本文選題：羥基磷灰石　切入點(diǎn)：殼聚糖　出處：《東華大學(xué)》2016年碩士論文

【摘要】：羥基磷灰石(HAP)復(fù)合材料是利用材料復(fù)合技術(shù),在HAP中加入第二相或者多相組分制備而得,既具備HAP的生物相容性和生物活性,同時(shí)有機(jī)大分子優(yōu)良的加工性能和韌性也得到了利用。本研究分別采用具有生物相容性的殼聚糖(CS)、羧甲基纖維素鈉(CMC)和β-環(huán)糊精(β-CD)作為基質(zhì),加入合成HAP所需要的鈣源和磷源,利用大分子的結(jié)構(gòu)差異,誘導(dǎo)HAP在基質(zhì)上的生長(zhǎng),原位合成有機(jī)分子/羥基磷灰石復(fù)合材料。通過對(duì)復(fù)合材料的性能進(jìn)行表征,分析不同條件下合成的HAP復(fù)合材料的結(jié)構(gòu)組成和形貌,并探討HAP與不同有機(jī)大分子之間的復(fù)合機(jī)理。首先利用原位合成法制備CS/HAP復(fù)合膜,借助傅里葉變換紅外光譜(FT-IR)、熱重分析(TG)、掃描電鏡(SEM)對(duì)CS/HAP復(fù)合膜進(jìn)行表征,并對(duì)復(fù)合膜的吸水性、尺寸穩(wěn)定性、力學(xué)性能、潤(rùn)濕性進(jìn)行了測(cè)試分析。結(jié)果表明CS的-NH2和HAP的-OH參與了CS和HAP之間的復(fù)合;無機(jī)HAP在CS有機(jī)基質(zhì)中均勻分布,CS/HAP復(fù)合膜具有層狀結(jié)構(gòu);CS/HAP復(fù)合膜的吸水率低于CS膜,使得復(fù)合膜在濕態(tài)條件下的尺寸穩(wěn)定性提高;CS/HAP復(fù)合膜的拉伸強(qiáng)度高于CS膜,這是由于CS/HAP復(fù)合膜含有層狀結(jié)構(gòu),當(dāng)受到外力作用時(shí),通過CS中-NH2與HAP中-OH的相互作用,可以實(shí)現(xiàn)力的傳遞;同時(shí)CS/HAP復(fù)合膜的熱穩(wěn)定性也得到了一定的提高。采用與制備CS/HAP復(fù)合膜類似的方法合成CMC/HAP復(fù)合膜,利用FT-IR、TG和SEM對(duì)CMC/HAP復(fù)合膜進(jìn)行表征,對(duì)復(fù)合膜的吸水性、尺寸穩(wěn)定性、力學(xué)性能、潤(rùn)濕性進(jìn)行了測(cè)試分析。結(jié)果表明CMC的-COO-和HAP的-OH參與了CMC和HAP的復(fù)合;加入HAP后可以改善CMC/HAP復(fù)合膜的吸濕性和尺寸穩(wěn)定性;CMC/HAP復(fù)合膜的拉伸強(qiáng)度低于CMC膜;同時(shí)CMC/HAP復(fù)合膜的熱穩(wěn)定性得到了一定的提高。利用原位合成法分別在20℃和90℃條件下合成β-CD/HAP復(fù)合物,借助FT-IR、TG和SEM對(duì)反應(yīng)產(chǎn)物進(jìn)行了表征,研究溫度和β-CD濃度對(duì)產(chǎn)物的組成、熱穩(wěn)定性、形貌等的影響。結(jié)果表明在堿性條件下,β-CD中C6位置上的-OH首先結(jié)合Ca2+,形成HAP的成核位點(diǎn),然后HAP沿著β-CD自組裝的分子長(zhǎng)鏈生長(zhǎng),隨著β-CD濃度的增大,制備的產(chǎn)物由最初的無規(guī)團(tuán)聚逐漸變成針狀、棒狀結(jié)構(gòu)。溫度對(duì)復(fù)合物的形成也有一定的影響,低溫條件下制備的復(fù)合物中含有較多的碳酸鹽和磷酸鹽副產(chǎn)物,提高反應(yīng)溫度可以減少副產(chǎn)物的生成,改善HAP在β-CD中分布的均勻性。
[Abstract]:Hydroxyapatite / apatite (HAP) composite was prepared by adding the second phase or multiphase component into HAP by using the composite technology of materials. It has the biocompatibility and bioactivity of HAP. At the same time, the excellent processability and toughness of organic macromolecules were also utilized. In this study, chitosan (CSC), carboxymethyl cellulose (CMCs) and 尾 -cyclodextrin (尾 -CD) were used as the substrates for the synthesis of HAP. The structure difference of macromolecules was used to induce the growth of HAP on the matrix. The organic molecule / hydroxyapatite composites were synthesized in situ. The properties of the composites were characterized. The structure and morphology of HAP composites synthesized under different conditions were analyzed, and the composite mechanism between HAP and different organic macromolecules was discussed. Firstly, CS/HAP composite films were prepared by in situ synthesis. The CS/HAP composite films were characterized by Fourier transform infrared spectroscopy (FTIR), thermogravimetric analysis (TG) and scanning electron microscopy (SEM). The wettability of CS / HAP composite membrane was tested and analyzed. The results showed that CS / HAP composite film had a lamellar structure and the water absorption of CS / HAP composite membrane was lower than that of CS / HAP composite membrane, and the inorganic HAP was uniformly distributed in CS / HAP composite membrane. The results showed that the water absorption rate of CS / HAP composite membrane was lower than that of CS / HAP composite membrane. The tensile strength of CS- / HAP composite film is higher than that of CS / HAP composite film under wet condition, which is due to the lamellar structure of CS/HAP composite membrane. When the composite membrane is subjected to external force, the interaction between -NH _ 2 in CS and -OH in HAP can be obtained by the interaction of -NH _ 2 in CS and -OH in HAP. At the same time, the thermal stability of the CS/HAP composite membrane was also improved. The CMC/HAP composite membrane was synthesized by using the method similar to the preparation of the CS/HAP composite membrane. The CMC/HAP composite membrane was characterized by FT-IRTG and SEM, and the water absorbency of the composite membrane was characterized by FT-IRTG and SEM. Dimensional stability, mechanical properties and wettability were tested and analyzed. The results showed that CMC and HAP -OH were involved in the combination of CMC and HAP. Adding HAP can improve the moisture absorption and dimensional stability of CMC/HAP composite membrane. The tensile strength of CMC / HAP composite membrane is lower than that of CMC film. At the same time, the thermal stability of CMC/HAP composite membrane was improved. 尾 -CD / HAP complex was synthesized by in-situ synthesis at 20 鈩，

本文編號(hào)：1670701