本文選題：零熱流方法　切入點：核心溫度　出處：《合肥工業(yè)大學》2017年碩士論文　論文類型：學位論文

【摘要】：人體腦部核心溫度重要的生理參數(shù),在疾病監(jiān)測、診斷和治療中發(fā)揮重大的作用。對人體腦部核心溫度的監(jiān)測有利于疾病的早期發(fā)現(xiàn)、診斷和治療方案的決定。由于腦部的封閉性和安全的重要性,常用的溫度測量方法如直接接觸、紅外測溫不適合用于核心溫度長時間的連續(xù)檢測。本文針對這一重要問題,基于零熱流原理,使用價格低廉的MSP430單片機芯片和常見的PT100溫度傳感器設計并實現(xiàn)了一種核心溫度的檢測方案。本設計中傳感器采用兩組PT100熱敏電阻和一個精確參考電阻,采取恒流源測溫方法,通過儀表放大器AD620放大所需的溫度變化信號,最終通過MSP430采用12位的模數(shù)轉(zhuǎn)換器進行采集。在控制模塊部分對采集的數(shù)據(jù)進行處理和分析,通過比例積分控制算法實現(xiàn)對加熱模塊的控制,實現(xiàn)零熱流,最終獲取人體腦部的核心溫度。相對于傳統(tǒng)測溫設備,具有以下的優(yōu)勢:(1)采用零熱流原理,提供了一種核心溫度便攜式監(jiān)測手段,對國內(nèi)核心溫度研究方法的補充;(2)采用零熱流方法,于前額部位采集腦部核心溫度,非侵入式的無創(chuàng)的監(jiān)測方法使得核心溫度的檢測容易被接受;(3)采用恒流源方法,電路結(jié)構(gòu)簡單,并保持了熱敏電阻PT100在小溫度范圍(32-42℃)內(nèi)的線性特性,有利于提高溫度測量的精度;(4)采用電池供電,貫穿便攜式的設計理念,相對于傳統(tǒng)的監(jiān)測設備靈活,使得核心溫度檢測可以隨時隨地進行;(5)設計采用MSP430F149芯片和常見的傳感器,使得核心溫度的檢測成本大大降低;(6)設計的核心溫度采集系統(tǒng)可以獲取人體核心溫度的變化節(jié)律,對于生物鐘和慢性疾病的研究具有重要意義。為保證實驗的可靠和準確,通過恒溫水浴鍋對溫度傳感器進行校準;并采用對照實驗方法,同時使用耳溫槍和所設計的傳感器采集26名受試者的腦部核心溫度。比較實驗結(jié)果發(fā)現(xiàn)兩者核心溫度的測量結(jié)果無顯著性差異。同時,使用耳溫槍和零熱流傳感器連續(xù)采集受試者5天核心溫度,觀察核心溫度的周期變化節(jié)律。測量結(jié)果表明耳溫槍測量的核心溫度范圍為(37.06士 0.21)℃,零熱流傳感器所檢測的核心溫度的變化范圍(37.17 ± 0.24)℃。二者溫度測量結(jié)果變化趨勢,經(jīng)協(xié)方差分析發(fā)現(xiàn),相關系數(shù)ρ= 0.92 0.8,具有高度的相關性和一致性。
[Abstract]:The important physiological parameters of the core temperature of the human brain play an important role in disease monitoring, diagnosis and treatment. Monitoring the core temperature of the human brain is conducive to the early detection of diseases. Because of the importance of brain closure and safety, common temperature measurement methods such as direct contact, infrared temperature measurement are not suitable for continuous detection of core temperature for a long time. Based on the principle of zero heat flux, a kind of core temperature detection scheme is designed and realized by using cheap MSP430 chip and common PT100 temperature sensor. In this design, two groups of PT100 thermistor and one accurate reference resistor are used in the design. The method of constant current source temperature measurement is adopted to amplify the required temperature change signal through the instrument amplifier AD620, and finally the 12 bits A / D converter is used to collect the data through MSP430. The collected data are processed and analyzed in the control module. The control of the heating module is realized by the proportional integral control algorithm, and the zero heat flux is realized. Finally, the core temperature of the human brain is obtained. Compared with the traditional temperature measuring equipment, it has the following advantages: 1) adopting the zero heat flux principle. A portable monitoring method for core temperature is provided. The core temperature in the brain is collected from the frontal area by using zero heat flux method, which is a supplement to the domestic core temperature research method. The noninvasive non-invasive monitoring method makes the core temperature detection easily accepted. (3) the constant current source method is adopted, the circuit structure is simple, and the linearity of the thermistor PT100 is maintained in the small temperature range of 32-42 鈩，

本文編號：1624493