基于支持向量機(jī)的無創(chuàng)血糖檢測電極影響研究
發(fā)布時間：2019-04-24 18:14
【摘要】：伴隨著生活水平的逐步提高,糖尿病成為了人群中的常見疾病,對預(yù)防糖尿病和一系列并發(fā)癥的發(fā)生具有很重要的意義的是能及早地檢測出血糖異�；虮O(jiān)控血糖的日常變化,而有創(chuàng)檢測或微創(chuàng)檢測的檢測方法使糖尿病患者的身心遭受到了巨大的痛苦。因此,無創(chuàng)血糖檢測技術(shù)在自我檢測方法中具有更好的應(yīng)用前景。目前的無創(chuàng)血糖檢測方法多種多樣,由于電磁波法檢測葡萄糖濃度的可靠性及穩(wěn)定性,所以本文的研究以電磁波檢測法為支撐。我國無創(chuàng)血糖檢測技術(shù)研究起步較遲,主要是以大學(xué)科研形式存在。近年來,北京大學(xué)、清華大學(xué)、天津大學(xué)、西安交通大學(xué)、中國醫(yī)科大學(xué)、中國科學(xué)院合肥智能機(jī)械研究所、第三軍醫(yī)大學(xué)等都開展了利用光學(xué)譜的無創(chuàng)血糖檢測技術(shù)的基礎(chǔ)研究。黃嵐等人曾利用近紅外漫反射光譜技術(shù),采用傅立葉變換光譜儀進(jìn)行無創(chuàng)定量檢測血糖濃度的研究。此外莫希等人以光譜測量法為理論依據(jù),建立了血糖無創(chuàng)檢測的數(shù)理模型。國外利用電磁波進(jìn)行無創(chuàng)血糖檢測主要是采用微波頻段進(jìn)行檢測。如日本Kokushikan大學(xué)的Y.Nikawa等人對微波檢測法作了深入的研究,他們發(fā)現(xiàn)高于30 GHz的電磁波對人體組織來說,介電損耗表現(xiàn)為主要因素。然而,采用電磁波進(jìn)行的無創(chuàng)血糖檢測方法均未考慮電極尺寸和形狀對檢測結(jié)果的影響,所以本課題開展的主要工作為:1.分析目前全球糖尿病的患病現(xiàn)狀及其危害,以及無創(chuàng)血糖檢測技術(shù)的研究現(xiàn)狀及成果,重點(diǎn)研究基于電磁波的無創(chuàng)血糖檢測方法。2.無創(chuàng)血糖檢測(基于電磁波的)國外現(xiàn)有的方法一般在高頻段,可穿戴式設(shè)備大都與人體接觸較頻繁,則應(yīng)使其工作頻率在安全范圍內(nèi),應(yīng)選擇合適的檢測頻段。3.國外基于電磁波的無創(chuàng)血糖研究選擇S11或S21參數(shù)作為研究對象,本研究需對S參數(shù)做實(shí)驗(yàn)對比分析選取合適的S參數(shù)。4.現(xiàn)有的基于電磁波的無創(chuàng)血糖檢測未考慮電極尺寸和形狀對檢測結(jié)果的影響,所以通過比較不同尺寸和不同形狀的電極在模擬血糖溶液中的S參數(shù),確定其對血糖檢測的影響。5.利用libsvm算法對不同尺寸、形狀電極的S參數(shù)值進(jìn)行分類,驗(yàn)證實(shí)驗(yàn)結(jié)論的正確性。研究已取得進(jìn)展:根據(jù)實(shí)驗(yàn)方案選定檢測頻段和S參數(shù),并進(jìn)行不同形狀、尺寸電極的實(shí)驗(yàn),分析實(shí)驗(yàn)數(shù)據(jù)表明電極形狀、尺寸對S參數(shù)存在影響,且一定形狀、大小的電極對S參數(shù)表現(xiàn)出一定規(guī)律,并對檢測結(jié)果更理想。對實(shí)驗(yàn)所得的S參數(shù)進(jìn)行SVM的分類算法驗(yàn)證,屬于不同尺寸、形狀電極的S參數(shù)值能被設(shè)計的分類器以較高正確率分類,驗(yàn)證了實(shí)驗(yàn)結(jié)果的正確性,即證明了電極的尺寸和形狀對無創(chuàng)血糖檢測存在影響,今后利用S參數(shù)進(jìn)行無創(chuàng)血糖檢測時設(shè)計合適形狀、尺寸的電極,這對無創(chuàng)血糖檢測精度的提高有一定的實(shí)際意義。
[Abstract]:With the gradual improvement of living standards, diabetes has become a common disease in the population, it is very important to prevent diabetes and a series of complications is to detect blood glucose abnormalities or monitor the daily changes of blood glucose as early as possible. Invasive or minimally invasive tests have caused enormous physical and mental pain in diabetic patients. Therefore, the non-invasive blood glucose detection technique has a better application prospect in the self-detection method. There are a variety of non-invasive blood glucose detection methods at present. Because of the reliability and stability of electromagnetic wave detection of glucose concentration, the research in this paper is supported by electromagnetic wave detection. The research on non-invasive blood glucose detection technology in China started late, mainly in the form of university scientific research. In recent years, Peking University, Tsinghua University, Tianjin University, Xi'an Jiaotong University, China Medical University, Hefei Institute of Intelligent Machinery, Chinese Academy of Sciences, The third military Medical University has carried out the basic research of non-invasive blood glucose detection technology using optical spectrum. Huang Lan and others used near-infrared diffuse reflectance spectroscopy to study the noninvasive quantitative detection of blood glucose concentration by Fourier transform