本文選題：生物膜　切入點(diǎn)：抗菌　出處：《中國(guó)表面工程》2017年03期

【摘要】：為了研究生物修飾對(duì)材料表面抗菌性能的影響,利用多巴胺及三種生物多肽修飾304不銹鋼的表面,利用傅里葉變換紅外光譜儀(FTIR)和接觸角測(cè)量?jī)x研究修飾后的材料表面性質(zhì),選用金黃色葡萄球菌(S.aureus)作為試驗(yàn)菌株研究樣本表面抗菌性能,并通過(guò)超景深三維顯微系統(tǒng)初步研究了樣本表面形貌對(duì)抗菌性能的影響。結(jié)果表明,多巴胺和生物肽修飾后,樣本表面的濕潤(rùn)性發(fā)生了改變,且都具有抗菌效果,1號(hào)多肽抗菌效果最好,多巴胺修飾樣本的抗菌效果最差;不同顆粒度砂紙、不同拋磨壓力處理的樣本表面會(huì)影響材料表面性能,600號(hào)砂紙拋光的樣本經(jīng)生物修飾后抗菌效果優(yōu)于2 000號(hào)砂紙拋光的樣本,這個(gè)結(jié)論同樣適用于開(kāi)放環(huán)境中。
[Abstract]:In order to study the effect of biological modification on the surface antibacterial properties of 304 stainless steel, dopamine and three biological peptides were used to modify the surface of 304 stainless steel. The surface properties of the modified materials were studied by Fourier transform infrared spectroscopy (FTIR) and contact angle measuring instrument.Staphylococcus aureus was selected as the experimental strain to study the antibacterial properties of the sample surface and the effect of the surface morphology of the sample on the antimicrobial activity was preliminarily studied by means of three dimensional depth of field microscopy system.The results showed that the wettability of the sample surface changed after the modification of dopamine and biopeptide, and both of them had antibacterial effect. The antibacterial effect of polypeptide No. 1 was the best, and that of dopamine modified sample was the worst.The surface properties of the samples treated with different polishing pressures will affect the surface properties of the materials. The antibacterial effect of the polished samples of 600 # sandpaper is better than that of the samples polished with 2 000 sandpaper. This conclusion is also applicable to the open environment.
【作者單位】： 武漢理工大學(xué)能源與動(dòng)力工程學(xué)院;英國(guó)基爾大學(xué)醫(yī)藥科技研究所;
【基金】：國(guó)家自然科學(xué)基金(51375355) 湖北省自然科學(xué)基金(2015CFA127) 中央高�；究蒲袠I(yè)務(wù)費(fèi)(2016-YB-023)~~
【分類(lèi)號(hào)】：TG174.4

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本文編號(hào)：1713520