本文選題：降鈣素原　切入點：血流感染　出處：《中華醫(yī)院感染學雜志》2017年08期 　論文類型：期刊論文

【摘要】：目的研究血清降鈣素原檢測在鑒別血流感染病原體類型中的作用,為臨床治療提供參考依據(jù)。方法選取2015年11月1日-2016年10月31日血培養(yǎng)陽性的血流感染患者685例,分為革蘭陽性菌、革蘭陰性菌和真菌組,觀察不同病原體之間降鈣素原檢測的差異性。結(jié)果入組118例血培養(yǎng)陽性的單一血流感染患者共檢出病原菌118株,其中革蘭陽性菌48株占40.68%、革蘭陰性菌64株占54.24%和真菌6株占5.08%,三組降鈣素原檢測均值分別為2.46ng/ml、7.08ng/ml、1.94ng/ml,差異無統(tǒng)計學意義;大腸埃希菌與其他革蘭陰性菌、革蘭陽性菌比較,降鈣素原檢測值均較高,差異有統(tǒng)計學意義(P0.05);經(jīng)ROC曲線分析,PCT的閾值在大腸埃希菌區(qū)別其他革蘭陰性菌、革蘭陽性菌敏感度約為85.00%,但特異度60.00%。結(jié)論血清降鈣素原檢測不能成為鑒別單純血流感染病原體類型的指標,臨床工作中應(yīng)結(jié)合患者的臨床表現(xiàn)等進行綜合分析。
[Abstract]:Objective to study the role of serum procalcitonin detection in differentiating pathogen types of blood stream infection, and to provide reference for clinical treatment. Methods from November 1st 2015 to October 31st 2016, 685 blood stream infection patients with positive blood culture were selected. The difference of procalcitonin detection among different pathogens was observed. Results 118 strains of pathogenic bacteria were detected in 118 patients with single blood stream infection positive by blood culture. Among them, 48 strains of Gram-positive bacteria accounted for 40.68%, 64 strains of Gram-negative bacteria accounted for 54.24% and 6 strains of fungi accounted for 5.08. The mean values of procalcitonin in the three groups were 2.46 ng / ml, 7.08 ng / ml / ml, 1.94 ng / ml, respectively. There was no significant difference between Escherichia coli and other gram-negative bacteria and gram-positive bacteria. The detection value of procalcitonin was higher, the difference was statistically significant (P 0.05), and the threshold value of ROC curve analysis was used to distinguish other gram-negative bacteria from Escherichia coli. The sensitivity of Gram-positive bacteria is about 85.00, but the specificity is 60.00.Conclusion the detection of procalcitonin in serum is not an index to distinguish the pathogen type of pure blood stream infection, and clinical work should be combined with the clinical manifestations of the patients for comprehensive analysis.
【作者單位】： 南京醫(yī)科大學第一附屬醫(yī)院;
【基金】：江蘇高校優(yōu)勢學科建設(shè)工程資助項目(JX10231802) 國家重大科技專項基金(2013ZX10002005-002-005)
【分類號】：R446.5

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