本文關(guān)鍵詞： 靜息態(tài)功能磁共振成像 阻塞性睡眠呼吸暫停低通氣綜合癥 腦功能網(wǎng)絡(luò) 度中心度　出處：《臨床放射學雜志》2017年02期 　論文類型：期刊論文

【摘要】：目的 利用網(wǎng)絡(luò)中心度(DC)方法探討阻塞性睡眠呼吸暫停低通氣綜合癥(OSAHS)患者在靜息狀態(tài)下腦功能網(wǎng)絡(luò)連接屬性的改變。方法 選擇男性重度OSAHS患者36例及同期招募的年齡、教育程度相匹配的男性正常睡眠者(對照組)40例,采集靜息狀態(tài)下的腦部f MRI數(shù)據(jù),經(jīng)預處理和后處理計算出全腦DC值圖,采用雙樣本t檢驗比較病例組與對照組間DC值分布圖的差異。結(jié)果 與對照組相比,OSAHS組DC值減低的腦區(qū)主要分布在左側(cè)枕中回、左側(cè)額上回、雙側(cè)頂下小葉及后扣帶回皮層;而DC值增高的腦區(qū)主要分布于豆狀核及殼核。結(jié)論OSAHS患者腦功能網(wǎng)絡(luò)連接屬性上存在改變,可表現(xiàn)為多個腦區(qū)度中心性功能連接減低或增高,這可能為理解OSAHS患者認知功能障礙的神經(jīng)病理機制提供一個新的視角。
[Abstract]:Objective to investigate the changes of brain functional network connection properties in patients with obstructive sleep apnea hypopnea syndrome (OSAHS) under resting state by means of network-centered DC.Methods 36 male patients with severe OSAHS and the age of recruitment at the same time were selected. Normal sleep subjects with matched educational level (control group, 40 cases) collected brain f MRI data under resting state, and calculated the whole brain DC value after pretreatment and postprocessing. Results compared with the control group, the distribution of DC value in the OSAHS group was mainly located in the left middle occipital gyrus, the left superior frontal gyrus, the bilateral inferior parietal lobule and the posterior cingulate cortex. The increased DC values were mainly located in the lenticular nucleus and putamen nucleus. Conclusion there are some changes in the properties of cerebral functional network connection in patients with OSAHS, which may be characterized by decreased or increased central functional connections in multiple brain regions. This may provide a new perspective for understanding the neuropathological mechanism of cognitive dysfunction in patients with OSAHS.
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本文編號：1530280