本文關(guān)鍵詞：三維面積應變早期檢測Duchenne型肌營養(yǎng)不良兒童亞臨床左室收縮功能損傷　出處：《中國超聲醫(yī)學雜志》2017年06期 　論文類型：期刊論文

  更多相關(guān)文章： 三維超聲斑點追蹤 面積應變 心室功能 Duchenne型肌營養(yǎng)不良

【摘要】：目的探討三維斑點追蹤超聲心動圖成像(3D-STE)整體面積應變(GAS)早期檢測Duchenne型肌營養(yǎng)不良(DMD)患兒亞臨床左室收縮功能損傷的可行性及臨床意義。方法選取51例DMD患兒及31例正常對照兒童。應用二維及三維超聲心動圖檢查獲得左心室二維及三維左心室射血分數(shù)(LVEF)以及左室GAS。比較兩組左心室收縮功能指標的差異。結(jié)果 DMD組與正常對照組的二維超聲心動圖指標差異無統(tǒng)計學意義(均P0.05)。與正常對照組相比,DMD組三維容積指標及左室射血分數(shù)無明顯變化(均P0.05),而GAS顯著減低(-26.5±5.8vs-30.7±4.05,P0.01),差異有統(tǒng)計學意義。結(jié)論三維面積應變可定量評估DMD患兒左心室收縮功能,早期檢測出DMD患兒的左室收縮功能損傷,為臨床對DMD患兒心臟功能損傷的早期干預和判斷預后提供有價值的參考。
[Abstract]:Objective to investigate the early detection of Duchenne type muscular dystrophy by 3D-STE (3D-STE) global area strain (GASS) in three dimensional speckle tracing echocardiography (3D-STE). The feasibility and clinical significance of subclinical left ventricular systolic function injury in children. Methods 51 children with DMD and 31 normal children were selected. Two-dimensional and three-dimensional echocardiography were used to obtain left ventricular two-dimensional and three-dimensional echocardiography. Left ventricular ejection fraction (LVEF). Results there was no significant difference in left ventricular systolic function between DMD group and normal control group (P 0.05). Compared with the normal control group. In DMD group, there was no significant change in 3D volume index and left ventricular ejection fraction (P0.05, P 0.01), but GAS decreased significantly (-26.5 鹵5.8 vs-30.7 鹵4.05). Conclusion Three-dimensional area strain can be used to quantitatively evaluate left ventricular systolic function in children with DMD and early detection of left ventricular systolic function injury in children with DMD. To provide a valuable reference for early intervention and prognosis of heart function injury in children with DMD.
【作者單位】： 深圳市兒童醫(yī)院超聲科;深圳市兒童醫(yī)院神經(jīng)肌肉病研究室;
【基金】：深圳市衛(wèi)生計生系統(tǒng)科研項目(No.201402051) 深圳市科技研發(fā)資金基礎(chǔ)研究項目(No.JCYJ20140416141331487)
【分類號】：R445.1;R746.2
【正文快照】： 杜氏型肌營養(yǎng)不良(duchenne　muscular　dystro-phy,DMD)為臨床常見兒童致死性肌萎縮疾病,存活男嬰發(fā)病率約為1/3　500[1]。本病是X連鎖隱性遺傳性肌變性疾病,由于染色體上抗肌萎縮蛋白基因缺陷所致。心臟病變?nèi)找娉蔀榛颊咚劳龅氖滓�。超聲心動圖是臨床最常用評估DMD心臟

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