本文選題：氧化石墨烯 + BaGdF5��； 參考：《上海師范大學(xué)》2015年碩士論文

【摘要】：自從2004年氧化石墨烯(GO)被發(fā)現(xiàn)以來,GO逐漸成為了一種新興的納米材料。由于其優(yōu)越的光學(xué)、電學(xué)、熱學(xué)性能,GO在生物醫(yī)學(xué)和電化學(xué)領(lǐng)域有著廣泛的研究前景。由于GO較大的比表面積和表面豐富的官能團(tuán),氧化石墨烯可以作為載體,在GO表面負(fù)載具有特定功能的納米粒子或者大分子物質(zhì),應(yīng)用于生物醫(yī)學(xué)診斷治療領(lǐng)域。氧化石墨烯在近紅外區(qū)有較強的光學(xué)吸收,因此GO還可以作為光熱劑,用于癌癥的光熱治療研究,得到了理想的效果。本論文主要研究在氧化石墨烯表面修飾具有生物成像功能的Ba Gd F5納米粒子或者硒化鉍納米粒子,并用聚乙二醇(PEG)或者聚乙烯吡咯烷酮(PVP)對材料進(jìn)行表面修飾,使材料具有較好的生物相容性。制備的材料同時具有生物成像和光熱治療的功能。我們研究了材料在生物體內(nèi)的MR、CT成像和腫瘤光熱治療效果。本論文共分為四章。第一章綜述了氧化石墨烯的結(jié)構(gòu)、性質(zhì)、表面納米粒子修飾以及生物成像和光熱治療應(yīng)用。第二章研究了GO/Ba Gd F5/PEG納米材料的制備、光熱性質(zhì)及其在MR、CT成像和癌癥光熱治療方面的應(yīng)用。GO/Ba Gd F5/PEG納米材料通過溶劑熱法制備,Ba Gd F5納米粒子能夠均勻牢固地附著在GO表面。所得GO/Ba Gd F5/PEG納米材料具有較好的光熱性質(zhì)、光熱穩(wěn)定性、生物相容性和較低的生物毒性。GO/Ba Gd F5/PEG在細(xì)胞水平和荷瘤小鼠體內(nèi)都表現(xiàn)出較好的MR、CT成像效果,說明該材料可作為一種多模式生物成像造影劑。最后進(jìn)行了荷瘤小鼠體內(nèi)的腫瘤光熱治療實驗。經(jīng)尾靜脈注射的納米材料能夠在腫瘤部位富集,從而得到了很好的腫瘤光熱消融治療效果。GO/Ba Gd F5/PEG納米材料集MR、CT成像和癌癥光熱治療功能于一體,是一種在生物醫(yī)學(xué)上很有應(yīng)用前景的納米材料。第三章研究了GO/Bi2Se3/PVP納米材料在生物體內(nèi)的CT成像和腫瘤的光熱治療。在荷瘤小鼠的腫瘤部位直接注射該材料,然后對小鼠進(jìn)行CT成像掃描,得到了理想的腫瘤部位CT成像效果,說明該材料可作為CT成像造影劑,在CT成像方面具有潛在應(yīng)用前景。同時,研究了GO/Ba Gd F5/PEG材料對腫瘤的光熱消融效果,得到了理想的光熱治療效果。最后研究了該材料對荷瘤小鼠的毒性,實驗結(jié)果表明材料進(jìn)入小鼠體內(nèi)后具有很小的生物毒性。因此,GO/Bi2Se3/PVP納米材料可以作為生物體內(nèi)的CT成像造影劑和癌癥光熱治療劑。第四章對本論文得到的數(shù)據(jù)和結(jié)果進(jìn)行了總結(jié),最后對以GO為載體的納米材料在生物成像和癌癥光熱治療中的應(yīng)用進(jìn)行了前景展望。
[Abstract]:Since the discovery of graphene oxide (GOO) in 2004, go has gradually become a new nanometer material. Because of its excellent optical, electrical and thermal properties, go has a wide range of research prospects in biomedical and electrochemical fields. Because of its large specific surface area and abundant functional groups, graphene oxide can be used as a carrier to load nanoparticles or macromolecules with specific functions on the surface of go, which can be used in biomedical diagnosis and treatment. Graphene oxide has strong optical absorption in near infrared region, so go can also be used as photothermal agent for the study of photothermal treatment of cancer. In this paper, the surface modification of bagdF5 nanoparticles or bismuth selenide nanoparticles on graphene oxide surface was studied, and the surface modification was carried out with polyethylene glycol (PEG) or polyvinylpyrrolidone (PVP). The material has good biocompatibility. The prepared materials have the functions of biologic imaging and photothermal therapy. We studied the effect of MRCT imaging and photothermal therapy of tumor in vivo. This thesis is divided into four chapters. In chapter 1, the structure and properties of graphene oxide, surface nanoparticles modification and applications of biometric imaging and photothermal therapy are reviewed. In chapter 2, the preparation and photothermal properties of GO/Ba Gd F5/PEG nanomaterials and their applications in CT imaging and photothermal therapy of cancer. The obtained GO/Ba Gd F5/PEG nanomaterials showed good photothermal properties, photothermal stability, biocompatibility and low biotoxicity. It shows that this material can be used as a multi-mode biological imaging contrast agent. Finally, the photothermal therapy of tumor in mice bearing tumor was carried out. The nanomaterials injected through caudal vein can be enriched in the tumor site, so that the photothermal ablation effect of the tumor is very good. GO-P / Ba Gd F5/PEG nanomaterials are integrated with MRCT imaging and photothermal therapy for cancer. It is a kind of nanomaterials with great application prospect in biomedicine. In chapter 3, CT imaging and photothermal therapy of GO/Bi2Se3/PVP nanomaterials in vivo were studied. The material was injected directly into the tumor site of the tumor-bearing mice, and then CT imaging was performed on the mice. The result showed that the material could be used as a contrast agent for CT imaging and had a potential application prospect in CT imaging. At the same time, the photothermal ablation effect of GO/Ba Gd F5/PEG was studied. Finally, the toxicity of the material to tumor-bearing mice was studied. So GOP / Bi2Se3 / PVP nanomaterials can be used as CT imaging contrast agents and photothermic agents for cancer in vivo. In chapter 4, the data and results obtained in this paper are summarized. Finally, the prospect of the application of go nanomaterials in biological imaging and photothermal therapy of cancer is prospected.
【學(xué)位授予單位】：上海師范大學(xué)
【學(xué)位級別】：碩士
【學(xué)位授予年份】：2015
【分類號】：TB383.1;O613.71

【參考文獻(xiàn)】

相關(guān)碩士學(xué)位論文 前1條

1 曾波;氧化石墨烯/硒化物納米雜化材料的制備及其在光熱治療方面的應(yīng)用研究[D];上海師范大學(xué);2014年

，

本文編號：1936874