本文關(guān)鍵詞：抑郁性失眠多導(dǎo)睡眠圖研究　出處：《浙江大學(xué)》2017年碩士論文　論文類型：學(xué)位論文

  更多相關(guān)文章： 抑郁性失眠 原發(fā)性失眠 多導(dǎo)睡眠圖

【摘要】：背景:抑郁性失眠和原發(fā)性失眠臨床表現(xiàn)相似,兩者容易混淆,依靠癥狀學(xué)作出的診斷容易發(fā)生誤診。抑郁癥患者多導(dǎo)睡眠圖(Polysomnography,PSG)異常改變被認(rèn)為是一種生物標(biāo)記。PSG在抑郁性失眠和原發(fā)性失眠的鑒別診斷中是否有價(jià)值仍不清楚。目的:研究抑郁性失眠多導(dǎo)睡眠圖的特點(diǎn),為抑郁癥診斷提供生物學(xué)指標(biāo)。方法:本研究納入符合國(guó)際疾病分類(第10版)(International Classification of Diseases 10,ICD-10)抑郁障礙診斷標(biāo)準(zhǔn)的86名患者,選擇同時(shí)符合失眠(匹茲堡睡眠量表評(píng)分6分,失眠病程1個(gè)月,每周至少3天存在失眠癥狀)診斷標(biāo)準(zhǔn)的患者52例作為抑郁性失眠組;納入符合原發(fā)性失眠患者38例為原發(fā)性失眠組。在消除藥物對(duì)PSG的影響后,記錄兩組患者首夜PSG臨床常用指標(biāo),采用卡方檢驗(yàn)和t檢驗(yàn)分析抑郁癥性失眠與原發(fā)性失眠患者的PSG的差異。結(jié)果:與原發(fā)性失眠相比,兩組在(1)睡眠進(jìn)程:睡眠潛伏期[(35.93±10.69)分鐘vs(64.74±19.65)分鐘)差異有顯著性(t=8.93,t檢驗(yàn),P0.01);總睡眠時(shí)間、睡眠效率、N2期睡眠潛伏期、入睡后醒覺(jué)時(shí)間、5min醒覺(jué)次數(shù)、微覺(jué)醒次數(shù),差異無(wú)顯著性(P0.05)。(2)睡眠結(jié)構(gòu):N1次數(shù)分別為(9.40±2.62)和(10.63±3.07),有差異(t=2.04,t檢驗(yàn),P=0.04),而兩組的覺(jué)睡比、N1睡眠比、N2睡眠比、N2次數(shù)、N3睡眠比、N3次數(shù)差異均無(wú)顯著性(P0.05)。(3)快動(dòng)眼睡眠潛伏期分別為(83.23±18.64)分鐘和(188.71±49.44)分鐘,差異有顯著性(t=14.01,t檢驗(yàn),P0.01);快動(dòng)眼睡眠時(shí)間比分別為(9.68±2.31)vs(7.43±2.84),差異有顯著性(t=4.14,t檢驗(yàn),P0.01);但兩組快動(dòng)眼睡眠次數(shù)差異無(wú)顯著性(P0.05)。結(jié)論:抑郁性失眠患者與原發(fā)性失眠患者PSG指標(biāo)有差異,如睡眠潛伏期和快動(dòng)眼睡眠潛伏期以及快動(dòng)眼睡眠時(shí)間比差異顯著,PSG的這些特點(diǎn)可以作為兩種失眠鑒別的輔助手段。
[Abstract]:Background: depressive insomnia and similar primary insomnia clinical manifestations, both easy to confuse, rely on the diagnosis of symptoms made to misdiagnosis. Polysomnography in patients with depression (Figure Polysomnography, PSG) abnormality is considered whether a biomarker.PSG value in depressive insomnia and the differential diagnosis of primary insomnia still unclear. Objective: To study the characteristics of depressive insomnia polysomnography, provide biological indices for diagnosis of depression. Methods: This study included in the international classification of diseases (Tenth Edition) (International Classification of Diseases 10, ICD-10) in 86 patients with a diagnosis of depression disorder standard, at the same time with the choice of Pittsburgh (the amount of sleep insomnia table 6 scores, sleep duration of 1 months, at least 3 days a week there are 52 cases of insomnia symptoms) as the diagnostic criteria of depressive insomnia group patients; patients with primary insomnia in 38 cases 涓哄師鍙戞，

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