本文選題：骨修復(fù)材料 + 鎂合金��； 參考：《成都理工大學(xué)》2017年碩士論文

【摘要】：由于醫(yī)療技術(shù)水平的大力發(fā)展,全球總?cè)丝谠诓粩嗟脑鲩L(zhǎng)并趨向于老年化,這導(dǎo)致了突發(fā)性骨折疾病的比例在不斷的增長(zhǎng)。而骨折的治療通常需要輔助支架的固定支承,為患骨組織提供相對(duì)固定的組織修復(fù)環(huán)境。因此,人們近年來對(duì)骨修復(fù)支架材料的需求在顯著增長(zhǎng)。目前臨床普遍使用的金屬骨修復(fù)材料通常需要進(jìn)行二次取出手術(shù),這給病人增加了痛苦和額外的醫(yī)療費(fèi)用。而鎂合金具有可降解性和較好的力學(xué)相容性,有望作為可降解骨修復(fù)材料對(duì)骨折進(jìn)行治療。但目前,由于鎂合金降解速率與人體患骨組織的愈合速率存在著較大的差異,導(dǎo)致在一些愈合緩慢的組織處,過快的鎂合金降解速率將導(dǎo)致其力學(xué)性能提前喪失,進(jìn)而影響患骨組織的愈合。因此本課題試圖在Mg-2Zn-0.2Mn合金的基礎(chǔ)上添加含Ca元素,并結(jié)合不同熱處理工藝對(duì)Mg-2Zn-0.2Mn合金進(jìn)行改性,以期能在一定程度上對(duì)鎂合金降解速率以及力學(xué)性能進(jìn)行調(diào)控,最后采用細(xì)胞相容性實(shí)驗(yàn)對(duì)熱處理改性鎂合金進(jìn)行細(xì)胞相容性評(píng)價(jià)。首先采用井式電阻爐熔煉了Mg-2Zn-0.2Mn-0.1Ca、Mg-2Zn-0.2Mn-0.4Ca、Mg-2Zn-0.2Mn-0.7Ca三種不同含Ca比合金,并對(duì)樣品進(jìn)行金相顯微鏡、掃描電鏡、顯微硬度檢測(cè)儀、X射線衍射儀等測(cè)試分析。結(jié)果表明,隨著含Ca比的增加,Mg-2Zn-0.2Mn-xCa合金的顯微硬度值由47.54HV增加到了61.00HV。對(duì)Mg-2Zn-0.2Mn-xCa合金的三種不同含Ca比成分樣品,采用析氫浸泡實(shí)驗(yàn)進(jìn)行分析測(cè)試。結(jié)果表明,隨著含Ca比的增加,合金的平均析氫量成先減后增的趨勢(shì)。在含Ca比為0.4%時(shí),合金具有最低的平均析氫量2.588ml/cm2/Day,而在含Ca比為0.7%時(shí),合金具有最高的平均析氫量2.993ml/cm2/Day。探究熱處理對(duì)Mg-2Zn-0.2Mn-0.1Ca、Mg-2Zn-0.2Mn-0.4Ca兩種合金的腐蝕降解速率的影響。結(jié)果表明,隨著熱處理溫度的增加,兩種合金的平均析氫量成減小的趨勢(shì)。Mg-2Zn-0.2Mn-0.1Ca合金經(jīng)過380℃、420℃熱處理后的平均析氫量分別為2.124ml/cm2/Day、1.538ml/cm2/Day,相對(duì)鑄態(tài)分別降低了28.76%、43.77%。Mg-2Zn-0.2Mn-0.4Ca合金經(jīng)過380℃、420℃熱處理后的平均析氫量分別為1.489ml/cm2/Day、1.291ml/cm2/Day,相對(duì)鑄態(tài)分別降低了42.49%、50.14%。
[Abstract]:Due to the rapid development of medical technology, the global population is increasing and tends to be aging, which leads to the increasing proportion of sudden fracture diseases. The treatment of fracture usually requires the fixed support of auxiliary scaffold to provide a relatively fixed tissue repair environment for the affected bone tissue. As a result, the demand for bone-repair scaffolds has increased significantly in recent years. Metal bone repair materials currently commonly used in clinical use usually require secondary removal, which adds pain and additional medical costs to patients. Magnesium alloy has biodegradability and good mechanical compatibility, which is expected to be used as biodegradable bone repair material to treat fracture. However, at present, the degradation rate of magnesium alloy is different from the healing rate of human bone tissue, which leads to the premature loss of mechanical properties of magnesium alloy in some slowly healing tissues. And then affect the healing of bone tissue. Therefore, this paper tries to add Ca on the basis of Mg-2Zn-0.2Mn alloy and modify Mg-2Zn-0.2Mn alloy with different heat treatment process, in order to regulate the degradation rate and mechanical properties of magnesium alloy to a certain extent. Finally, the cytocompatibility of heat treated magnesium alloy was evaluated by cytocompatibility test. Mg-2Zn-0.2Mn-0.1CaG2Zn-0.2Mn-0.2Mn-0.2Mn-0.2Mn-0.7Ca alloys with different Ca content were first melted in a well resistance furnace. The samples were analyzed by metallographic microscope, scanning electron microscope, microhardness tester and X-ray diffractometer. The results show that the microhardness of Mg-2Zn-0.2Mn-xCa alloy increases from 47.54HV to 61.00HV with the increase of Ca content. Three samples of Mg-2Zn-0.2Mn-xCa alloy with different Ca ratios were analyzed and tested by hydrogen evolution immersion test. The results show that with the increase of Ca content, the average hydrogen evolution of the alloy decreases first and then increases. The alloy has the lowest average hydrogen evolution rate of 2.588ml / cm ~ 2 / Daywhen Ca content ratio is 0.4m, while the alloy has the highest average hydrogen evolution rate of 2.993ml / cm ~ 2 / Daywhen Ca content ratio is 0.7ml / cm ~ (-2). The effect of heat treatment on corrosion degradation rate of Mg-2Zn-0.2Mn-0.2Mn-0.4Ca alloy was investigated. The results show that with the increase of heat treatment temperature, The average hydrogen evolution of Mg-2Zn-0.2Mn-0.1Ca alloy after heat treatment at 380 鈩，

本文編號(hào)：2036056