本文關(guān)鍵詞： 重癥監(jiān)護(hù)病房 膿毒癥 血清降鈣素原 白細(xì)胞介素- C反應(yīng)蛋白　出處：《國際檢驗(yàn)醫(yī)學(xué)雜志》2017年01期 　論文類型：期刊論文

【摘要】：目的探討聯(lián)合檢測血清降鈣素原(PCT)、白細(xì)胞介素-6(IL-6)和C反應(yīng)蛋白(CRP)在重癥監(jiān)護(hù)病房(ICU)膿毒癥患者早期診斷中的應(yīng)用。方法選擇ICU病區(qū)明確診斷的早期膿毒癥患者89例(膿毒癥組),發(fā)熱高峰期且未使用抗菌藥物時(shí),采血送血培養(yǎng)并檢測PCT、IL-6、CRP水平,同時(shí)選擇同時(shí)期來本院健康體檢者132例(健康對照組),采血檢測PCT、IL-6、CRP水平。PCT、IL-6的檢測為電化學(xué)發(fā)光法,CRP的檢測為免疫透射比濁法。結(jié)果 ICU膿毒癥患者PCT、IL-6、CRP檢測值明顯高于健康對照組,且差異具有統(tǒng)計(jì)學(xué)意義(P0.01);聯(lián)合檢測的敏感性和特異性明顯高于單獨(dú)檢測,PCT+IL-6、PCT+CRP、PCT+IL-6+CRP 3種聯(lián)合檢測組合的敏感性分別為91.3%、90.5%和91.9%,特異性分別為89.5%、88.3%和89.4%,準(zhǔn)確度分別為85.5%、85.3%和85.6%。結(jié)論聯(lián)合檢測PCT+IL-6+CRP、PCT+IL-6或PCT+CRP,有助于臨床識別早期膿毒癥。
[Abstract]:Objective to investigate the combined detection of serum procalcitonin (PCT). Interleukin-6 (IL-6) and C-reactive protein (CRP) in intensive care unit (ICU). Methods 89 patients with early sepsis (sepsis group) with definite diagnosis in ICU area were selected. During the peak period of fever and no use of antimicrobial agents, blood was collected for blood culture and the level of IL-6 CRP was measured. 132 cases of healthy examination in the same period were selected (healthy control group). The serum levels of IL-6 and IL-6 were detected by electrochemiluminescence (ECL) and immunoturbidimetry. Results PCT was detected in patients with ICU sepsis. The level of IL-6 CRP was significantly higher than that of the healthy control group, and the difference was statistically significant (P 0.01). The sensitivity and specificity of combined detection were significantly higher than that of single detection of PCT IL-6 CRP. The sensitivity of PCT IL-6 CRP was 90.5% and 91.9%, and the specificity was 89.5% and 89.4%, respectively. The accuracy was 85.3% and 85.6%, respectively. Conclusion PCT IL-6 CRPP-PCT IL-6 or PCT CRP can be detected in combination. It is helpful for clinical identification of early sepsis.
【作者單位】： 廣東省佛山市三水區(qū)人民醫(yī)院;
【分類號】：R459.7
【正文快照】： 膿毒癥是致病微生物入侵患者機(jī)體,微生物或其產(chǎn)生的毒素通過血液循環(huán)系統(tǒng)播散而造成的人體對感染的全身性炎性反應(yīng),是重癥監(jiān)護(hù)病房(ICU)重度創(chuàng)傷、全身性感染、大型手術(shù)后、介入治療感染等重癥患者的嚴(yán)重并發(fā)癥之一,病死率高。ICU膿毒癥患者病情進(jìn)展迅速,臨床癥狀復(fù)雜,早期診

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