本文關(guān)鍵詞：ICU醫(yī)院感染患者病原菌分布特點(diǎn)及血清PCT變化與預(yù)后臨床價(jià)值分析　出處：《中華醫(yī)院感染學(xué)雜志》2017年13期 　論文類型：期刊論文

  更多相關(guān)文章： ICU感染 病原菌 降鈣素原 預(yù)后

【摘要】：目的探討ICU醫(yī)院感染患者病原菌分布特點(diǎn)及血清降鈣素原(PCT)變化與預(yù)后臨床價(jià)值。方法選取醫(yī)院2015年1月-2016年12月ICU感染患者98例作為觀察組,另選醫(yī)院同期健康體檢者73例作為對照組,采集患者血液/痰液標(biāo)本分離病原菌,進(jìn)行細(xì)菌鑒定,其中革蘭陽性菌藥敏試驗(yàn)采用GN201法,革蘭陰性菌藥敏試驗(yàn)采用GP法,以紙片擴(kuò)散法進(jìn)行藥敏試驗(yàn);同時(shí)采集入組研究對象外周靜脈血,分離血清,采用半定量固相免疫測定法測定血清PCT含量,比較兩組血清PCT水平變化及死亡組和存活組血清PCT水平變化。結(jié)果 ICU感染患者98例檢出病原菌107株,其中革蘭陰性菌61株占57.01%,革蘭陽性菌38株占35.51%,真菌8株占7.48%;主要革蘭陰性菌對頭孢曲松和頭孢噻肟耐藥率較高;主要革蘭陽性菌對青霉素和紅霉素耐藥率較高;觀察組血清PCT水平高于對照組(P0.05);死亡患者血清PCT水平高于存活患者(P0.05)。結(jié)論 ICU醫(yī)院感染患者病原菌分布以革蘭陰性菌為主,其血清PCT水平明顯上升,且其水平對患者預(yù)后具有積極作用,故而具有重要臨床研究價(jià)值。
[Abstract]:Objective to investigate the distribution of pathogenic bacteria and serum procalcitonin in patients with ICU nosocomial infection. Methods 98 patients with ICU infection from January 2015 to December 2016 were selected as observation group. Another 73 healthy people were selected as control group. Blood / sputum samples of patients were collected to isolate pathogenic bacteria and bacteria were identified. Gram-positive bacteria susceptibility test was performed by GN201 method. Gram-negative bacteria susceptibility test was performed by GP method and disk diffusion test. At the same time, the peripheral venous blood was collected and the serum was isolated. The serum PCT content was determined by semi-quantitative solid-phase immunoassay. The changes of serum PCT level and serum PCT level in death group and survival group were compared between the two groups. Results 107 strains of pathogenic bacteria were detected in 98 patients with ICU infection. Among them, 61 strains of Gram-negative bacteria accounted for 57.01%, 38 strains of Gram-positive bacteria accounted for 35.51%, and 8 strains of fungi accounted for 7.48%. The resistance rate of main Gram-negative bacteria to ceftriaxone and cefotaxime was higher. The resistant rate of main gram-positive bacteria to penicillin and erythromycin was higher. The serum PCT level in the observation group was higher than that in the control group (P 0.05). The serum PCT level of the dead patients was higher than that of the surviving patients (P 0.05). Conclusion the distribution of pathogenic bacteria in patients with ICU nosocomial infection is mainly Gram-negative bacteria, and the serum PCT level is obviously increased. And its level has a positive effect on the prognosis of patients, so it has important clinical research value.
【作者單位】： 廣東省人民醫(yī)院(廣東省醫(yī)學(xué)科學(xué)院)急危重癥醫(yī)學(xué)部;
【基金】：廣東省醫(yī)學(xué)科研技術(shù)基金資助項(xiàng)目(A20160800)
【分類號】：R446.5
【正文快照】： 重癥監(jiān)護(hù)室(ICU)收治的患者具有病情危重特點(diǎn),且伴各種循環(huán)衰竭、呼吸衰竭,大部分需各種抗菌藥物治療、各種侵入性操作、治療時(shí)間長、醫(yī)院感染率高于其他科室[1-2]。醫(yī)院感染主要是指住院患者于醫(yī)院內(nèi)獲得的感染,不包括入院前存在的感染或者入院時(shí)已存在的感染[3]。ICU醫(yī)院感

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