spectrometer. In addition, based on spectral method, Moshi et al established a mathematical model for noninvasive detection of blood glucose. Non-invasive blood glucose detection by electromagnetic wave in foreign countries is mainly carried out in microwave frequency band. For example, Y.Nikawa of Kokushikan University in Japan has done in-depth research on microwave detection. They found that the dielectric loss of electromagnetic waves higher than 30 GHz is the main factor for human tissues. However, the non-invasive blood glucose detection methods using electromagnetic wave do not take into account the influence of electrode size and shape on the detection results, so the main work of this paper is as follows: 1. The present situation and harm of diabetes mellitus in the world and the research status and achievements of non-invasive blood glucose detection technology are analyzed, and the non-invasive blood glucose detection method based on electromagnetic wave is mainly studied. 2. Non-invasive blood glucose detection (based on electromagnetic wave) existing methods abroad generally in the high-frequency segment, wearable devices most of the more frequent contact with the human body, it should be made its working frequency within the safe range, should choose the appropriate detection band. 3. S11 or S21 parameters are selected as the research object in non-invasive blood sugar research based on electromagnetic wave in foreign countries. In this study, we need to do experimental comparative analysis on S parameters and select appropriate S parameters. 4. The existing non-invasive blood glucose detection based on electromagnetic wave does not take into account the influence of electrode size and shape on the detection results, so by comparing the S parameters of electrodes with different sizes and shapes in simulated glucose solution, Determine its effect on blood glucose detection. 5. The S parameters of different size and shape electrodes were classified by libsvm algorithm to verify the correctness of the experimental results. According to the experimental scheme, the detection frequency band and S parameters are selected, and the experiments of different shapes and sizes of electrodes are carried out. The analysis of experimental data shows that the shape and size of the electrode have influence on the S parameters, and the shape of the electrode has a certain shape. The size electrode shows a certain rule for S parameters, and the detection results are more satisfactory. The experimental S parameters are verified by SVM classification algorithm. The S parameter values of the shape electrode can be classified by the designed classifier with high accuracy, and the correctness of the experimental results is verified by the S parameter values of the shape electrode. That is to say, it is proved that the size and shape of the electrode have influence on the noninvasive blood glucose detection. In the future, the suitable shape and size of the electrode are designed when the S parameter is used to detect the noninvasive blood glucose, which is of practical significance to the improvement of the accuracy of the non-invasive blood glucose detection.
