本文選題：非接觸式技術(shù) + 智能移動設(shè)備　； 參考：《東南大學(xué)》2017年碩士論文

【摘要】：非接觸式技術(shù)在生物傳感器中具有廣泛的應(yīng)用,它與生物傳感器的結(jié)合,避免了直接接觸造成的二次污染,省去了更換相關(guān)裝置的麻煩,降低了實(shí)驗(yàn)和觀測的成本,增加了傳感器應(yīng)用場合的靈活性,使得24小時連續(xù)監(jiān)測成為可能。但是目前的非接觸式技術(shù)比較復(fù)雜,與之結(jié)合使用的電路單元或者儀器設(shè)備較為龐大,不便于隨身攜帶,基于智能移動設(shè)備的非接觸式技術(shù)與生物傳感器結(jié)合,是醫(yī)療健康領(lǐng)域技術(shù)發(fā)展的一個重要方向。本文中,我們將智能手機(jī)與非接觸式技術(shù)結(jié)合起來應(yīng)用于生物傳感器中,制備出更加智能化、小型化的生物傳感器。研究工作的內(nèi)容可分為以下三個部分:一、在傳感器的信號檢測環(huán)節(jié),利用基于手機(jī)攝像頭的光學(xué)檢測,并應(yīng)用在唾液淀粉酶檢測中。設(shè)計(jì)了用于唾液淀粉酶檢測的紙芯片并選擇EPS速率法進(jìn)行淀粉酶檢測;開發(fā)了基于android手機(jī)的用于芯片比色檢測的APP,選擇合適的算法對目標(biāo)區(qū)域進(jìn)行識別和檢測。制備出的芯片可以進(jìn)行批量生產(chǎn),且這種檢測方法不受檢測樣品數(shù)量的限制。二、在傳感器的能量供應(yīng)環(huán)節(jié),利用電磁感應(yīng)無線充電技術(shù)為分析芯片供電,并應(yīng)用于乳酸檢測中。從提高無線傳輸效率的角度入手,設(shè)計(jì)了能量發(fā)射電路、接收電路及無線PCB線圈,制作出在傳輸距離5mm以內(nèi),輸出電壓在0.9～1.5V之間的無線充電系統(tǒng);設(shè)計(jì)了基于電致變色的傳感器陣列,調(diào)節(jié)電致變色材料普魯士藍(lán)中存儲的電量控制乳酸的檢測限;制備的乳酸檢測芯片可以直接通過裸眼讀取普魯士藍(lán)點(diǎn)陣變無色的個數(shù)進(jìn)行半定量檢測。三、在傳感器的信號傳輸環(huán)節(jié),利用無線WiFi技術(shù)進(jìn)行離子濃度的檢測,設(shè)計(jì)了可穿戴設(shè)備的雛形。利用柔性PCB板制作了離子檢測傳感器的數(shù)據(jù)采集和傳輸電路,利用手機(jī)WiFi接收傳輸?shù)臄?shù)據(jù)進(jìn)行計(jì)算和顯示,并傳輸至服務(wù)器進(jìn)行存儲。
[Abstract]:Non-contact technology is widely used in biosensors. The combination of non-contact technology and biosensor avoids the secondary pollution caused by direct contact, saves the trouble of replacing related devices, and reduces the cost of experiment and observation. The flexibility of sensor applications is increased, and 24-hour continuous monitoring is possible. However, the current non-contact technology is more complex, and the circuit unit or instrument equipment used with it is relatively large, which is not easy to carry around. The non-contact technology based on intelligent mobile device is combined with biosensor. It is an important direction of technical development in the field of medical and health. In this paper, we combine smart phone and contactless technology into biosensor to produce a more intelligent and miniaturized biosensor. The research work can be divided into the following three parts: first, in the sensor signal detection, using the camera based on mobile phone optical detection, and the application in saliva amylase detection. The paper chip for saliva amylase detection was designed and the EPS rate method was selected to detect the amylase. The app for chip colorimetric detection based on android mobile phone was developed and the appropriate algorithm was selected to identify and detect the target area. The chip can be produced in batch, and the detection method is not limited by the number of samples. Secondly, in the energy supply link of the sensor, the electromagnetic induction wireless charging technology is used to supply power for the analysis chip, and it is applied to the detection of lactic acid. In order to improve the wireless transmission efficiency, the energy transmitting circuit, the receiving circuit and the wireless PCB coil are designed, and the wireless charging system with output voltage between 0.9V and 1.5V is made within the transmission distance 5mm. A sensor array based on electrochromic method was designed to adjust the detection limit of lactic acid stored in the electrochromic material Prussian Blue. The prepared lactic acid detection chip can be used to detect the number of colorless Prussian blue dots directly through naked eyes. Thirdly, in the signal transmission link of sensor, using wireless WiFi technology to detect ion concentration, the prototype of wearable device is designed. The data acquisition and transmission circuit of ion detection sensor is made by using flexible PCB board. The data received and transmitted by mobile phone WiFi is calculated and displayed and transmitted to the server for storage.
【學(xué)位授予單位】：東南大學(xué)
【學(xué)位級別】：碩士
【學(xué)位授予年份】：2017
【分類號】：TP212.3

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