本文選題：原子力顯微鏡(AFM)　切入點(diǎn)：細(xì)胞　出處：《微納電子技術(shù)》2014年09期 　論文類(lèi)型：期刊論文

【摘要】：原子力顯微鏡(AFM)能夠以高分辨率和高靈敏度實(shí)現(xiàn)液體環(huán)境下活細(xì)胞的操作和檢測(cè),利用AFM力曲線測(cè)量功能還可以獲得細(xì)胞力學(xué)特性的相關(guān)信息。在簡(jiǎn)要介紹AFM力曲線測(cè)量原理的基礎(chǔ)上,從細(xì)胞的楊氏模量、硬度和配體-受體之間相互作用力三個(gè)方面,詳細(xì)闡述了近年來(lái)AFM在細(xì)胞力學(xué)特性研究中的發(fā)展?fàn)顩r,并著重介紹了其在細(xì)胞楊氏模量研究中的進(jìn)展,表明AFM已經(jīng)成為細(xì)胞力學(xué)特性研究中重要的生物顯微技術(shù)。最后,針對(duì)AFM的不足及局限性,提出了目前存在的問(wèn)題,并對(duì)AFM在細(xì)胞力學(xué)特性研究中的前景進(jìn)行了展望。
[Abstract]:Atomic Force microscope (AFM) enables the operation and detection of living cells in liquid environments with high resolution and sensitivity. On the basis of a brief introduction to the measurement principle of AFM force curve, the cell's Young's modulus, hardness and ligand-receptor interaction force can be obtained from three aspects: the Young's modulus of the cell, the hardness of the cell and the interaction between the ligand and the receptor, based on a brief introduction of the measurement principle of the AFM force curve. The development of AFM in the study of cellular mechanical properties in recent years was reviewed in detail, and its progress in the study of cell Young's modulus was emphasized. The results show that AFM has become an important biomicroscopic technique in the study of cellular mechanical properties. In view of the shortcomings and limitations of AFM, the existing problems are put forward, and the prospect of AFM in the study of cellular mechanical properties is prospected.
【作者單位】： 長(zhǎng)春理工大學(xué)電子信息工程學(xué)院;吉林省納米操縱裝配與制造國(guó)際科技合作基地;貝德福特大學(xué)計(jì)算機(jī)控制納米制造技術(shù)聯(lián)合研究中心;
【基金】：國(guó)家國(guó)際科技合作計(jì)劃資助項(xiàng)目(2012DFA11070) 歐盟第七研究框架計(jì)劃資助項(xiàng)目(269219,318971) 吉林省科技計(jì)劃資助項(xiàng)目(20100703,20102,201215136) 長(zhǎng)春市科技計(jì)劃資助項(xiàng)目(10GH15,11KP04)
【分類(lèi)號(hào)】：TH742
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本文編號(hào)：1585139