本文關(guān)鍵詞：原發(fā)性膽汁性肝硬化患者IgG型自身抗體檢測的臨床價(jià)值　出處：《檢驗(yàn)醫(yī)學(xué)與臨床》2017年02期 　論文類型：期刊論文

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【摘要】：目的分析原發(fā)性膽汁性肝硬化(PBC)患者的自身免疫性肝病抗體譜及抗核抗體熒光核型,探討其在PBC診斷及臨床應(yīng)用中的意義。方法選擇已確診的PBC患者67例及病例對(duì)照組70例,檢測自身免疫性肝病抗體譜,間接免疫熒光法檢測抗核抗體,應(yīng)用SPSS17.0統(tǒng)計(jì)軟件進(jìn)行分析處理。結(jié)果 PBC患者組陽性檢出率以AMA-M2抗體、Sp100抗體及gp210抗體為主,抗核抗體熒光核型以核點(diǎn)型和胞漿顆粒型為主。AMA-M2抗體、Sp100抗體和gp210抗體在PBC患者的陽性率顯著高于對(duì)照組(χ2=37.228,5.492和16.292,P0.01);而LKM1抗體、LC1抗體、SLA抗體陽性率與對(duì)照組比較,差異無統(tǒng)計(jì)學(xué)意義(P0.05)。結(jié)論自身免疫性肝病抗體譜,特別是血清AMA-M2陽性是診斷PBC的重要指標(biāo)之一,另外Sp100抗體、gp210抗體也是PBC診斷的特征性抗體,其對(duì)AMA-M2陰性PBC的診斷具有重要作用。
[Abstract]:Objective to analyze the autoimmune liver disease antibody spectrum and the fluorescence karyotype of antinuclear antibody in patients with primary biliary cirrhosis (PBC). Methods 67 cases of PBC and 70 cases of control group were selected to detect the antibody spectrum of autoimmune liver disease. Indirect immunofluorescence assay was used to detect the antinuclear antibody and SPSS17.0 software was used to analyze it. Results the positive rate of PBC patients was AMA-M2 antibody. The Sp100 antibody and gp210 antibody were dominant, and the fluorescent karyotype of antinuclear antibody was nuclear point type and cytoplasmic granule type. AMA-M2 antibody was the main type. The positive rates of Sp100 antibody and gp210 antibody in PBC patients were significantly higher than those in the control group (蠂 ~ 2 + 37.22 28 ~ 5.492 and 16.292% P _ (0.01)). However, there was no significant difference in the positive rate of LKM1 antibody against LC1 antibody and SLA antibody between the control group and the control group. Conclusion the antibody spectrum of autoimmune liver disease is not significantly different from that of the control group (P < 0.05). In particular, the positive serum AMA-M2 is one of the important indexes in the diagnosis of PBC. In addition, the Sp100 antibody, gp210, is also the characteristic antibody in the diagnosis of PBC. It plays an important role in the diagnosis of AMA-M2 negative PBC.
【作者單位】： 昆明醫(yī)科大學(xué)附屬延安醫(yī)院醫(yī)學(xué)檢驗(yàn)科;昆明醫(yī)科大學(xué)附屬延安醫(yī)院消化科;
【基金】：云南省科技廳-昆明醫(yī)科大學(xué)聯(lián)合專項(xiàng)項(xiàng)目(2015FB086) 昆明醫(yī)科大學(xué)研究生創(chuàng)新基金資助項(xiàng)目(2016S43)
【分類號(hào)】：R575.22;R446.6
【正文快照】： 原發(fā)性膽汁性肝硬化(PBC)是一種病因和發(fā)病機(jī)制尚不完全清楚的慢性進(jìn)行性膽汁淤積性肝臟病變,病理表現(xiàn)為肝內(nèi)膽管非化膿性炎性伴有小葉間膽管破壞、門靜脈周圍炎和肝實(shí)質(zhì)碎屑樣壞死,最終進(jìn)展為肝硬化[1]。該病多見于中年女性,患者血清中常常出現(xiàn)抗線粒體抗體,此自身抗體是PBC

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