【摘要】：本文主要研究了新型磁性納米復(fù)合材料的合成及其作為吸附劑以及核磁共振造影劑方面的性能研究。主要研究內(nèi)容及結(jié)果如下： 1.首次通過室溫液相還原方法合成了新穎的層狀結(jié)構(gòu)的Co/Co(OH)2納米復(fù)合物，，并提出了可能在反應(yīng)中發(fā)生的反應(yīng)機制和形貌發(fā)展。對Co/Co(OH)2進行磁性測試，發(fā)現(xiàn)其具有鐵磁性行為。用剛果紅來評價Co/Co(OH)2納米復(fù)合物的吸附性能。實驗中我們發(fā)現(xiàn)150ppm的剛果紅能夠在10min內(nèi)完全被Co/Co(OH)2納米復(fù)合物從水溶液中移除，并且最大吸附量達到2058mg g1，這比之前所有報道過的值都要高。由于具有移除剛果紅所需的時間短，合成方法簡單、低成本以及零污染的優(yōu)點，Co/Co(OH)2可作為一種高效吸附劑從廢水中移除有機染料。 2.為了探討表面活性劑對Co/Co(OH)2納米復(fù)合物的成分與形貌的影響，陰離子表面活性劑檸檬酸鈉以及十二烷基苯磺酸鈉(SDBS)，聚合物表面活性劑聚乙烯吡咯烷酮(PVP)以及陽離子表面活性劑十六烷基三甲基溴化銨(CTAB)分別被應(yīng)用到實驗中。結(jié)果表明產(chǎn)物的形貌在某種程度上受到表面活性劑種類的影響。陰離子表面活性劑，像檸檬酸鈉和SDBS，有利于產(chǎn)物形成納米微球。聚合物和陽離子表面活性劑，像PVP和CTAB不能促進新的形貌的形成。此外，通過HRTEM圖片證實了最終產(chǎn)物仍為Co/Co(OH)2復(fù)合物，從而我們可以推斷出表面活性劑對產(chǎn)物的組成是沒有任何影響的。 3.利用一種簡單有效地溶劑熱法合成修飾的Fe3O4納米粒子(NPs)，并將這些納米粒子用于小鼠黑色素瘤的體內(nèi)核磁共振成像。在本實驗中，丙三醇由于具有無毒性和高粘性而被用作溶劑和還原劑，從而導(dǎo)致最終獲得的Fe3O4NPs具有分散性好和尺寸分布較窄的優(yōu)點。此外，基于檸檬酸鈉，L-天門冬酰胺以及PVP具有無/低毒性、水溶性和生物適應(yīng)性的優(yōu)點，這三種物質(zhì)將作為表面活性劑用來修飾Fe3O4NPs的表面，并且修飾過程是一步完成而非復(fù)雜的嫁接方法。另外，最終得到的修飾后的Fe3O4NPs水溶液被證實具有非常好的膠體穩(wěn)定性，在6個月內(nèi)液體中都不會出現(xiàn)絮凝物或者沉淀。然后，為了探究修飾后的Fe3O4NPs作為T2造影劑在核磁共振成像方面的生物應(yīng)用，檢測了NPs的T2加權(quán)成像和T2弛豫時間。結(jié)果表明，檸檬酸鈉修飾的Fe3O4NPs的r2弛豫率要高于檸檬酸鈉與PVP以及L-天門冬酰胺修飾的Fe3O4NPs。而且，對修飾后的NPs進行了體內(nèi)試驗，用于檢測植入小鼠內(nèi)的黑色素瘤。
[Abstract]:In this paper, the synthesis of new magnetic nanocomposites and their properties as adsorbent and nuclear magnetic resonance contrast agent were studied. The main contents and results are as follows: 1. Novel layered Co/Co (OH) _ 2 nanocomposites were synthesized by liquid reduction at room temperature for the first time, and the possible reaction mechanism and morphology development were proposed. The magnetic properties of Co/Co (OH) 2 were tested and found to be ferromagnetic. Congo red was used to evaluate the adsorption properties of Co/Co (OH) 2 nanocomposites. In our experiments, we found that the Congo red of 150ppm can be completely removed from the aqueous solution by Co/Co (OH) _ 2 nanocomposites in 10min, and the maximum adsorption capacity is up to 2058mg g _ 1, which is higher than all the previously reported values. Because of its advantages of short time to remove Congo red, simple synthesis method, low cost and zero pollution, Co/Co (OH) _ 2 can be used as an efficient adsorbent to remove organic dyes from wastewater. In order to investigate the effect of surfactants on the composition and morphology of Co/Co (OH) _ 2 nanocomposites, Anionic surfactant sodium citrate, sodium dodecyl benzene sulfonate (SDBS),) polymer surfactant polyvinylpyrrolidone (PVP) and cationic surfactant cetyltrimethylammonium bromide (CTAB) have been applied to the experiment. The results show that the morphology of the product is influenced to some extent by the type of surfactants. Anionic surfactants, such as sodium citrate and SDBS, facilitate the formation of nanospheres. Polymers and cationic surfactants, such as PVP and CTAB, do not promote the formation of new morphologies. In addition, the final product was confirmed to be Co/Co (OH) _ 2 complex by HRTEM images, so we can infer that the surfactant has no effect on the composition of the product. The modified Fe3O4 nanoparticles (NPs), were synthesized by a simple and effective solvothermal method and used in the in vivo nuclear magnetic resonance imaging of murine melanoma. In this experiment, propanetriol was used as solvent and reductant because of its nontoxicity and high viscosity, which led to the advantages of good dispersion and narrow size distribution of Fe3O4NPs. In addition, based on the advantages of sodium citrate, L-asparagine and PVP, which are non-toxic, water-soluble and bioadaptive, these three substances will be used as surfactants to modify the surface of Fe3O4NPs. And the modification process is a step-by-step rather than a complex grafting method. In addition, the final modified Fe3O4NPs aqueous solution was proved to have very good colloidal stability, no flocculation or precipitation occurred in the liquid for 6 months. Then, in order to explore the biological application of modified Fe3O4NPs as a T 2 contrast medium in MRI, the T 2 weighted imaging and T 2 relaxation time of NPs were measured. The results showed that the r2 relaxation rate of sodium citrate modified Fe3O4NPs was higher than that of sodium citrate and PVP and L-asparagine modified Fe3O4NPs.. Furthermore, the modified NPs was tested in vivo to detect melanoma implanted in mice.
【學(xué)位授予單位】：吉林大學(xué)
【學(xué)位級別】：碩士
【學(xué)位授予年份】：2015
【分類號】：TB383.1;TB33

【共引文獻】

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本文編號：2275871