本文選題：量子點(diǎn)　切入點(diǎn)：人造原子　出處：《中華腫瘤防治雜志》2017年06期 　論文類型：期刊論文

【摘要】：量子點(diǎn)(quantum dot,QD),又名"人造原子",是一種用原子人工合成的納米材料,其在紫外光激發(fā)下可發(fā)出不同波長的熒光。QD直徑小、發(fā)出的熒光峰窄、熒光亮度持久,具有取代有機(jī)染料用于腫瘤診治的潛能�？偨Y(jié)近年QD在熒光成像及腫瘤診治方面的研究進(jìn)展。方法應(yīng)用PubMed及中國知網(wǎng)(CNKI)數(shù)據(jù)庫檢索系統(tǒng),以"quantum dots,fluorescence imaging,oncotherapy,tumor therapy,量子點(diǎn),腫瘤治療,腫診斷,熒光成像"為關(guān)鍵詞,檢索2005-01—2016-03的相關(guān)文獻(xiàn)391篇。納入標(biāo)準(zhǔn):(1)可用于生物熒光成像的低毒化QD;(2)靶向識別的功能化QD。根據(jù)納入標(biāo)準(zhǔn)最終分析31篇文獻(xiàn)。結(jié)果低毒化QD在細(xì)胞成像、活體靶向成像、淋巴結(jié)成像、活體腫瘤成像、活體腫瘤細(xì)胞示蹤等熒光成像方面的研究,使正確定位淋巴結(jié)、利用QD深成像能力發(fā)現(xiàn)極小的腫瘤、乃至徹底切除腫瘤組織成為可能。功能化QD在腫瘤早期診斷和治療上發(fā)揮更大作用,QD的藥物靶向和QD介導(dǎo)的光熱治療腫瘤也有很好的臨床應(yīng)用前景。結(jié)論QD在生物熒光成像及腫瘤診療中的潛力巨大,具有進(jìn)一步探索開發(fā)利用于臨床的價值。
[Abstract]:Quantum dot quantum dot QD, also known as "artificial atom," is a kind of nano-material synthesized by atoms. It can emit fluorescence of different wavelengths with small diameter, narrow fluorescence peak and lasting luminescence under the excitation of ultraviolet light. It has the potential to replace organic dyes in the diagnosis and treatment of tumor. This paper summarizes the research progress of QD in the field of fluorescence imaging and tumor diagnosis and treatment in recent years. Methods using PubMed and CNKI database retrieval system, we can use "quantum Dots to fluorescence imaging on tumor therapeutic, quantum dot, tumor therapy". Diagnosis of swelling, fluorescence imaging as the key word, A total of 391 articles of relevant literature from January to March 2016-March 2005 were searched. Inclusion Standard: 1) functional QDs, which can be used in biological fluorescence imaging with low toxicity, were searched. According to the inclusion criteria, 31 articles were analyzed. Results low toxic QD imaging in cells and in vivo targeting imaging, The study of lymph node imaging, in vivo tumor imaging, in vivo tumor cell tracer and other fluorescent imaging, so that the correct location of lymph nodes, using QD deep imaging ability to find minimal tumors, It is possible to remove tumor tissue completely. Functional QD plays a more important role in the early diagnosis and treatment of tumor. Conclusion QD has a good clinical application prospect in the early diagnosis and treatment of tumor and QD-mediated photothermal therapy. The potential for fluorescence imaging and cancer diagnosis and treatment is enormous. It has the value of further exploration and utilization in clinic.
【作者單位】： 安徽醫(yī)科大學(xué)阜陽醫(yī)院急診外科;安徽醫(yī)科大學(xué)第一附屬醫(yī)院中心實(shí)驗(yàn)室;中國科學(xué)技術(shù)大學(xué)物理系納米功能材料實(shí)驗(yàn)室;
【基金】：國家自然科學(xué)基金(51272246;81172082)
【分類號】：R730.44

【相似文獻(xiàn)】

相關(guān)期刊論文 前3條

1 江少凡;涂蓉;尤曉光;;活體熒光成像技術(shù)在MR腫瘤分子影像學(xué)實(shí)驗(yàn)研究中的應(yīng)用[J];功能與分子醫(yī)學(xué)影像學(xué)(電子版);2012年04期

2 劉亭廷;彭程;馬云川;歐陽津;;碳量子點(diǎn)熒光成像法應(yīng)用于聚丙烯酰胺凝膠電泳檢測人血清蛋白質(zhì)的研究[J];化學(xué)學(xué)報;2013年06期

3 ;[J];;年期

相關(guān)碩士學(xué)位論文 前1條

1 鄭瑤;乳腺癌細(xì)胞移植瘤模型的建立及小動物超聲和活體熒光成像中的應(yīng)用比較[D];吉林大學(xué);2015年

，

本文編號：1575436