本文關(guān)鍵詞： 驚厥 發(fā)熱性 小腦 磁共振波譜學(xué)　出處：《中國臨床醫(yī)學(xué)影像雜志》2017年01期 　論文類型：期刊論文

【摘要】：目的:應(yīng)用磁共振波譜技術(shù)(MRS)探討單純性高熱驚厥(SFC)患兒的小腦代謝物變化。方法:選取9例確診為SFC的患兒(實(shí)驗(yàn)組)和7例年齡相匹配的健康兒童(對照組),采用化學(xué)位移成像采集小腦的MRS數(shù)據(jù),測量實(shí)驗(yàn)組及對照組的代謝物比值NAA/Cr、NAA/Cr_2、NAA/Cho、Cho/Cr、Cho/Cr_2,采用Mann-Whitney U檢驗(yàn)比較兩組間MRS代謝參數(shù)之間的差異;并統(tǒng)計(jì)兩組間Lac峰出現(xiàn)的例數(shù),應(yīng)用Fisher確切概率法比較有無差異。結(jié)果:實(shí)驗(yàn)組小腦的NAA/Cr低于對照組(0.91±0.12比1.03±0.07,P=0.023),實(shí)驗(yàn)組小腦的NAA/Cr_2、NAA/Cho、Cho/Cr、Cho/Cr_2與對照組間差異無統(tǒng)計(jì)學(xué)意義(均P0.05);實(shí)驗(yàn)組9例患兒中5例小腦區(qū)域發(fā)現(xiàn)明顯的Lac峰,對照組7例兒童小腦均未發(fā)現(xiàn)Lac峰,差別具有統(tǒng)計(jì)學(xué)意義(P=0.034)。結(jié)論:應(yīng)用MRS技術(shù)可敏感的探測SFC患兒腦組織代謝物的變化,有助于從生化角度評價(jià)SFC導(dǎo)致的腦損害。
[Abstract]:Objective: the application of magnetic resonance spectroscopy (MRS) to study the effects of simple febrile convulsion (SFC) cerebellar metabolites changes in children's. Methods: 9 cases diagnosed with SFC patients (experimental group) and 7 age-matched healthy children (control group), MRS data by chemical shift imaging of small brain metabolites. The ratio of experimental group and control group, NAA/Cr, NAA/Cr_2, NAA/Cho, Cho/Cr, Cho/Cr_2, Mann-Whitney using U test the difference between MRS and metabolic parameters were compared between the two groups; and the number of cases of Lac peak statistics between the two groups, using Fisher exact probability method has no difference. Results: the experimental group of cerebellar NAA/Cr was lower than that of control group (0.91 + 0.12 to 1.03 + 0.07, P=0.023), experimental group NAA/Cho, cerebellar NAA/Cr_2, Cho/Cr, there was no significant difference between Cho/Cr_2 and control groups (P0.05); the experimental group of 9 cases in 5 cases of small brain regions were found Lac peak, 7 cases in the control group. Tong Xiaonao did not find Lac peak, the difference was statistically significant (P=0.034). Conclusion: MRS technology can be used to detect the change of metabolites in brain tissue of SFC patients, which helps to evaluate brain damage caused by SFC from biochemical perspective.

【作者單位】： 濱州醫(yī)學(xué)院煙臺附屬醫(yī)院;
【分類號】：R720.597;R445.2

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本文編號：1507119