can inhibit lipid peroxidation by inhibiting lipid peroxidation (P 0.05). Conclusion Remifentanil can inhibit lipid peroxidation by inhibiting lipid peroxidation in the model group (P 0.05 鹵0.07 鹵1.81 鹵1.81 鹵1.81 鹵1.81 鹵1.81 鹵1.81 鹵1.80 渭 mol / mg -1), and the difference is statistically significant compared with the model group (P0.05 鹵0.05). [WT5HZ] [WT5 "HZ] [WT5BZ] [WT5BZ] [WT5BZ] [WT5BZ] [WT5BZ] [WT5BZ] [WT5BZ] [WT5BZ] [WT5BZ] [WT5BZ] [WT5BZ] [WT5BZ] [WT5BZ] [WT5BZ] [WT5BZ] [WT5BZ] [WT5BZ]. To reduce lung injury and protect the lungs of rats with acute severe hemorrhagic shock.
【作者單位】： 海南省人民醫(yī)院急診科;
【基金】：海南省哲學(xué)社會(huì)科學(xué)規(guī)劃課題基金資助項(xiàng)目[HNS(YB)15-33] 海南省衛(wèi)生計(jì)生行業(yè)科研基金資助項(xiàng)目(14A200024)
【分類號(hào)】：R459.7

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