Arsenic methyltransferase（As3mt） catalyzes the conversion of inorganic arsenic（i As） to its methylated metabolites, including toxic methylarsonite（MAs^Ⅲ） and dimethylarsinite（DMAs^Ⅲ）. Knockout（KO） of As3 mt was shown to reduce the capacity to methylate i As in mice. However, no data are available on the oxidation states of As species in tissues of these mice. Here, we compare the oxidation states of As species in tissues of male C57BL/6 As3mt-KO and wild-type（WT） mice exposed... 

【文章來源】：Journal of Environmental Sciences. 2016,49(11)

【文章頁數(shù)】：9 頁

【文章目錄】：
Introduction
1. Materials and methods
    1.1. Arsenicals
    1.2. Mice and treatments
    1.3. Speciation analysis of As by HG-CT-AAS
    1.4. Statistical analysis
2. Results and discussion
    2.1. Water consumption and body weights
    2.2. Effect of genotype on As speciation in tissues
    2.3. Comparison of the tissue levels of As
3. Conclusions



本文編號(hào)：3042670