發(fā)布時(shí)間：2018-01-15 23:26

  本文關(guān)鍵詞：生物光信息處理技術(shù)研究　出處：《中國(guó)科學(xué)院大學(xué)(中國(guó)科學(xué)院上海技術(shù)物理研究所)》2017年博士論文　論文類型：學(xué)位論文

  更多相關(guān)文章： 空間生命科學(xué) 生物光信息 色彩還原 對(duì)比度拉伸 微透鏡型光場(chǎng)成像系統(tǒng)

【摘要】：隨著空間生命科學(xué)的發(fā)展和航空航天技術(shù)的進(jìn)步,人類對(duì)宇宙的探索和認(rèn)識(shí)不斷深化,空間生命科學(xué)研究的內(nèi)容和范疇日趨廣泛,在認(rèn)識(shí)生命現(xiàn)象本質(zhì)、促進(jìn)知識(shí)創(chuàng)新和技術(shù)創(chuàng)新,保障人類健康生活、促進(jìn)生物技術(shù)的創(chuàng)新發(fā)展和應(yīng)用,拓寬人類生存疆域、促進(jìn)必要技術(shù)的儲(chǔ)備和發(fā)展等方面將發(fā)揮無(wú)法替代的作用。根據(jù)空間生命科學(xué)與生物技術(shù)領(lǐng)域的研究現(xiàn)狀及發(fā)展情況,生命科學(xué)實(shí)驗(yàn)平臺(tái)以分子、細(xì)胞、組織、個(gè)體及群體等不同層次的生物樣品為研究對(duì)象,研究生物樣品的生命活動(dòng)在空間特殊環(huán)境下所發(fā)生的變化,而生物的光信息與生物的生命活動(dòng)密切相關(guān),因此對(duì)這些生物的光信息進(jìn)行準(zhǔn)確、高效、針對(duì)性強(qiáng)地處理,對(duì)生命科學(xué)研究起著非常重要的作用。本課題在這個(gè)背景下提出生物光信息處理技術(shù),主要研究?jī)?nèi)容和成果如下:1)對(duì)空間植物培養(yǎng)箱中彩色CMOS圖像傳感器獲取的生物光信息進(jìn)行色彩還原,色彩校正和色彩增強(qiáng)。通過(guò)對(duì)比不同的色彩還原、色彩校正、色彩增強(qiáng)方法,提出一種適合空間培養(yǎng)的植物圖像色彩還原,色彩校正方法。2)針對(duì)空間熒光顯微成像系統(tǒng)中獲取的動(dòng)物細(xì)胞圖像背景噪聲比較大,對(duì)比度不夠強(qiáng)的特點(diǎn),提出一種對(duì)比度拉伸方法,突出了圖像的目標(biāo)特性,提高了圖像的信噪比。3)本課題對(duì)基于微透鏡型的光場(chǎng)成像技術(shù)進(jìn)行研究,采用計(jì)算成像的方式對(duì)獲取的空間光場(chǎng)信息進(jìn)行算法處理,實(shí)現(xiàn)通過(guò)一次拍照獲取聚焦在不同深度的圖像,實(shí)現(xiàn)空間物體的三維立體重構(gòu),研究目的是為把光場(chǎng)成像技術(shù)應(yīng)用到空間生命科學(xué)研究領(lǐng)域中做鋪墊。4)在上述生物光信息處理技術(shù)研究的基礎(chǔ)上開(kāi)發(fā)基于MFC的空間生物圖像處理軟件平臺(tái),實(shí)現(xiàn)生物光信息處理的可視化和便捷化。
[Abstract]:With the development of space life science and the progress of aerospace technology, the exploration and understanding of the universe have been deepened, and the contents and categories of space life science research have become more and more extensive. To promote knowledge innovation and technological innovation, to ensure a healthy life for human beings, to promote the innovative development and application of biotechnology, and to broaden the scope of human survival. Promoting the reserve and development of necessary technologies will play an irreplaceable role. According to the current research situation and development situation of space life science and biotechnology, the life science experimental platform is based on molecules, cells and tissues. Biological samples at different levels, such as individuals and populations, are studied to study the changes of biological life activities in special space environment, and the biological light information is closely related to biological life activities. Therefore, it is very important to deal with the light information of these organisms accurately, efficiently and pertinently, which plays a very important role in the research of life science. Under this background, this paper puts forward the technology of biological light information processing. The main research contents and results are as follows: 1) Color reduction of bioluminescence information obtained by color CMOS image sensor in space plant incubator. Color correction and color enhancement. By comparing different methods of color restoration, color correction and color enhancement, a plant image color restoration suitable for space culture is proposed. Color correction method. 2) aiming at the characteristics of large background noise and low contrast of animal cell images obtained in spatial fluorescence microscopic imaging system, a contrast stretching method is proposed. Highlight the target characteristics of the image and improve the signal-to-noise ratio of the image. The algorithm is used to process the information of the spatial light field by computer imaging, and the 3D reconstruction of the spatial object can be realized by taking a photograph to obtain the image focused at different depth. The purpose of this study is to lay the groundwork for the application of light field imaging technology in the field of space life science. On the basis of the above research on the bio-optical information processing technology, the software platform of space biological image processing based on MFC is developed. The visualization and convenience of bio-optical information processing are realized.
【學(xué)位授予單位】：中國(guó)科學(xué)院大學(xué)(中國(guó)科學(xué)院上海技術(shù)物理研究所)
【學(xué)位級(jí)別】：博士
【學(xué)位授予年份】：2017
【分類號(hào)】：TP391.41;TP212

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