本文選題：糖尿病　切入點(diǎn)：認(rèn)知功能損害　出處：《燕山大學(xué)》2014年博士論文　論文類型：學(xué)位論文

【摘要】：糖尿病發(fā)病率及導(dǎo)致的認(rèn)知功能損害并發(fā)癥逐年升高，嚴(yán)重影響患者的生活質(zhì)量，給個(gè)人、家庭和社會(huì)造成沉重的精神和經(jīng)濟(jì)負(fù)擔(dān)。糖尿病是導(dǎo)致老年人認(rèn)知功能下降和癡呆的一個(gè)重要風(fēng)險(xiǎn)因素，糖尿病和衰老機(jī)制之間的復(fù)雜關(guān)系有待進(jìn)一步揭示。從20世紀(jì)80年代開始，人們開始關(guān)注2型糖尿病與癡呆的關(guān)系，但至今問題沒有得到解決。腦電是理解大腦的窗戶，因此應(yīng)用腦電信號(hào)研究糖尿病患者認(rèn)識(shí)功能的損害機(jī)制以及經(jīng)過康復(fù)治療后對(duì)糖尿病患者進(jìn)行跟蹤，從而加深對(duì)糖尿病誘發(fā)的認(rèn)知功能損害機(jī)制及其改善情況的認(rèn)識(shí)和理解，對(duì)指導(dǎo)糖尿病患者認(rèn)知功能損害的康復(fù)治療具有重要意義。本論文致力研究遺忘型輕度認(rèn)知功能損害2型糖尿病患者的腦電信號(hào)及事件相關(guān)腦電信號(hào)變化，主要進(jìn)行了以下研究工作： 首先，基于線性腦電信號(hào)分析，應(yīng)用功率譜及一致性方法研究了遺忘型認(rèn)知功能損害糖尿病患者各頻段各腦區(qū)靜息狀態(tài)下腦電活動(dòng)以及腦區(qū)內(nèi)及腦區(qū)間的同步性，分析了EEG線性指標(biāo)與神經(jīng)心理量表得分之間的相關(guān)性。探討了靜息態(tài)腦電信號(hào)指標(biāo)在認(rèn)知功能評(píng)估中的作用，提出了糖尿病患者認(rèn)知功能損害會(huì)表現(xiàn)出腦功能活動(dòng)降低、同步性減弱，腦電信號(hào)分析更具客觀性。 其次，，基于非線性腦電信號(hào)分析，研究了排序熵和加權(quán)排序熵值在遺忘型認(rèn)知功能損害糖尿病患者與正常對(duì)照組各個(gè)腦區(qū)的差異，以及二者隨參數(shù)變化的敏感性。介紹了熵值指標(biāo)與神經(jīng)心理量表之間的相關(guān)性。提出了加權(quán)排序熵對(duì)噪聲具有更強(qiáng)的魯棒性，其在區(qū)分兩組糖尿病患者中具有很好的實(shí)用價(jià)值。 然后，基于事件相關(guān)EEG信號(hào)，提取了ERPs和離散小波一致性特征。將時(shí)間、腦區(qū)、頻段和實(shí)驗(yàn)范式等信息相結(jié)合進(jìn)行0.1到0.9之間數(shù)據(jù)歸一化，應(yīng)用基于互信息的最大相關(guān)最小冗余分析，對(duì)以上特征提取典型變量，對(duì)兩組患者進(jìn)行分類。提出了n-back范式對(duì)γ頻段的影響更具顯著性，與遺忘型輕度認(rèn)知功能損害糖尿病患者工作記憶能力下降相關(guān)。指出Kanizsa虛幻圖刺激在區(qū)分兩組患者方面的研究仍有待進(jìn)一步進(jìn)行。 最后，應(yīng)用功率譜和全局同步索引方法分析了普拉提訓(xùn)練過程中健康大學(xué)生腦電信號(hào)，發(fā)現(xiàn)了普拉提訓(xùn)練使大腦神經(jīng)網(wǎng)絡(luò)變得更活躍，前額區(qū)和顳區(qū)的同步強(qiáng)度降低。本章為普拉提對(duì)腦功能干預(yù)的初步探討，這為普拉提應(yīng)用于大腦退化性疾病和認(rèn)知功能障礙康復(fù)的干預(yù)提供了初步依據(jù)。
[Abstract]:The incidence of diabetes and the complications of cognitive impairment are increasing year by year, which seriously affects the quality of life of the patients and gives them to individuals. Family and society have a heavy mental and economic burden. Diabetes is an important risk factor for cognitive impairment and dementia in older people. The complex relationship between diabetes and aging needs to be further revealed. Since 1980s, attention has been focused on the relationship between type 2 diabetes and dementia, but the problem remains unresolved. EEG is the window to understanding the brain. Therefore, EEG is used to study the mechanism of cognitive impairment in diabetic patients and to follow up the diabetic patients after rehabilitation, so as to deepen the understanding and understanding of the mechanism of diabetes induced cognitive impairment and its improvement. This paper is devoted to study the changes of EEG and event-related EEG in patients with amnesia mild cognitive impairment type 2 diabetes mellitus. The following studies were carried out:. Firstly, based on the linear EEG analysis, the power spectrum and consistency methods were used to study the EEG activity and the synchronism of the brain regions and regions in the patients with amnesia cognitive impairment. The correlation between EEG linear index and the scores of neuropsychological scale was analyzed. The role of resting EEG in cognitive function evaluation was discussed. It was suggested that cognitive impairment of diabetic patients would result in decreased brain function activity. Synchronization is weakened and EEG analysis is more objective. Secondly, based on the analysis of nonlinear EEG signals, the difference of order entropy and weighted ordering entropy in different brain regions of patients with amnesia cognitive impairment diabetes mellitus and normal control group was studied. The correlation between the entropy index and the neuropsychological scale is introduced. The weighted ranking entropy is more robust to the noise, which has a good practical value in differentiating the two groups of diabetic patients. Then, based on the event-related EEG signal, the consistency features of ERPs and discrete wavelet are extracted, and the information of time, brain region, frequency band and experimental paradigm are combined to normalize the data between 0.1 and 0.9. Using the maximum correlation minimum redundancy analysis based on mutual information to extract the typical variables from the above features and classify the two groups of patients, it is proposed that the n-back normal form has a more significant effect on the 緯 band. It is pointed out that the study of Kanizsa illusory stimulation in differentiating the two groups needs to be carried out further. Finally, using power spectrum and global synchronous index method to analyze the EEG of healthy college students during Pilates training, it is found that Pilates training makes the neural network more active. This chapter is a preliminary study on the intervention of Pilates on brain function, which provides a preliminary basis for the intervention of Pilates in the rehabilitation of brain degenerative diseases and cognitive dysfunction.
【學(xué)位授予單位】：燕山大學(xué)
【學(xué)位級(jí)別】：博士
【學(xué)位授予年份】：2014
【分類號(hào)】：R587.1;TN911.6

