【摘要】：超順磁性納米粒子(SPIONs)具有超順磁性、良好的生物相容性,在腫瘤的診斷和治療方面有很大潛力。腫瘤細(xì)胞表面會特異性的表達(dá)某些表面標(biāo)志物,因此以磁性納米顆粒為核心的分子探針與腫瘤細(xì)胞表面的特異性分子標(biāo)志物相結(jié)合,可特異性的識別腫瘤并形成磁共振影像。SPIONs經(jīng)特定的配體修飾,可賦予其組織器官靶向性,通過高滲透性以及外加磁場雙效靶向來提高藥物在腫瘤部位的生物利用度,從而減少對正常細(xì)胞的毒性,提高腫瘤局部的藥物濃度。SPIONs具有很高的磁熱效應(yīng),可通過導(dǎo)熱量殺死腫瘤細(xì)胞而被用于熱療,熱療較放療和化療的副作用小。因此功能化的SPIONs必將成為臨床深受歡迎的造影劑和基于MRI的診斷和治療試劑�？偨Y(jié)了SPIONs在腫瘤診斷和治療方面的應(yīng)用,同時探討SPIONs的性質(zhì)、合成方法和表面修飾。
[Abstract]:Superparamagnetic nanoparticles (SPIONs) have great potential in the diagnosis and treatment of tumors because of their excellent biocompatibility and superparamagnetic properties. Some surface markers are specifically expressed on the surface of tumor cells, so the molecular probes with magnetic nanoparticles as the core combine with the specific molecular markers on the surface of tumor cells. SPIONs can be modified by a specific ligand to give it tissue and organ targeting, and to increase the bioavailability of drugs at tumor sites through high permeability and dual magnetic field targeting. SPIONs has a high magnetocaloric effect and can be used in hyperthermia through heat conduction to kill tumor cells. The side effects of hyperthermia are less than those of radiotherapy and chemotherapy. Therefore, functionalized SPIONs will become a popular contrast agent and diagnostic and therapeutic reagent based on MRI. The application of SPIONs in tumor diagnosis and treatment was summarized, and the properties, synthetic methods and surface modification of SPIONs were discussed.
【作者單位】： 德州學(xué)院醫(yī)藥與護(hù)理學(xué)院;
【基金】：國家自然科學(xué)基金資助項目(51273033)
【分類號】：R730.5;TB383.1

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