鋅鐵氧體高溫?zé)峤庵苽溲芯?/H1>
發(fā)布時(shí)間：2018-12-10 10:34
【摘要】：鋅摻雜的鐵氧體(ZnxFe1-x)Fe2O4磁性納米顆粒具有遠(yuǎn)比傳統(tǒng)Fe3O4磁性納米顆粒更強(qiáng)的磁性,更強(qiáng)的感應(yīng)升溫能力,和更高的磁共振弛豫率。因此,在生物醫(yī)學(xué)應(yīng)用,特別是腫瘤的造影和磁感應(yīng)熱療等領(lǐng)域,鋅鐵氧體具有廣泛的應(yīng)用前景和巨大的應(yīng)用潛力。在本文中,我們使用乙酰丙酮鋅和乙酰丙酮鐵作為前驅(qū)物,油酸作為表面活性劑,二芐醚作為溶劑,進(jìn)行鋅鐵氧體磁性納米顆粒的高溫?zé)峤夥ㄖ苽�。我們�?chuàng)新性地采用熱注入法來(lái)進(jìn)行鋅鐵氧體磁性納米顆粒的高溫?zé)峤庵苽?從而達(dá)到提升鋅摻雜水平的效果。我們通過(guò)一系列系統(tǒng)的實(shí)驗(yàn)和表征,對(duì)高溫?zé)峤夥ㄖ胁煌磻?yīng)條件對(duì)鋅鐵氧體磁性納米顆粒的粒徑、形貌、鋅摻雜和包括磁感應(yīng)升溫能力,飽和磁化強(qiáng)度和MRI磁共振造影r2弛豫率在內(nèi)的磁學(xué)性能的影響進(jìn)行探究。我們先保持前驅(qū)物投料量不變,觀察油酸投料量的改變對(duì)鋅鐵氧體的尺寸與形貌及鋅摻雜水平和磁學(xué)性能的影響。結(jié)果表明,隨著表面活性劑量的增加,鋅鐵氧體磁性納米顆粒的尺寸、反應(yīng)速度和鋅摻雜水平呈現(xiàn)非單調(diào)的變化趨勢(shì)。之后我們還進(jìn)行了高性能鋅鐵氧體磁性納米顆粒放量生產(chǎn)的探索,我們保持乙酰丙酮鋅：乙酰丙酮鐵：總油酸的比例不變,生長(zhǎng)溫度和升溫速率不變,僅增加油酸和乙酰丙酮鋅、乙酰丙酮鐵的投入總量,對(duì)制得的鋅鐵氧體磁性納米顆粒的尺寸、形貌、鋅摻雜水平及磁學(xué)性能進(jìn)行評(píng)估。結(jié)果表明,增加反應(yīng)物的投入總量,可以有效實(shí)現(xiàn)放量制備鋅摻雜鐵氧體磁性納米顆粒,并且獲得優(yōu)異的形貌及磁學(xué)性能。這對(duì)高性能鋅鐵氧體磁性納米顆粒高溫?zé)峤夥ǚ帕可a(chǎn)具有指導(dǎo)意義。在最后一章中,我們合成了能在317K變色的Cu(dieten)2(ClO4)2配合物分子,接下來(lái)使用一塊嵌有磁性納米顆粒的結(jié)冷膠(Gellan gel)作為組織模型,來(lái)進(jìn)行磁致熱變色的研究,從而模擬該配合物分子在腫瘤熱療熱劑量控制上的應(yīng)用。實(shí)驗(yàn)結(jié)果表明,該配合物分子變色與復(fù)色反應(yīng)靈敏,顏色變化明顯,非常適合應(yīng)用于作為腫瘤熱療熱劑量控制的一個(gè)直觀的定性的表征手段。
[Abstract]:The zinc-doped ferrite (ZnxFe1-x) Fe2O4 magnetic nanoparticles have much stronger magnetic properties than traditional Fe3O4 magnetic nanoparticles, stronger inductive heating capacity, and higher magnetic resonance relaxation rate. Therefore, zinc ferrite has a wide application prospect and great potential in biomedical applications, especially in tumor imaging and magnetic induction hyperthermia. In this paper, zinc acetylacetone and iron acetylacetone were used as precursors, oleic acid as surfactant and dibenzyl ether as solvent to prepare zinc ferrite magnetic nanoparticles by pyrolysis at high temperature. The thermal injection method was used to prepare the magnetic nanoparticles of zinc ferrite at high temperature so as to improve the doping level of zinc. Through a series of systematic experiments and characterization, the particle size, morphology, zinc doping and magnetic induction heating ability of zinc ferrite magnetic nanoparticles under different reaction conditions in pyrolysis at high temperature were investigated. The effects of saturation magnetization and MRI magnetic resonance imaging r 2 relaxation rate on magnetic properties were investigated. The influence of the amount of oleic acid on the size and morphology of zinc ferrite, zinc doping level and magnetic properties was observed. The results show that the size, reaction rate and zinc doping level of magnetic nanocrystals of zinc ferrite show a non-monotonic trend with the increase of surfactant content. Then we explored the production of high performance zinc ferrite magnetic nanoparticles. We kept the ratio of zinc acetylacetone to iron acetylacetone to total oleic acid constant, and the growth temperature and heating rate were constant. The size, morphology, zinc doping level and magnetic properties of the prepared zinc ferrite nanoparticles were evaluated by increasing the total input of oleic acid and acetylacetone zinc and iron acetylacetone. The results show that increasing the total amount of reactants can effectively realize the preparation of zinc-doped ferrite magnetic nanoparticles and obtain excellent morphology and magnetic properties. This is of guiding significance for the production of high temperature pyrolysis discharge of high performance zinc ferrite magnetic nanoparticles. In the last chapter, we synthesized Cu (dieten) _ 2 (ClO4) _ 2 complex molecules that can discolor at 317K, and then we used a chilled (Gellan gel) with magnetic nanoparticles as the structure model to study the magnetochromic discoloration. Thus, the application of the complex molecule in the hyperthermia dose control of tumor was simulated. The experimental results show that the complex is sensitive to color change and has obvious color change. It is suitable for use as an intuitive qualitative characterization method for the control of hyperthermia dose of tumor.
