本文關(guān)鍵詞：遵義漢族人群載脂蛋白A5基因多態(tài)性與高膽固醇血癥的關(guān)系　出處：《中國動(dòng)脈硬化雜志》2017年05期 　論文類型：期刊論文

  更多相關(guān)文章： 載脂蛋白A基因 c.G/T位點(diǎn)多態(tài) 高膽固醇血癥 遵義漢族人群 血脂指標(biāo)比值

【摘要】：目的探討載脂蛋白A5(Apo A5)基因c.553G/T位點(diǎn)多態(tài)性與遵義漢族人群高膽固醇血癥(HTC)的相關(guān)性。方法采用聚合酶鏈反應(yīng)限制性片長多態(tài)性(PCR-RFLP)技術(shù)檢測(cè)并分析101例HTC患者和118例正常對(duì)照者Apo A5基因c.553G/T位點(diǎn)多態(tài)性。結(jié)果兩組中Apo A5基因c.553G/T位點(diǎn)基因型頻率差異有統(tǒng)計(jì)學(xué)意義(P0.05),Apo A5 c.553T基因在HTC患者組中的分布頻率明顯高于正常對(duì)照組(P0.05),對(duì)HTC有獨(dú)立影響(OR=4.685,95%CI:1.269~17.296,P=0.020);各血脂指標(biāo)比較更進(jìn)一步驗(yàn)證血脂指標(biāo)比值比單相血脂檢測(cè)更具臨床意義。結(jié)論 Apo A5 c.553G/T位點(diǎn)多態(tài)性與遵義漢族人群HTC發(fā)病存在相關(guān)性;Apo A5 c.553T等位基因可能是HTC的獨(dú)立危險(xiǎn)因素。
[Abstract]:Objective to investigate the relationship between the polymorphism of apolipoprotein A5 apo A5) gene c. 553 G / T and hypercholesterolemia in Zunyi Han population. Methods Polymerase chain reaction restriction fragment length polymorphism PCR-RFLP was used. The polymorphism of Apo A5 gene c. 553 G / T locus in 101 patients with HTC and 118 normal controls was detected and analyzed. Results Apo was detected in both groups. The genotype frequencies of A5 gene c. 553G / T locus were significantly different (P < 0.05). P0.05). The distribution frequency of Apo A5 c. 553T gene in HTC group was significantly higher than that in normal control group (P0. 05), and had an independent effect on HTC. 95 CI: 1.269, 17.296, Pu, 0.020; The ratio of blood lipid index is more significant than that of monophasic blood lipid detection. Conclusion Apo A5 is more important than monophasic blood lipid detection. The polymorphism of c. 553 G / T locus was associated with the incidence of HTC in Zunyi Han population. Apo A 5 c. 553 T allele may be an independent risk factor for HTC.
【作者單位】： 遵義醫(yī)學(xué)院附屬醫(yī)院檢驗(yàn)科;遵義醫(yī)學(xué)院;遵義醫(yī)學(xué)院醫(yī)學(xué)遺傳學(xué)教研室;
【基金】：貴州省科技廳項(xiàng)目(黔科合J字LKZ[2012]39號(hào)) 遵義醫(yī)學(xué)院大學(xué)生創(chuàng)新創(chuàng)業(yè)訓(xùn)練計(jì)劃項(xiàng)目(院發(fā)[2014]5828)
【分類號(hào)】：R440;R589.2
【正文快照】： 高脂血癥是由遺傳和環(huán)境因素共同作用而產(chǎn)生的一種全身性疾病。臨床上根據(jù)血液生化檢測(cè)結(jié)果將高脂血癥分為高甘油三酯血癥(hypertriglyceridemia,HTG)、高膽固醇血癥(hyper total cholesterolemia,HTC)、混合型高脂血癥(mixed hyperlipidemia)和低高密度脂蛋白血癥(low high d

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