【摘要】：生物活性微晶玻璃被認(rèn)為是可應(yīng)用在骨修復(fù)領(lǐng)域良好的生物材料,研究熱點主要集中于Ceravital生物活性微晶玻璃、A-W生物活性微晶玻璃和Bioverit可切削生物活性微晶玻璃。這些微晶玻璃燒結(jié)溫度高,不適宜采用快速成型工藝,因此研究和制備具有低燒結(jié)溫度的新型玻璃體系的生物活性材料具有重要的現(xiàn)實意義。實驗構(gòu)建Na2O-B2O3-SiO2-CaO-P2O5-F體系,通過調(diào)整配方組成,采用燒結(jié)法制備具有低溫?zé)Y(jié)、低溫析晶性能的生物活性微晶玻璃材料,討論材料的燒結(jié)與析晶的匹配性。研究表明引入P2O5的原料不同,獲得的氟磷灰石形貌不同,采用CaHPO4·2H2O時能獲得尺寸細(xì)小的晶體,氟磷灰石呈針狀;通過對分相區(qū)內(nèi)外不同組成點的研究發(fā)現(xiàn),玻璃中均析出氟磷灰石,但晶體形貌不同,分相區(qū)內(nèi)的組成中氟磷灰石呈針狀,分相區(qū)外的組成中氟磷灰石呈球狀或短棒狀,且分相區(qū)內(nèi)組成的析晶活化能遠(yuǎn)小于分相區(qū)外的組成,較易析晶;對于分相區(qū)內(nèi)的組成,玻璃體系很容易發(fā)生分相,分相形貌為貫通的網(wǎng)絡(luò)結(jié)構(gòu),尺寸在納米級,其形貌隨氟磷灰石的生長方向向徑向延伸;分相區(qū)內(nèi)的組成隨CaO、P2O5添加量增大,材料的結(jié)晶度增大,樣品的燒結(jié)性能與結(jié)晶度變化相匹配,在800℃熱處理,P2O5含量為24wt%時樣品的結(jié)晶度最大,顯氣孔率降至3.51%,體積密度達(dá)到2.54g/cm3,抗彎強度和彈性模量分別為65.26MPa、4.18GPa;隨熱處理溫度的提高,樣品的結(jié)晶度先增大后減小,在800℃時達(dá)到82.76%,此時各組樣品都能獲得良好的燒結(jié)效果,顯氣孔率低于5%,體積密度達(dá)2.3g/cm3以上,顯微硬度在400HV以上,抗彎強度和彈性模量分別達(dá)到55MPa、4GPa以上;模擬體液浸泡實驗證明樣品表面有富含Ca、P元素的物質(zhì)生成,證明實驗制備的微晶玻璃具有一定的生物活性。
[Abstract]:Bioactive glass-ceramics are considered to be good biomaterials in the field of bone repair. The research focuses on Ceravital bioactive glass-ceramics, A-W bioactive glass-ceramics and Bioverit bioactive glass-ceramics. These glass-ceramics are not suitable for rapid prototyping because of their high sintering temperature. Therefore, it is of great practical significance to study and prepare new type glass active materials with low sintering temperature. The Na2O-B2O3-SiO2-CaO-P2O5-F system was constructed experimentally. The bioactive glass-ceramics with low temperature sintering and low temperature crystallization properties were prepared by adjusting the composition of the formula. The matching between sintering and crystallization of the materials was discussed. The results show that the morphology of fluoroapatite is different with the introduction of P2O5. The fine crystal can be obtained by using CaHPO4 2H2O, and the fluorapatite is needle-like. Through the study of the different composition points inside and outside the phase separation zone, it is found that fluoroapatite is precipitated in glass, but the morphology of the crystal is different. The fluoroapatite in the phase separation zone is acicular, and the fluoroapatite outside the phase separation zone is spherical or short rod. The activation energy of crystallization in the phase separation region is much smaller than that outside the phase separation zone, and it is easy to crystallize. For the composition of the phase separation region, the glass system is prone to phase separation. The morphology of the glass system is a penetrating network structure and its size is in the nanometer level. The morphology of the glass system extends radial with the growth direction of fluorophosphatite. The composition of the phase separation zone increases with the increase of CaO,P2O5 content, the crystallinity of the material increases, and the sintering properties of the samples match the change of crystallinity. The crystallinity of the samples is maximum when the content of P2O5 is 24wt%, and the apparent porosity decreases to 3.51% at 800 鈩，

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