本文選題：青光眼　切入點：可植入式　出處：《南昌航空大學》2017年碩士論文

【摘要】：眼壓信號是青光眼患者特別是重癥青光眼患者需要實時、準確監(jiān)測的一項非常重要的生理信號。目前醫(yī)院常用的眼壓測量儀器,由于其尺寸大,無法連續(xù)監(jiān)測且需要外人協(xié)助測量等因素的影響,無法滿足患者24小時眼壓較為準確、方便地測量。為此,本文研究了一種可植入式柔性眼壓傳感器用于青光眼患者的眼壓長時間連續(xù)監(jiān)測,并且主要圍繞眼壓傳感器的工作原理、結構設計、工藝制作、測控系統(tǒng)、表征和性能測試等方面進行研究。本文首先分析總結了國內外可植入式眼壓傳感器和柔性壓力傳感器的研究現(xiàn)狀并提出了一種基于微納接觸敏感機制的電容式壓力傳感器。這種微納接觸敏感結構的電容式壓力傳感器受壓力作用后,具有易變形、介電常數(shù)變化大的特點,因此能夠提高傳感器的靈敏度。根據(jù)傳感器的原理、結構設計和可植入的特殊應用,本文選用了可生物兼容的材料,并且主要研究了兩種微納接觸結構的電容式壓力傳感器的制作工藝。一種是利用規(guī)則的金字塔結構,另一種是利用多壁碳納米管制作微納接觸結構。綜合分析比較了兩種方法的優(yōu)缺點,并重點對多壁碳納米管制作的微納接觸結構的電容式壓力傳感器進行研究。傳感器的測控系統(tǒng)也是本文的重要研究內容,它主要由密封腔體、環(huán)境控制模塊、信號處理模塊組成�？紤]到眼壓的特殊環(huán)境,本文設計、制作的密封腔體和環(huán)境控制模塊能夠控制密封腔體內的壓力、溫度等環(huán)境因素。信號處理模塊主要包括電容檢測電路和電子測量儀器,用于檢測和傳輸傳感器的信號。此外,設計、制作的固態(tài)壓力系統(tǒng),用于傳感器對固態(tài)壓力的響應。建立的傳感器測控系統(tǒng)能滿足眼壓傳感器的性能測試和模擬體內眼壓環(huán)境的要求。最后通過高精密測量儀器和傳感器測控系統(tǒng)對傳感器進行表征和性能測試。實驗結果表明,本文研究的基于微納接觸敏感結構的電容式壓力傳感器具有良好的穩(wěn)定性、重復性、遲滯,傳感器的靈敏度可達1.3/kPa,傳感器對微小壓力的響應時間達到毫秒級,并且不易受溫度的影響。這種高性能的可植入式柔性眼壓傳感器,經(jīng)過合適的封裝后,不僅適用于體內眼壓的測量,而且也會有力地推進新型微傳感器在醫(yī)療、健康監(jiān)測、移動健康服務等領域的應用。
[Abstract]:The intraocular pressure signal is especially severe in patients with glaucoma glaucoma patients need real-time, a very important physiological signal monitoring accurately. At present the hospital commonly used intraocular pressure measuring instrument, because of its large size, not continuous monitoring and the influence factors such as the measurement need outside help, unable to meet the patient 24 hours intraocular pressure is more accurate, convenient for measurement. In this paper, an implantable flexible intraocular pressure sensor for glaucoma intraocular pressure long time continuous monitoring, and focuses on the working principle of the sensor, IOP structural design, fabrication, measurement and control system, studied the characterization and performance test. This article analyzes the domestic and foreign research status of implantable sensors and flexible intraocular pressure the pressure sensor and presents a capacitive pressure sensor based on micro nano touch sensitive mechanism. This kind of micro nano contact sensitivity The sense of capacitive pressure sensor structure under pressure, has the characteristics of large deformation, the variation of dielectric constant, so it can improve the sensitivity of the sensor. According to the sensor principle, structure design and special application of implantable materials can be selected, bio compatible, and mainly studies the production process of two kinds of capacitors the pressure sensor micro contact structure. One is the Pyramid structure with rules, another is the use of carbon nanotubes to make micro nano contact structure of multi wall. A comprehensive analysis and comparison of advantages and disadvantages of the two methods, and focus on the production of multi walled carbon nanotubes micro capacitive pressure sensor contact structure. Study. An important research content of measurement and control system is the sensor, which mainly comprises a sealing cavity, environment control module, signal processing module. Considering the special environment of the intraocular pressure, this paper design That made the seal chamber and the environment control module can control the sealing cavity pressure, environmental factors such as temperature. The signal processing module mainly includes the capacitance detection circuit and electronic measuring instrument, used for signal detection and transmission of the sensor. In addition, design, solid pressure production system, in response to pressure sensor on the solid-state sensor control. The establishment of the system can meet the performance test and Simulation of intraocular pressure sensor in intraocular pressure environment. Finally through the measurement and control system for high precision measuring instrument and sensor characterization and performance test of the sensor. The experimental results show that the hysteresis capacitive pressure sensor based on micro nano touch sensitive structure has good stability and repeatability. The sensitivity of the sensor can reach 1.3/kPa, the response time of the micro pressure sensor to milliseconds, and it is not affected by temperature. This high-performance implantable flexible intraocular pressure sensor is suitable for measuring intraocular pressure in vivo after proper encapsulation. It will also effectively promote the application of new microsensor in medical, health monitoring, mobile health services and other fields.

【學位授予單位】：南昌航空大學
【學位級別】：碩士
【學位授予年份】：2017
【分類號】：TP212

【參考文獻】

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1 黃雨o，

本文編號：1698321