發(fā)布時間：2018-01-26 12:08

  本文關鍵詞： 非腫塊型乳腺癌 超聲彈性成像 免疫組化　出處：《青島大學》2017年碩士論文　論文類型：學位論文

【摘要】：目的:分析非腫塊型乳腺癌的常規(guī)超聲及其彈性成像特點,結合免疫組化結果,研究其相關性,為非腫塊型乳腺癌的早診斷、治療及其預后提供新的依據(jù)。方法:收集30例經過病理證實的乳腺癌患者,超聲表現(xiàn)為非腫塊型,記錄其常規(guī)超聲表現(xiàn)(位置、大小、邊界、血流、阻力指數(shù)、回聲等);記錄其彈性成像應變率比值并進行彈性評分;將病灶分級,結合其彈性成像特點與其免疫組化結果:雌激素受體(estrogen receptor ER)、孕激素受體(progesterone receptor PR)、腫瘤抑制基因(tumor suppressor gene P53)、人類表皮生長因子相關基因2(human epidermal growth factor receptor HER-2),進行相關性分析。結果:彈性評分與ER相關(P0.05);彈性評分與PR相關(P0.05);彈性評分與Her-2無相關性(P0.05);彈性評分與P53相關(P0.05)。彈性評分4-5級組的ER、PR陽性表達率高于、P53陽性表達率低于1-3級組。應變率比值(Strain Ratio SR)與ER相關(P0.05);SR與PR相關(P0.05);SR與Her-2相關(P0.05);SR與P53相關(P0.05)。SR≥3.0組的PR陽性表達率低于、ER、Her-2、P53陽性表達率高于SR3組。結論:1.非腫塊型乳腺癌彈性成像特點與其免疫組化因子ER、PR、P53表達具有相關性,為非腫塊型乳腺癌治療及其預后提供幫助。2.彈性評分4-5級組的非腫塊型乳腺癌具有較高的ER、PR陽性表達率、較低的P53陽性表達率,預示其更適合內分泌治療,預后較好。3.SR≥3.0的非腫塊型乳腺癌具有較低的PR陽性表達率,較高的ER、Her-2、P53陽性表達率,預示其不適合內分泌治療,預后不好。
[Abstract]:Objective: to analyze the characteristics of conventional ultrasound and elastic imaging of non-mass breast cancer, and to study its correlation with immunohistochemical results, so as to make an early diagnosis of non-mass breast cancer. Methods: 30 cases of breast cancer confirmed by pathology were collected and their ultrasonographic manifestations were non-mass type. The conventional ultrasonographic findings (location, size, boundary, blood flow) were recorded. Resistance index, echo etc.; The strain rate ratio of elastic imaging was recorded and the elastic score was evaluated. The lesions were classified, combined with their elastic imaging features and immunohistochemical results: estrogen receptor estrogen receptor ERS. Progesterone receptor prostaglandin, tumor suppressor suppressor gene p53). Human epidermal growth factor receptor HER-2). Results: elasticity score was correlated with ER (P 0.05); Elastic score was correlated with PR (P 0.05); There was no correlation between elasticity score and Her-2. The positive expression rate of ERP PR was higher in the group of elastic score 4-5 grades than that in the group of P 53. The positive expression rate of ERP PR was higher in the group with elastic score 4-5. The positive expression rate of p53 was lower than that of grade 1-3. Strain rate ratio (strain Ratio SRS) was correlated with ER (P 0.05). SR and PR were related to P0.05; The correlation between SR and Her-2 was P0.05; The positive expression rate of PR in SR and p53 related group was lower than that in ERH Her-2 group. The positive rate of PR expression in SR 鈮，

本文編號：1465568