本文選題：電致孔法 + 藥物導(dǎo)入儀��； 參考：《西北大學(xué)》2012年碩士論文

【摘要】：電致孔技術(shù)是透皮給藥的一種方法,經(jīng)過長達(dá)20多年的發(fā)展,已經(jīng)形成了一門成熟的學(xué)科。電致孔技術(shù)與其它透皮給藥技術(shù)相比,因其具有給藥簡單、效率高、電參數(shù)易控制等優(yōu)點(diǎn),在細(xì)胞生物工程、基因工程和臨床醫(yī)學(xué)試驗(yàn)等領(lǐng)域得到了廣泛的應(yīng)用。由于電致孔導(dǎo)入藥物的分子類型、導(dǎo)入效率及效果與導(dǎo)入儀器的電參數(shù)有直接關(guān)系,本論文設(shè)計(jì)了一種用于電致孔技術(shù)研究的脈沖幅度、寬度和間隔寬范圍可調(diào)的藥物導(dǎo)入儀。 論文首先介紹了電致孔技術(shù)的相關(guān)知識,討論了藥物導(dǎo)入儀的電參數(shù)對電致孔給藥效果的影響因素,對照分析了現(xiàn)有藥物導(dǎo)入儀的優(yōu)缺點(diǎn),并根據(jù)目前電致孔技術(shù)的發(fā)展提出了本設(shè)計(jì)的電參數(shù)要求。通過方案論證提出了一種基于FPGA的嵌入式藥物導(dǎo)入儀設(shè)計(jì)方案。 其次重點(diǎn)介紹了FPGA控制電路、程控放大電路和脈沖功率放大電路的設(shè)計(jì)原理及系統(tǒng)構(gòu)成。設(shè)計(jì)中發(fā)揮邏輯電路速度快、C語言處理數(shù)據(jù)能力強(qiáng)的優(yōu)點(diǎn),采用數(shù)字化SOPC解決方案在FPGA中嵌入Nios II軟核處理器實(shí)現(xiàn)系統(tǒng)的控制；采用硬件描述語言在FPGA中設(shè)計(jì)并構(gòu)建了基于直接頻率合成技術(shù)的脈沖信號發(fā)生器,實(shí)現(xiàn)了系統(tǒng)的結(jié)構(gòu)設(shè)計(jì)和裝配調(diào)試。 通過對本系統(tǒng)的仿真和測試,證明了系統(tǒng)方案的可行性。本文所設(shè)計(jì)的藥物導(dǎo)入儀具有參數(shù)調(diào)整范圍寬、體積小、維護(hù)方便、易于升級、性價(jià)比高等優(yōu)點(diǎn)。
[Abstract]:Electroporation technology is a method of transdermal drug delivery. After more than 20 years of development, it has formed a mature subject. Compared with other transdermal drug delivery technology, electroporation technology has the advantages of simple drug delivery, high efficiency and easy control of electrical parameters. It has been obtained in the field of cell biological engineering, gene engineering and clinical medicine. Extensive application. Due to the molecular types of electroporate introduction of drugs, the efficiency and effect of introduction are directly related to the electrical parameters of the imported instrument. In this paper, a kind of drug importing instrument, which is used in the study of electroporing technology, is designed for the adjustable pulse amplitude, width and interval wide range.
This paper first introduces the related knowledge of electroporing technology, discusses the influence factors of the electrical parameters of the drug importing instrument on the effect of the electroporer, compares the advantages and disadvantages of the existing drug importing instrument, and puts forward the demand for the electric parameters according to the development of the current electroporing technology. A kind of FPGA based on the scheme demonstration is put forward. Design of embedded drug introduction instrument.
Secondly, the design principle and system composition of FPGA control circuit, program control amplifier circuit and pulse power amplifying circuit are introduced. In the design, the advantages of fast logic circuit and strong data ability in C language are used in the design. The digital SOPC solution is embedded in FPGA with Nios II soft core processor to realize the control of the system; and the hardware drawing is used. The language has designed and constructed a pulse signal generator based on direct frequency synthesis technology in FPGA, and realized the structural design, assembly and debugging of the system.
Through the simulation and test of this system, the feasibility of the system scheme is proved. The drug importing instrument designed in this paper has the advantages of wide range of parameters adjustment, small volume, convenient maintenance, easy to upgrade and high cost performance.
【學(xué)位授予單位】：西北大學(xué)
【學(xué)位級別】：碩士
【學(xué)位授予年份】：2012
【分類號】：R197.39;TP368.1

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