本文選題：表面活性劑 + 離子液體微乳液　； 參考：《華南理工大學(xué)》2015年碩士論文

【摘要】：淀粉作為一種天然高分子材料,早期沒有被作為藥物載體原材料,主要是因?yàn)槠渌苄圆?不容易成球。以淀粉或其衍生物為原料制備淀粉微球,能夠使其作為藥物載體在生物體中緩慢降解釋放藥物,延長藥物達(dá)到體內(nèi)的作用時間,提高生物利用度。如果將淀粉微球制備成納米級,由于淀粉納米微球具有巨大的比表面積,顆粒具有較高的膠體穩(wěn)定性和吸附性能,能夠作為藥物載體材料在藥物傳輸系統(tǒng)中得到廣泛應(yīng)用。本文從離子液體微乳液的制備和性質(zhì)研究、基于離子液體微乳液體系淀粉納米微球的制備和表征及淀粉納米微球的載藥和釋藥性能等方面,對淀粉納米微球的制備及性質(zhì)進(jìn)行了系統(tǒng)研究,以期為淀粉納米微球的制備提供一條環(huán)保、高效的新方法,拓展淀粉納米微球在生物醫(yī)藥領(lǐng)域的應(yīng)用。分別制備了C16mim Br/正丁醇/環(huán)己烷/水和C16mim Br/正丁醇/環(huán)己烷/[Omim]Ac兩種不同類型離子液體微乳液,通過稀釋實(shí)驗(yàn)、動態(tài)光閃射技術(shù)、擬三元相圖、電導(dǎo)率等考察了微乳液的性質(zhì),證明了油包離子液體(W/O)和離子液體包水(IL/O)兩種微乳液體系的形成。分別以W/O和IL/O微乳液體系為反應(yīng)體系制備了淀粉納米微球。采用掃描電鏡(SEM)、動態(tài)光散射(DLS)技術(shù)、X-射線衍射(XRD)和紅外光譜(FTIR)對淀粉納米微球的結(jié)構(gòu)及性質(zhì)進(jìn)行了研究。SEM結(jié)果表明,淀粉納米微球?yàn)榍蛐晤w粒,顆粒尺寸較小;DLS結(jié)果顯示,淀粉納米微球的粒徑較小,粒徑分布范圍較窄;XRD圖譜表明,淀粉納米微球的結(jié)晶結(jié)構(gòu)消失,呈無定型結(jié)構(gòu);FTIR數(shù)據(jù)證明了淀粉分子間交聯(lián)鍵的形成。以淀粉納米微球?yàn)檩d體,亞甲基藍(lán)和鹽酸米托蒽醌為模型藥物,分別考察了時間、溫度和藥物濃度對淀粉納米微球載藥性能的影響。結(jié)果表明,隨著載藥時間的增加,淀粉納米微球的載藥量和包封率先增大后減小;隨著溫度的升高,淀粉納米微球的載藥量和包封率也同樣先增大后減小;隨著藥物濃度的增加,淀粉納米微球的載藥量逐漸增大,而包封率先增加后減小。載藥淀粉納米微球的釋藥過程主要包括兩個階段:快速釋放階段和緩慢釋放階段,淀粉納米微球表現(xiàn)出一定的緩釋性能。
[Abstract]:Starch, as a kind of natural polymer material, was not used as the raw material of drug carrier in the early stage, mainly because of its poor water solubility and difficult to be pelletized. Starch microspheres prepared from starch or its derivatives can be used as drug carriers to slowly degrade and release drugs in organism, prolong the time of drug reaching in vivo, and improve the bioavailability. If starch microspheres are prepared into nanometer scale, because of their huge specific surface area, high colloidal stability and adsorption performance, they can be widely used as drug carrier materials in drug transport system. In this paper, the preparation and properties of ionic liquid microemulsion, the preparation and characterization of starch nanospheres in ionic liquid microemulsion system, and the drug loading and drug release properties of starch nanoparticles were studied. The preparation and properties of starch nanospheres were systematically studied in order to provide a new method for the preparation of starch nanospheres and to expand the application of starch nanospheres in the field of biomedicine. Two different types of ionic liquid microemulsions, C16mim Br/ n-butanol / cyclohexane / water and C16mim Br/ n-butanol / cyclohexane / [Omim] ac, were prepared respectively. The properties of microemulsions were investigated by dilution experiment, dynamic flicker technique, pseudo-ternary phase diagram, conductivity, etc. The formation of two microemulsion systems, W / O and IL / O, has been proved. Starch nanoparticles were prepared from W / O and IL/O microemulsion systems. The structure and properties of starch nanospheres were studied by scanning electron microscope (SEM), dynamic light scattering (DLS) technique and FTIR (FTIR). The results of SEM showed that the starch nanoparticles were spherical and the particle size was smaller than that of DLS. The results of XRD showed that the crystalline structure of starch nanospheres disappeared, and the FTIR data showed that the formation of cross-linking bonds between starch molecules was proved by FTIR data. The effects of time, temperature and drug concentration on the drug delivery properties of starch nanospheres were investigated by using methylene blue and mitoxantrone hydrochloride as model drugs. The results showed that the drug loading and encapsulation rate of starch nanoparticles increased first and then decreased with the increase of drug loading time, and the drug loading and encapsulation efficiency of starch nanoparticles increased first and then decreased with the increase of temperature. With the increase of drug concentration, the drug loading of starch nanoparticles increased gradually, while the encapsulation increased first and then decreased. The drug release process of drug loaded starch nanoparticles mainly includes two stages: rapid release phase and slow release phase. Starch nanoparticles show a certain sustained release performance.
【學(xué)位授予單位】：華南理工大學(xué)
【學(xué)位級別】：碩士
【學(xué)位授予年份】：2015
【分類號】：TS236.9;TB383.1

【參考文獻(xiàn)】

相關(guān)期刊論文 前10條

1 張英鋒,李長江,包富山,張永安;離子液體的分類、合成與應(yīng)用[J];化學(xué)教育;2005年02期

2 任強(qiáng),武進(jìn),張軍,何嘉松,過梅麗;1-烯丙基,3-甲基咪唑室溫離子液體的合成及其對纖維素溶解性能的初步研究[J];高分子學(xué)報;2003年03期

3 周巧萍;武進(jìn);張軍;何嘉松;孫志杰;張佐光;;高直鏈淀粉乙酸酯的均相合成及其靜電紡絲[J];高分子學(xué)報;2007年07期

4 王媛媛;孫輝;戴立益;;室溫離子液體在聚合反應(yīng)中的應(yīng)用[J];高分子通報;2006年05期

5 馬云鵬;鄭升;;抗腫瘤藥米托蒽醌[J];國外醫(yī)藥.合成藥.生化藥.制劑分冊;1986年06期

6 徐霞,劉萃紅,許世華,李淑榮,許培榮,楊青梅,晁平,王麗君;順鉑-可降解淀粉微球家兔動脈栓塞藥動學(xué)研究[J];海峽藥學(xué);2001年01期

7 馬素德,郭焱,李仲謹(jǐn),邱維,曹直;淀粉微球的用途及發(fā)展建議[J];化工新型材料;2003年10期

8 詹國平,黃可龍,張法旺;陰離子型淀粉微球的制備研究[J];化工新型材料;2005年06期

9 何鳴元,戴立益;離子液體與綠色化學(xué)[J];化學(xué)教學(xué);2002年06期

10 陳宗淇，郭榮;微乳液的微觀結(jié)構(gòu)[J];化學(xué)通報;1994年02期

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