【學(xué)位授予單位】：東南大學(xué)
【學(xué)位級(jí)別】：碩士
【學(xué)位授予年份】：2015
【分類號(hào)】：TM277
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，
本文編號(hào)：2370429
本文鏈接：http://sikaile.net/kejilunwen/dianlilw/2370429.html
[Abstract]:The zinc-doped ferrite (ZnxFe1-x) Fe2O4 magnetic nanoparticles have much stronger magnetic properties than traditional Fe3O4 magnetic nanoparticles, stronger inductive heating capacity, and higher magnetic resonance relaxation rate. Therefore, zinc ferrite has a wide application prospect and great potential in biomedical applications, especially in tumor imaging and magnetic induction hyperthermia. In this paper, zinc acetylacetone and iron acetylacetone were used as precursors, oleic acid as surfactant and dibenzyl ether as solvent to prepare zinc ferrite magnetic nanoparticles by pyrolysis at high temperature. The thermal injection method was used to prepare the magnetic nanoparticles of zinc ferrite at high temperature so as to improve the doping level of zinc. Through a series of systematic experiments and characterization, the particle size, morphology, zinc doping and magnetic induction heating ability of zinc ferrite magnetic nanoparticles under different reaction conditions in pyrolysis at high temperature were investigated. The effects of saturation magnetization and MRI magnetic resonance imaging r 2 relaxation rate on magnetic properties were investigated. The influence of the amount of oleic acid on the size and morphology of zinc ferrite, zinc doping level and magnetic properties was observed. The results show that the size, reaction rate and zinc doping level of magnetic nanocrystals of zinc ferrite show a non-monotonic trend with the increase of surfactant content. Then we explored the production of high performance zinc ferrite magnetic nanoparticles. We kept the ratio of zinc acetylacetone to iron acetylacetone to total oleic acid constant, and the growth temperature and heating rate were constant. The size, morphology, zinc doping level and magnetic properties of the prepared zinc ferrite nanoparticles were evaluated by increasing the total input of oleic acid and acetylacetone zinc and iron acetylacetone. The results show that increasing the total amount of reactants can effectively realize the preparation of zinc-doped ferrite magnetic nanoparticles and obtain excellent morphology and magnetic properties. This is of guiding significance for the production of high temperature pyrolysis discharge of high performance zinc ferrite magnetic nanoparticles. In the last chapter, we synthesized Cu (dieten) _ 2 (ClO4) _ 2 complex molecules that can discolor at 317K, and then we used a chilled (Gellan gel) with magnetic nanoparticles as the structure model to study the magnetochromic discoloration. Thus, the application of the complex molecule in the hyperthermia dose control of tumor was simulated. The experimental results show that the complex is sensitive to color change and has obvious color change. It is suitable for use as an intuitive qualitative characterization method for the control of hyperthermia dose of tumor.
【學(xué)位授予單位】：東南大學(xué)
【學(xué)位級(jí)別】：碩士
【學(xué)位授予年份】：2015
【分類號(hào)】：TM277
【相似文獻(xiàn)】
相關(guān)期刊論文 前5條
1 靜夏;國(guó)外垃圾妙用拾趣[J];建材工業(yè)信息;1997年04期
2 包向軍,蔡九菊,羅光前,齊利娟;城市垃圾高溫?zé)峤庠囼?yàn)研究[J];工業(yè)加熱;2003年03期
3 錢(qián)原吉;吳占松;;部分固體廢物的批量高溫?zé)峤庠囼?yàn)研究[J];熱力發(fā)電;2008年01期
4 張溪文;秋艷鵬;韓高榮;;一種制備Bi-YIG納米晶薄膜的新方法(英文)[J];稀有金屬材料與工程;2008年S2期
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1 李義;竹炭粉新板材問(wèn)世[N];中國(guó)綠色時(shí)報(bào);2010年
相關(guān)博士學(xué)位論文 前1條
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1 黃一鑫;鋅鐵氧體高溫?zé)峤庵苽溲芯縖D];東南大學(xué);2015年
2 盧日鑫;廢舊液晶面板中有機(jī)材料的高溫?zé)峤庋芯縖D];上海交通大學(xué);2013年
3 祝初梅;微波高溫?zé)峤獬鞘形勰嘀亟饘俟潭ㄐ苎芯縖D];哈爾濱工業(yè)大學(xué);2007年
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，本文編號(hào)：2370429
本文鏈接：http://sikaile.net/kejilunwen/dianlilw/2370429.html
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