斑點追蹤技術(shù)定量評價尿毒癥心肌病左室肥厚及形變對心功能的影響
本文關(guān)鍵詞:斑點追蹤技術(shù)定量評價尿毒癥心肌病左室肥厚及形變對心功能的影響 出處:《中南大學(xué)學(xué)報(醫(yī)學(xué)版)》2017年04期 論文類型:期刊論文
更多相關(guān)文章: 尿毒癥心肌病 心功能 左室肥厚 形變 應(yīng)變 應(yīng)變率 收縮期扭轉(zhuǎn)角度 組織運動瓣環(huán)位移
【摘要】:目的:應(yīng)用二維斑點追蹤技術(shù)(two dimensional speckle tracking imaging,2D-STI)檢測尿毒癥心肌病(uremic cardiomyopathy,UCM)患者心肌生物力學(xué)參數(shù),評價左室肥厚及左室形變對心功能的影響。方法:隨機將67例UCM患者分為臨床心功能正常組(A亞組,32例)及心功能異常組(B亞組,35例),另選30例作為正常對照組。比較受檢者臨床心功能分級積分NYHA-P、左室射血分?jǐn)?shù)(left ventricular ejection fraction,LVEF)、左室重量指數(shù)(left ventricular mass index,LVMI)、左室球形指數(shù)(left ventricular spherical index,LVSI)以及心肌生物力學(xué)參數(shù)即左室平均徑向應(yīng)變(mean radial strain,MRS)、平均徑向應(yīng)變率(mean radial strain rate,MRSR)、平均縱向應(yīng)變(mean longitudinal strain,MLS)、組織運動瓣環(huán)位移(tissue motion annular displacement,TMAD)、左室心肌收縮期扭轉(zhuǎn)角度(systolic twist angle,STA)。結(jié)果:UCM組LVMI增大,而STA,MLS,MRS,MRSR,TMAD,LVSI減低(P0.05)。UCM組中B亞組與A亞組比較:LVMI差異無統(tǒng)計學(xué)意義(P0.05),MLS,MRS,MRSR,STA,TMAD,LVSI減低(P0.05)。正常對照組和UCM組MLS絕對值與LVEF均呈正相關(guān);UCM患者MLS絕對值與LVSI呈正相關(guān),與LVMI呈負相關(guān)。以MLS 14.10%為截斷點判定患者NYHA-P4分靈敏度為90.5%,特異度為71%,Yuedden指數(shù)最高0.585。UCM患者心肌收縮期STA較對照組減低(P0.05)。結(jié)論:用2D-STI技術(shù)檢測心肌生物力學(xué)參數(shù)來評價UCM患者左室局部功能具有獨特的優(yōu)越性,左室肥厚與心室形變無直接相關(guān),臨床心功能分級與左室肥厚及心室形變相關(guān),與局部心功能參數(shù)相關(guān)性更明顯,局部心肌力學(xué)參數(shù)改變存在于心功能分級尚好及心室重構(gòu)程度較輕的患者,局部心肌力學(xué)參數(shù)下降預(yù)示心功能向異;l(fā)展。
[Abstract]:Objective: to apply two dimensional speckle tracking imaging. 2D-STI was used to detect the biomechanical parameters of uremic cardiomyopathy (UCM) patients with uremic cardiomyopathy. Methods: 67 patients with UCM were randomly divided into subgroup A (n = 32) and subgroup B (n = 35). Another 30 cases were selected as normal control group. The clinical cardiac function score NYHA-P was compared. Left ventricular ejection fractionation (LVEF). Left ventricular mass index (LVMI). Left ventricular spherical index. Left ventricular mean radial strain (LVSI) and myocardial biomechanical parameters (mean radial straining MRS). The mean radial strain rate was mean radial strain rate.Meanwhile the mean longitudinal strain was mean longitudinal strain. MLS, tissue motion annular displacement (TMAD). Results the systolic twist of left ventricular torsion was increased in the group of LVMI, and the LVMI was increased in the group of left ventricular contractile torsion. There was no significant difference between subgroup B and subgroup A (P 0.05) and MLS MRS MRSR in group B (P 0.05). The absolute value of MLS in normal control group and UCM group was positively correlated with LVEF. The absolute value of MLS in UCM patients was positively correlated with LVSI and negatively correlated with LVMI. The sensitivity of NYHA-P4 score was 90.5% with MLS 14.10% as cut-off point. The specificity was 71%. The peak Yuedden index of 0.585.UCM patients with myocardial systolic STA was lower than that of the control group (P 0.05). Conclusion: measuring myocardial biomechanical parameters by 2 D-STI technique has unique advantages in evaluating left ventricular regional function in patients with UCM. There was no direct correlation between left ventricular hypertrophy and ventricular deformation. The clinical cardiac function grade was correlated with left ventricular hypertrophy and ventricular deformation, especially with regional cardiac function parameters. The changes of local myocardial mechanical parameters were found in patients with good cardiac function grade and mild degree of ventricular remodeling. The decrease of local myocardial mechanical parameters indicated the development of cardiac function towards abnormality.
【作者單位】: 中山大學(xué)附屬汕頭醫(yī)院超聲科;
【基金】:廣東省醫(yī)學(xué)科研基金(A2010584)~~
【分類號】:R445.1;R542.2;R692.5
【正文快照】: Effect of left ventricular hypertrophy and deformation oncardiac function in patients with uremia cardiomyopathy byusing quantitative speckle tracking technologyZHENG Yi,YANG Xiaohong,ZHOU Qiping,HUANG Yaoyao,ZHANG Fan,WANG Liangyu(Department of Ultrasou
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