本文選題：原子力顯微鏡(AFM)　切入點：細胞　出處：《微納電子技術》2014年09期 　論文類型：期刊論文

【摘要】：原子力顯微鏡(AFM)能夠以高分辨率和高靈敏度實現(xiàn)液體環(huán)境下活細胞的操作和檢測,利用AFM力曲線測量功能還可以獲得細胞力學特性的相關信息。在簡要介紹AFM力曲線測量原理的基礎上,從細胞的楊氏模量、硬度和配體-受體之間相互作用力三個方面,詳細闡述了近年來AFM在細胞力學特性研究中的發(fā)展狀況,并著重介紹了其在細胞楊氏模量研究中的進展,表明AFM已經(jīng)成為細胞力學特性研究中重要的生物顯微技術。最后,針對AFM的不足及局限性,提出了目前存在的問題,并對AFM在細胞力學特性研究中的前景進行了展望。
[Abstract]:Atomic Force microscope (AFM) enables the operation and detection of living cells in liquid environments with high resolution and sensitivity. On the basis of a brief introduction to the measurement principle of AFM force curve, the cell's Young's modulus, hardness and ligand-receptor interaction force can be obtained from three aspects: the Young's modulus of the cell, the hardness of the cell and the interaction between the ligand and the receptor, based on a brief introduction of the measurement principle of the AFM force curve. The development of AFM in the study of cellular mechanical properties in recent years was reviewed in detail, and its progress in the study of cell Young's modulus was emphasized. The results show that AFM has become an important biomicroscopic technique in the study of cellular mechanical properties. In view of the shortcomings and limitations of AFM, the existing problems are put forward, and the prospect of AFM in the study of cellular mechanical properties is prospected.
【作者單位】： 長春理工大學電子信息工程學院;吉林省納米操縱裝配與制造國際科技合作基地;貝德福特大學計算機控制納米制造技術聯(lián)合研究中心;
【基金】：國家國際科技合作計劃資助項目(2012DFA11070) 歐盟第七研究框架計劃資助項目(269219,318971) 吉林省科技計劃資助項目(20100703,20102,201215136) 長春市科技計劃資助項目(10GH15,11KP04)
【分類號】：TH742
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本文編號：1585139