成纖維細(xì)胞13因子作用于鈉通道1.7選擇性調(diào)控?zé)嵬?/H1>
發(fā)布時(shí)間：2018-01-31 04:54
本文關(guān)鍵詞： 熱痛 傷害性熱刺激 溫度感受器 鈉通道 成纖維細(xì)胞 動(dòng)作電位 感覺(jué)神經(jīng)元 痛反應(yīng) 痛敏 機(jī)械痛 出處：《中國(guó)疼痛醫(yī)學(xué)雜志》2017年04期
論文類型：期刊論文
【摘要】：當(dāng)前關(guān)于傷害性熱痛的認(rèn)識(shí)主要局限于溫度感受器,如表達(dá)在背根神經(jīng)節(jié)(DRG)傷害性感覺(jué)神經(jīng)元上的瞬時(shí)受體電位陽(yáng)離子通道(TRPV1)。但是溫度感受器的缺失僅部分地影響熱痛,表明熱痛的產(chǎn)生和調(diào)控還存在未知機(jī)制。我們發(fā)現(xiàn)在小鼠DRG神經(jīng)元中條件性敲除胞漿型成纖維細(xì)胞13因子(FGF),導(dǎo)致熱痛選擇性缺失;敲除了FGF13的DRG神經(jīng)元,傷害性熱刺激不能誘發(fā)動(dòng)作電位的持續(xù)發(fā)放;FGF13與鈉通道(Nav)1.7作用可以促進(jìn)熱痛的傳導(dǎo),增強(qiáng)傷害性熱刺激誘發(fā)的Nav1.7電流并維持Nav1.7上膜過(guò)程,進(jìn)而維持動(dòng)作電位的持續(xù)發(fā)放。打破FGF13和Nav1.7相互作用抑制了熱刺激誘發(fā)的動(dòng)作電位和痛反射行為。因此,不同于溫度感受器,FGF13和Nav1.7的相互作用對(duì)于維持熱痛信號(hào)的產(chǎn)生和傳遞是至關(guān)重要的。
[Abstract]:Current knowledge of nociceptive heat pain is mainly confined to temperature receptors. For example, the transient receptor potential cationic channel (TRPV1) expressed in the nociceptive sensory neurons of DRG was only partially affected by the absence of thermosensitive receptors. We found that conditioned knockout of cytoplasmic fibroblast 13 factor 13 in mouse DRG neurons resulted in the absence of heat pain selectivity. If the DRG neurons of FGF13 were knocked out, nociceptive thermal stimulation could not induce the continuous release of action potential. The interaction of FGF13 with sodium channel Navine 1.7 can promote the conduction of thermal pain, enhance the Nav1.7 current induced by nociceptive heat stimulation and maintain the process of Nav1.7 supermembrane. Thus, breaking the interaction between FGF13 and Nav1.7 inhibits the action potential and pain reflex induced by thermal stimulation. Therefore, it is different from the temperature receptor. The interaction between FGF13 and Nav1.7 is essential to maintain the generation and transmission of thermal pain signals.
【分類號(hào)】：R402
【正文快照】： 研究背景 FGF分為外泌型和胞漿型,外泌型FGF在神經(jīng)發(fā)育過(guò)程中發(fā)揮著重要作用,但對(duì)胞漿型FGF功能的研究卻很少。FGF13是表達(dá)在神經(jīng)系統(tǒng)中的胞漿型因子,在發(fā)育過(guò)程中的腦皮質(zhì)神經(jīng)元上有瞬時(shí)表達(dá);在從發(fā)育早期到成年DRG中,FGF13一直高水平表達(dá),其主要有兩個(gè)剪接體亞型,FGF13A具 【相似文獻(xiàn)】
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1 宋麗萍;Andrew C.N.Chen;;經(jīng)皮神經(jīng)電刺激對(duì)實(shí)驗(yàn)性冷痛和熱痛的對(duì)側(cè)調(diào)制[J];山西醫(yī)科大學(xué)學(xué)報(bào);2009年04期
2 陳桂英,張?jiān)茣?李淑娥,臺(tái)立穩(wěn);以末梢神經(jīng)炎為首發(fā)癥狀的紅熱痛1例[J];臨床薈萃;2004年06期
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4 杜一華;熱痛寧中藥灌腸治療胰腺炎腹脹的護(hù)理體會(huì)[J];云南中醫(yī)中藥雜志;2001年03期
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1 靳梅;謝炳s，
本文編號(hào)：1478254
本文鏈接：http://sikaile.net/linchuangyixuelunwen/1478254.html
