【摘要】：DNA除了作為一種遺傳信息的載體分子之外,還可以通過(guò)折疊或組裝從而形成特定的二維和三維結(jié)構(gòu)。通過(guò)設(shè)計(jì)DNA分子的結(jié)構(gòu)并探索其與納米材料之間的相互作用的研究已經(jīng)引起了國(guó)內(nèi)外學(xué)術(shù)界的持續(xù)關(guān)注。DNA功能化的無(wú)機(jī)納米材料促進(jìn)了分析科學(xué)、生命科學(xué)以及環(huán)境科學(xué)的快速發(fā)展。本文將從疾病分子機(jī)制研究、疾病診斷和疾病治療三個(gè)角度出發(fā),探究面向生物醫(yī)學(xué)分析應(yīng)用的DNA分子功能化的無(wú)機(jī)納米材料的設(shè)計(jì)與組裝。除此之外,還對(duì)DNA功能化納米材料技術(shù)的發(fā)展前景進(jìn)行了展望。
[Abstract]:In addition to being a carrier of genetic information, DNA can be folded or assembled to form specific two-dimensional and three-dimensional structures. By designing the structure of DNA molecules and exploring the interaction between DNA molecules and nanomaterials, the research on the interaction between DNA molecules and nanomaterials has attracted the sustained attention of academic circles both at home and abroad, and has promoted the analytical science of inorganic nanomaterials. The rapid development of life science and environmental science. In this paper, we will explore the design and assembly of DNA molecular functionalized inorganic nanomaterials for biomedical analysis from the perspectives of disease molecular mechanism, disease diagnosis and disease treatment. In addition, the prospect of DNA functionalized nanomaterials is prospected.
【作者單位】： 武漢大學(xué)化學(xué)與分子科學(xué)學(xué)院;
【基金】：國(guó)家自然科學(xué)基金項(xiàng)目(51272186,21422105,21675120) 全國(guó)優(yōu)秀博士學(xué)位論文作者專項(xiàng)資金項(xiàng)目(201220) 湖北省自然科學(xué)基金項(xiàng)目(2015CFA032)資助
【分類號(hào)】：Q523;TB383.1
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本文編號(hào)：2224361