【學(xué)位授予單位】：成都理工大學(xué)
【學(xué)位級別】：碩士
【學(xué)位授予年份】：2017
【分類號】：R587.1;TP18
本文編號：2464672
[Abstract]:With the gradual improvement of living standards, diabetes has become a common disease in the population, it is very important to prevent diabetes and a series of complications is to detect blood glucose abnormalities or monitor the daily changes of blood glucose as early as possible. Invasive or minimally invasive tests have caused enormous physical and mental pain in diabetic patients. Therefore, the non-invasive blood glucose detection technique has a better application prospect in the self-detection method. There are a variety of non-invasive blood glucose detection methods at present. Because of the reliability and stability of electromagnetic wave detection of glucose concentration, the research in this paper is supported by electromagnetic wave detection. The research on non-invasive blood glucose detection technology in China started late, mainly in the form of university scientific research. In recent years, Peking University, Tsinghua University, Tianjin University, Xi'an Jiaotong University, China Medical University, Hefei Institute of Intelligent Machinery, Chinese Academy of Sciences, The third military Medical University has carried out the basic research of non-invasive blood glucose detection technology using optical spectrum. Huang Lan and others used near-infrared diffuse reflectance spectroscopy to study the noninvasive quantitative detection of blood glucose concentration by Fourier transform spectrometer. In addition, based on spectral method, Moshi et al established a mathematical model for noninvasive detection of blood glucose. Non-invasive blood glucose detection by electromagnetic wave in foreign countries is mainly carried out in microwave frequency band. For example, Y.Nikawa of Kokushikan University in Japan has done in-depth research on microwave detection. They found that the dielectric loss of electromagnetic waves higher than 30 GHz is the main factor for human tissues. However, the non-invasive blood glucose detection methods using electromagnetic wave do not take into account the influence of electrode size and shape on the detection results, so the main work of this paper is as follows: 1. The present situation and harm of diabetes mellitus in the world and the research status and achievements of non-invasive blood glucose detection technology are analyzed, and the non-invasive blood glucose detection method based on electromagnetic wave is mainly studied. 2. Non-invasive blood glucose detection (based on electromagnetic wave) existing methods abroad generally in the high-frequency segment, wearable devices most of the more frequent contact with the human body, it should be made its working frequency within the safe range, should choose the appropriate detection band. 3. S11 or S21 parameters are selected as the research object in non-invasive blood sugar research based on electromagnetic wave in foreign countries. In this study, we need to do experimental comparative analysis on S parameters and select appropriate S parameters. 4. The existing non-invasive blood glucose detection based on electromagnetic wave does not take into account the influence of electrode size and shape on the detection results, so by comparing the S parameters of electrodes with different sizes and shapes in simulated glucose solution, Determine its effect on blood glucose detection. 5. The S parameters of different size and shape electrodes were classified by libsvm algorithm to verify the correctness of the experimental results. According to the experimental scheme, the detection frequency band and S parameters are selected, and the experiments of different shapes and sizes of electrodes are carried out. The analysis of experimental data shows that the shape and size of the electrode have influence on the S parameters, and the shape of the electrode has a certain shape. The size electrode shows a certain rule for S parameters, and the detection results are more satisfactory. The experimental S parameters are verified by SVM classification algorithm. The S parameter values of the shape electrode can be classified by the designed classifier with high accuracy, and the correctness of the experimental results is verified by the S parameter values of the shape electrode. That is to say, it is proved that the size and shape of the electrode have influence on the noninvasive blood glucose detection. In the future, the suitable shape and size of the electrode are designed when the S parameter is used to detect the noninvasive blood glucose, which is of practical significance to the improvement of the accuracy of the non-invasive blood glucose detection.
【學(xué)位授予單位】：成都理工大學(xué)
【學(xué)位級別】：碩士
【學(xué)位授予年份】：2017
【分類號】：R587.1;TP18
【參考文獻(xiàn)】
相關(guān)期刊論文 前2條
1 谷歆海;;網(wǎng)絡(luò)分析儀的工作原理及在測量領(lǐng)域的應(yīng)用[J];電子工程師;2008年07期
2 高榮強(qiáng),范世福;現(xiàn)代近紅外光譜分析技術(shù)的原理及應(yīng)用[J];分析儀器;2002年03期
相關(guān)博士學(xué)位論文 前1條
1 盧宗武;基于脈搏波阻抗譜的血液電特性無創(chuàng)檢測[D];天津大學(xué);2007年
相關(guān)碩士學(xué)位論文 前3條
1 盧玉婷;基于SVM的閘機(jī)目標(biāo)識別方法的研究[D];南京理工大學(xué);2013年
2 付莉;面向?qū)ο蟮母叻直媛蔬b感圖像分類[D];電子科技大學(xué);2012年
3 杜大莉;基于阻抗信息的乳腺組織BP網(wǎng)絡(luò)識別方法[D];天津大學(xué);2008年
，本文編號：2464672
本文鏈接：http://sikaile.net/kejilunwen/zidonghuakongzhilunwen/2464672.html
最近更新
教材專著
