本文選題：可溶性白細(xì)胞分化抗原亞型　切入點(diǎn)：降鈣素原　出處：《中華醫(yī)院感染學(xué)雜志》2017年21期 　論文類型：期刊論文

【摘要】：目的探討血漿可溶性白細(xì)胞分化抗原14亞型(Presepsin)水平對(duì)膿毒癥早期診斷和病情評(píng)估的臨床價(jià)值。方法采用前瞻性研究方法選取2016年9月-12月醫(yī)院重癥監(jiān)護(hù)病房(ICU)住院治療的80例危重病患者,依據(jù)膿毒癥診斷標(biāo)準(zhǔn)分為膿毒癥組40例、膿毒癥休克組40例,選擇同期20例健康體檢者為對(duì)照組,入院時(shí)檢測(cè)所有研究對(duì)象血漿Presepsin、降鈣素原(PCT)、超敏C-反應(yīng)蛋白(hs-CRP)水平,并進(jìn)行急性生理學(xué)與慢性健康狀況評(píng)分系統(tǒng)Ⅱ(APACHEⅡ)評(píng)分和序貫性器官功能衰竭(SOFA)評(píng)分,采用Pearson或Spearman相關(guān)分析法分析Presepsin與PCT、APACHEⅡ評(píng)分、SOFA評(píng)分的相關(guān)性;采用受試者工作特征曲線(ROC)評(píng)估Presepsin、PCT、hs-CRP對(duì)膿毒癥的診斷價(jià)值。結(jié)果膿毒癥休克組血漿Presepsin、PCT及hs-CRP水平均明顯高于膿毒癥組和健康對(duì)照組(P0.01);膿毒癥休克組APACHEⅡ評(píng)分和SOFA評(píng)分高于膿毒癥組(P0.01);Pearson相關(guān)分析結(jié)果顯示,Presepsin與PCT呈顯著正相關(guān)(r=0.517,P0.01);Spearman相關(guān)分析結(jié)果顯示,Presepsin與APACHEⅡ評(píng)分、SOFA評(píng)分呈顯著正相關(guān)(r=0.554,r=0.605,P0.01);ROC曲線分析顯示:Presepsin、PCT、hs-CRP診斷膿毒癥時(shí)的ROC曲線下面積(AUC)分別為(0.917,P0.001;0.691,P0.001;0.625,P0.05)。結(jié)論血漿Presepsin水平可作為膿毒癥患者早期診斷及評(píng)估病情嚴(yán)重程度和預(yù)后的有效指標(biāo)。
[Abstract]:Objective to investigate the clinical value of plasma soluble leukocyte differentiation antigen 14 subtype Presepsin in the early diagnosis and evaluation of sepsis. Methods A prospective study was conducted to select ICU in hospital intensive care unit from September to December 2016. 80 critically ill patients treated in hospital, According to the diagnostic criteria of sepsis, the patients were divided into sepsis group (n = 40), septic shock group (n = 40) and control group (n = 20). The plasma levels of Presepsinin, procalcitonin (PCT), hypersensitive C-reactive protein (hs-CRP) were measured on admission. The acute physiology and chronic health status scoring system 鈪，

本文編號(hào)：1645412