【參考文獻(xiàn)】

相關(guān)期刊論文 前8條

1 黃進(jìn)瑜;;腦白質(zhì)疏松與認(rèn)知功能障礙關(guān)聯(lián)分析[J];當(dāng)代醫(yī)學(xué);2013年14期

2 丁新生,程虹,張雪玲,王琨,王穎,姚娟,鄧曉萱,董海蓉;腦脊液中β淀粉樣蛋白檢測(cè)對(duì)老年期癡呆的診斷意義[J];臨床神經(jīng)病學(xué)雜志;2001年01期

3 楊志秀;羅麗華;尚正良;高玉婷;王建林;;糖尿病患者M(jìn)RI表現(xiàn)與認(rèn)知功能障礙分析[J];中國(guó)實(shí)用神經(jīng)疾病雜志;2012年24期

4 高霞;張紅霞;高聆;陳青;姜秀云;管慶波;趙家軍;;2型糖尿病患者輕度認(rèn)知功能障礙和血清AGEs水平的關(guān)系[J];山東大學(xué)學(xué)報(bào)(醫(yī)學(xué)版);2009年09期

5 ;The Relationship between Glucose Excursion and Cognitive Function in Aged Type 2 Diabetes Patients[J];Biomedical and Environmental Sciences;2012年01期

6 ;Inter- and intra-hemispheric EEG coherence in patients with mild cognitive impairment at rest and during working memory task[J];Journal of Zhejiang University Science;2006年05期

7 趙彬;商秀麗;何志義;范國(guó)光;劉虎;;阿爾茨海默病的靜息態(tài)功能磁共振成像低頻振幅研究[J];中國(guó)醫(yī)科大學(xué)學(xué)報(bào);2012年04期

8 劉振;呂奇志;;急性腦卒中患者認(rèn)知障礙與CT圖象病變位置相關(guān)性分析[J];中國(guó)實(shí)用醫(yī)藥;2011年01期

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