【摘要】：微流體的驅(qū)動(dòng)與控制是微流動(dòng)分析系統(tǒng)中一個(gè)關(guān)鍵課題。在諸多微型泵中,電滲泵(EOP)是利用電滲流實(shí)現(xiàn)液體的驅(qū)動(dòng),具有易于制作、無(wú)活動(dòng)活塞、流量穩(wěn)定、輸出壓力高等優(yōu)點(diǎn),受到越來(lái)越多的關(guān)注。本論文旨在發(fā)展電滲泵泵體制作技術(shù)及相應(yīng)的色譜接口應(yīng)用于色譜系統(tǒng)。 發(fā)展了一種簡(jiǎn)便、快捷的新型硅膠凝膠柱制備方法并將其用于電滲泵；硅膠整體柱整個(gè)制備過(guò)程少于4 h,所制備整體柱具有高柱壓降、高電阻等優(yōu)勢(shì),非常適合用于電滲泵；對(duì)該電滲泵性能進(jìn)行了系列評(píng)價(jià),包括電流、流速、壓力等參數(shù)與施加電壓之間的關(guān)系等,證明其具有良好的性能。 為提高電滲泵的輸出壓力,提出一種新型的級(jí)聯(lián)電滲泵：首先通過(guò)優(yōu)化單體、致孔劑的比例等條件分別制作出陰離子型和陽(yáng)離子型毛細(xì)管整體柱；將陰、陽(yáng)離子型毛細(xì)管整體柱交替連接即可組合成一新型級(jí)聯(lián)電滲泵。利用陰陽(yáng)離子型毛細(xì)管整體柱表面電荷的差異可實(shí)現(xiàn)級(jí)聯(lián)電滲泵施加電場(chǎng)方向的自然切換,避免了常規(guī)級(jí)聯(lián)電滲泵施加電場(chǎng)不易切換的弊端；并對(duì)該級(jí)聯(lián)電滲泵進(jìn)行性能評(píng)價(jià)。 將硅膠整體柱電滲泵結(jié)合微型淋洗液發(fā)生器應(yīng)用于毛細(xì)管離子色譜,考察了聯(lián)用裝置的穩(wěn)定性,并成功應(yīng)用于常規(guī)陰離子分析并得到了有效分離。該思路既解決了電滲泵驅(qū)動(dòng)純水在色譜中的應(yīng)用問(wèn)題,亦可為毛細(xì)管離子色譜提供了一種新型的微泵系統(tǒng)。
[Abstract]:The drive and control of micro-fluid is a key issue in micro-flow analysis system. Electroosmotic pump (EOP) is widely used to drive liquid by electroosmotic flow (EOF). It has many advantages such as easy to manufacture, no moving piston, stable flow rate and high output pressure, which has attracted more and more attention. The purpose of this paper is to develop the manufacture technology of electroosmotic pump and the application of the corresponding chromatographic interface to the chromatographic system. A simple and fast preparation method of silica gel column was developed and used in electroosmotic pump, the whole preparation process of silica gel whole column was less than 4 h, the prepared monolithic column had the advantages of high column pressure drop and high resistance, so it was very suitable for electroosmotic pump. The performance of the electroosmotic pump is evaluated, including the relationship between current, flow rate, pressure and applied voltage. It is proved that the pump has good performance. In order to improve the output pressure of electroosmotic pump, a new type of combined electroosmotic pump was proposed. Firstly, anion and cationic capillary monolithic columns were made by optimizing monomer and pore-forming agent ratio. Cationic capillary column can be connected alternately to form a new type of combined electroosmotic pump. By using the difference of surface charge on the monolithic column of anion capillary tube, the electric field direction of the combined electroosmotic pump can be switched naturally, which avoids the disadvantage that it is difficult to change the electric field applied by the conventional electroosmotic pump, and the performance of the combined electroosmotic pump is evaluated. The silica gel monolithic column electroosmotic pump combined with a micro eluant generator was applied to capillary ion chromatography. The stability of the combined device was investigated and successfully applied to the routine anion analysis and effective separation was obtained. This idea not only solves the application problem of pure water driven by electroosmotic pump in chromatography, but also provides a new micro-pump system for capillary ion chromatography.
【學(xué)位授予單位】：華東理工大學(xué)
【學(xué)位級(jí)別】：碩士
【學(xué)位授予年份】：2011
【分類號(hào)】：TH38

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本文編號(hào)：2245167