發(fā)布時(shí)間：2018-05-26 06:01

  本文選題：熒光成像 + 近紅外熒光��； 參考：《南京郵電大學(xué)》2017年碩士論文

【摘要】：熒光成像技術(shù)作為一種無創(chuàng)傷的技術(shù),已被廣泛用于跟蹤和了解生物體內(nèi)或體外復(fù)雜的環(huán)境,這在現(xiàn)代生命科學(xué)研究中都具有重要意義。與其他成像方式相比,熒光成像具有很高的時(shí)空分辨率。熒光成像的核心是熒光材料。因此,各種各樣具有高熒光強(qiáng)度,良好光穩(wěn)定性,高靈敏度,高信噪比,毒性低等特點(diǎn)的熒光材料已被設(shè)計(jì)和合成。本論文主要研究三種不同的共軛有機(jī)熒光材料在生物方面的應(yīng)用,包括近紅外熒光材料、固態(tài)熒光材料和熱激活延遲熒光材料。具體主要包括下面三方面:(1)通過幾種比較常見的合成方法制備了一種具有給體-受體-給體結(jié)構(gòu)的材料TAT-DPP-TAT。一方面,由于常見的近紅外的有機(jī)半導(dǎo)體熒光材料具有良好的光熱效應(yīng),所以將材料TAT-DPP-TAT用于光熱治療;另一方面,由于中心體吡咯并吡咯二酮在光動(dòng)力治療方面具有良好的作用,所以進(jìn)行了光動(dòng)力治療方面的測(cè)試,最終實(shí)現(xiàn)了材料的多應(yīng)用。(2)本章通過對(duì)傳統(tǒng)氟硼二吡咯材料結(jié)構(gòu)的改變,設(shè)計(jì)合成了一種在固態(tài)狀態(tài)下依然保持強(qiáng)熒光特性的材料。通過一系列的表征,研究其結(jié)構(gòu)與性能的關(guān)系。(3)通過Cadogan關(guān)環(huán)設(shè)計(jì)合成了幾種咔唑衍生物,然后通過一步法反應(yīng)合成了幾種具有給體-受體結(jié)構(gòu)的熱激活延遲熒光材料。通過對(duì)其性能的研究,主要包括其性能與結(jié)構(gòu)之間的關(guān)系,并在有機(jī)電致發(fā)光器件中得到應(yīng)用。
[Abstract]:As a non-invasive technique, fluorescence imaging technology has been widely used to track and understand the complex environment in vivo or in vitro, which is of great significance in modern life science research. Compared with other imaging methods, fluorescence imaging has high spatial and temporal resolution. The core of fluorescence imaging is fluorescent material. Therefore, various fluorescent materials with high fluorescence intensity, good light stability, high sensitivity, high signal-to-noise ratio and low toxicity have been designed and synthesized. In this paper, three kinds of conjugated organic fluorescent materials are studied in biological applications, including near infrared fluorescent materials, solid state fluorescent materials and thermal activated delayed fluorescence materials. A novel material with donor-receptor-donor structure, TAT-DPP-TAT, was prepared by several common synthetic methods. On the one hand, the common near infrared organic semiconductor fluorescent materials have good photothermal effect, so the material TAT-DPP-TAT is used for photothermal therapy; on the other hand, Since pyrrolidine pyrrolidone has a good role in photodynamic therapy, it has been tested in photodynamic therapy, and finally the multi-application of materials has been realized.) in this chapter, the structure of traditional fluoropyrrole dipyrrole materials has been changed by means of changing the structure of traditional fluoropyrrole dipyrrole materials. A material with strong fluorescence properties in solid state was designed and synthesized. Several carbazole derivatives were synthesized by Cadogan closed loop design, and then some heat-activated delayed fluorescence materials with donor-receptor structure were synthesized by one-step reaction. Through the study of its performance, including the relationship between its performance and structure, it has been applied in organic electroluminescent devices.
【學(xué)位授予單位】：南京郵電大學(xué)
【學(xué)位級(jí)別】：碩士
【學(xué)位授予年份】：2017
【分類號(hào)】：TB34

【參考文獻(xiàn)】

相關(guān)期刊論文 前1條

1 龔潔;沈清明;范曲立;黃維;;熒光有機(jī)小分子納米材料的合成及其應(yīng)用[J];化學(xué)進(jìn)展;2013年11期

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本文編號(hào)：1936199