本文關(guān)鍵詞： 熱痛 傷害性熱刺激 溫度感受器 鈉通道 成纖維細(xì)胞 動(dòng)作電位 感覺(jué)神經(jīng)元 痛反應(yīng) 痛敏 機(jī)械痛 出處：《中國(guó)疼痛醫(yī)學(xué)雜志》2017年04期 論文類型：期刊論文
【摘要】：當(dāng)前關(guān)于傷害性熱痛的認(rèn)識(shí)主要局限于溫度感受器,如表達(dá)在背根神經(jīng)節(jié)(DRG)傷害性感覺(jué)神經(jīng)元上的瞬時(shí)受體電位陽(yáng)離子通道(TRPV1)。但是溫度感受器的缺失僅部分地影響熱痛,表明熱痛的產(chǎn)生和調(diào)控還存在未知機(jī)制。我們發(fā)現(xiàn)在小鼠DRG神經(jīng)元中條件性敲除胞漿型成纖維細(xì)胞13因子(FGF),導(dǎo)致熱痛選擇性缺失;敲除了FGF13的DRG神經(jīng)元,傷害性熱刺激不能誘發(fā)動(dòng)作電位的持續(xù)發(fā)放;FGF13與鈉通道(Nav)1.7作用可以促進(jìn)熱痛的傳導(dǎo),增強(qiáng)傷害性熱刺激誘發(fā)的Nav1.7電流并維持Nav1.7上膜過(guò)程,進(jìn)而維持動(dòng)作電位的持續(xù)發(fā)放。打破FGF13和Nav1.7相互作用抑制了熱刺激誘發(fā)的動(dòng)作電位和痛反射行為。因此,不同于溫度感受器,FGF13和Nav1.7的相互作用對(duì)于維持熱痛信號(hào)的產(chǎn)生和傳遞是至關(guān)重要的。
[Abstract]:Current knowledge of nociceptive heat pain is mainly confined to temperature receptors. For example, the transient receptor potential cationic channel (TRPV1) expressed in the nociceptive sensory neurons of DRG was only partially affected by the absence of thermosensitive receptors. We found that conditioned knockout of cytoplasmic fibroblast 13 factor 13 in mouse DRG neurons resulted in the absence of heat pain selectivity. If the DRG neurons of FGF13 were knocked out, nociceptive thermal stimulation could not induce the continuous release of action potential. The interaction of FGF13 with sodium channel Navine 1.7 can promote the conduction of thermal pain, enhance the Nav1.7 current induced by nociceptive heat stimulation and maintain the process of Nav1.7 supermembrane. Thus, breaking the interaction between FGF13 and Nav1.7 inhibits the action potential and pain reflex induced by thermal stimulation. Therefore, it is different from the temperature receptor. The interaction between FGF13 and Nav1.7 is essential to maintain the generation and transmission of thermal pain signals.
【分類號(hào)】：R402
【正文快照】： 研究背景 FGF分為外泌型和胞漿型,外泌型FGF在神經(jīng)發(fā)育過(guò)程中發(fā)揮著重要作用,但對(duì)胞漿型FGF功能的研究卻很少。FGF13是表達(dá)在神經(jīng)系統(tǒng)中的胞漿型因子,在發(fā)育過(guò)程中的腦皮質(zhì)神經(jīng)元上有瞬時(shí)表達(dá);在從發(fā)育早期到成年DRG中,FGF13一直高水平表達(dá),其主要有兩個(gè)剪接體亞型,FGF13A具
【相似文獻(xiàn)】
相關(guān)期刊論文 前5條
1 宋麗萍;Andrew C.N.Chen;;經(jīng)皮神經(jīng)電刺激對(duì)實(shí)驗(yàn)性冷痛和熱痛的對(duì)側(cè)調(diào)制[J];山西醫(yī)科大學(xué)學(xué)報(bào);2009年04期
2 陳桂英,張?jiān)茣?李淑娥,臺(tái)立穩(wěn);以末梢神經(jīng)炎為首發(fā)癥狀的紅熱痛1例[J];臨床薈萃;2004年06期
3 陳桂英,張?jiān)茣?李錦,高愛鮮,臺(tái)立穩(wěn);表現(xiàn)為高血壓的原發(fā)性紅熱痛2例[J];疑難病雜志;2004年02期
4 杜一華;熱痛寧中藥灌腸治療胰腺炎腹脹的護(hù)理體會(huì)[J];云南中醫(yī)中藥雜志;2001年03期
5 ;[J];;年期
相關(guān)會(huì)議論文 前1條
1 靳梅;謝炳s，
本文編號(hào)：1478254
本文鏈接：http://sikaile.net/linchuangyixuelunwen/1478254.html
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