本文選題：納米材料　切入點(diǎn)：納米閥門(mén)　出處：《北京科技大學(xué)》2017年博士論文　論文類(lèi)型：學(xué)位論文

【摘要】：隨著納米技術(shù)的蓬勃發(fā)展,實(shí)現(xiàn)宏觀尺度機(jī)械的微小型化擁有十分廣闊的前景。已經(jīng)有越來(lái)越多的化學(xué)家與工程師在分子水平和超分子水平上開(kāi)發(fā)出了納米尺度的機(jī)器。納米閥門(mén),是一種可以控制分子進(jìn)出納米孔的納米尺度的機(jī)器。納米閥門(mén)在分離、化學(xué)和生物傳感器、化學(xué)存儲(chǔ)、精準(zhǔn)醫(yī)療等領(lǐng)域擁有廣闊的應(yīng)用前景。本論文設(shè)計(jì)了一種基于親疏水轉(zhuǎn)換的無(wú)封堵納米閥門(mén),并且通過(guò)引入光子晶體賦予其傳感能力。主要內(nèi)容如下:1、我們以二氧化硅為載體,設(shè)計(jì)了一種基于親疏水轉(zhuǎn)換的電刺激響應(yīng)無(wú)封堵控制釋放體系,實(shí)現(xiàn)了無(wú)封堵納米閥門(mén)的初步構(gòu)建。利用共縮聚法,將具有親疏水轉(zhuǎn)換性質(zhì)的功能分子修飾在介孔孔道內(nèi)側(cè),修飾后的孔道可以通過(guò)改變自身對(duì)水的浸潤(rùn)性來(lái)控制藥物的釋放行為。這種藥物控釋體系不同于對(duì)依賴(lài)于實(shí)體封堵的控釋體系,制備和負(fù)載藥物過(guò)程簡(jiǎn)單而高效,并且無(wú)由封堵物帶來(lái)的各種毒副作用,具有很強(qiáng)的實(shí)際應(yīng)用潛力。2、我們基于介孔反Opal光子晶體,通過(guò)共縮聚法修飾苯胺基團(tuán)到介孔反Opal光子晶體結(jié)構(gòu)中,制備了 pH響應(yīng)的無(wú)封堵納米閥門(mén),實(shí)現(xiàn)了無(wú)封堵納米閥門(mén)的自傳感。苯胺基團(tuán)具有pH響應(yīng)的親疏水轉(zhuǎn)換特性,在pH為中性條件下,處于疏水狀態(tài),閥門(mén)關(guān)閉,而此時(shí)光子晶體薄膜顯示為綠色。而在pH為酸性環(huán)境下,苯胺變?yōu)橛H水狀態(tài),閥門(mén)開(kāi)啟,而此時(shí)光子晶體薄膜隨著溶液的侵入程度顯示為黃色到紅色。該閥門(mén)不僅實(shí)現(xiàn)了無(wú)封堵控制,而且實(shí)現(xiàn)了閥門(mén)狀態(tài)的無(wú)指示劑傳感,為光子晶體傳感器和納米閥門(mén)傳感提供了新的思路和前景。3、我們基于介孔反Opal光子晶體,通過(guò)后修飾法將二茂鐵功能基團(tuán)修飾到介孔反Opal光子晶體結(jié)構(gòu)中,制備了電響應(yīng)的無(wú)封堵納米閥門(mén),并且將其用于控制釋放的實(shí)時(shí)傳感。二茂鐵具有電場(chǎng)響應(yīng)的親疏水轉(zhuǎn)換特性,在未加電刺激時(shí)處于疏水狀態(tài),閥門(mén)關(guān)閉,藥物封裝在介孔反Opal光子晶體內(nèi)。當(dāng)施加電刺激后,二茂鐵發(fā)生電氧化轉(zhuǎn)變?yōu)橛H水態(tài),閥門(mén)開(kāi)啟,溶液侵入導(dǎo)致藥物釋放,同時(shí)光子晶體顏色發(fā)生改變。該反Opal光子晶體控制釋放系統(tǒng)不僅實(shí)現(xiàn)了無(wú)封堵控制釋放,更實(shí)現(xiàn)了控制釋放狀態(tài)的實(shí)時(shí)監(jiān)測(cè),為控制釋放和及其傳感提供了新的思路和前景。
[Abstract]:With the rapid development of nanotechnology, Microminiaturization of macro-scale machinery has a very broad prospect. More and more chemists and engineers have developed nanoscale machines, nanovalves, at both molecular and supramolecular levels. Is a nano-scale machine that controls the flow of molecules into and out of nanopores. Nanovalves are in separation, chemical and biological sensors, chemical storage, In this paper, a kind of unplugged nano-valve based on hydrophilic conversion is designed, and the sensing ability is given by introducing photonic crystal. The main contents are as follows: 1, we use silica as carrier. Based on hydrophilic conversion, an electrically stimulated unplugged controlled release system was designed to realize the preliminary construction of unplugged nano-valves. The functional molecules with hydrophilic conversion properties were modified on the inner side of mesoporous channels by co-condensation. The modified pore can control the release behavior of the drug by changing its own wettability to water. This drug controlled release system is different from the controlled release system which depends on the solid plugging. The preparation and loading of the drug is simple and efficient. Moreover, there are no toxic and side effects caused by plugging materials, so it has strong practical application potential. Based on mesoporous inverse Opal photonic crystal, we modify aniline group into mesoporous reverse Opal photonic crystal structure by co-condensation method. An unplugged nano-valve with pH response was prepared to realize the autobiographical sensation of the valve. The aniline group has the hydrophilic conversion characteristic of pH response, which is in the hydrophobic state under the condition of neutral pH, and the valve is closed. At this point, the photonic crystal film is shown to be green. When pH is acidic, aniline becomes hydrophilic and the valve opens. At this time, the photonic crystal film is shown to be yellow to red with the invasion degree of the solution. The valve not only has no plugging control, but also realizes the non-indicator sensing of the valve state. It provides a new idea and prospect for photonic crystal sensor and nano-valve sensor. Based on mesoporous inverse Opal photonic crystal, we modify ferrocene functional group into mesoporous inverse Opal photonic crystal structure by post modification method. An electrically responsive unplugged nano-valve was prepared and used for real-time sensing of controlled release. Ferrocene has hydrophilic conversion characteristics of electric field response and is in a hydrophobic state without electrical stimulation and the valve is closed. The drug is encapsulated in a mesoporous inverse Opal photonic crystal. After electrical stimulation, ferrocene is electrooxidized to a hydrophilic state, the valve opens, and the solution invades causing the drug to be released. At the same time, the color of photonic crystal is changed. The control release system of anti-#en0# photonic crystal not only realizes the controlled release without plugging, but also realizes the real-time monitoring of the state of controlled release, which provides a new idea and prospect for the control release and its sensing.
【學(xué)位授予單位】：北京科技大學(xué)
【學(xué)位級(jí)別】：博士
【學(xué)位授予年份】：2017
【分類(lèi)號(hào)】：TB383.1;O734

【參考文獻(xiàn)】

相關(guān)期刊論文 前1條

1 Yu-Jie Chang;Xi-Zhen Liu;Qing Zhao;Xiao-Hai Yang;Ke-Min Wang;Qing Wang;Min Lin;Meng Yang;;P(VPBA-DMAEA) as a pH-sensitive nanovalve for mesoporous silica nanoparticles based controlled release[J];Chinese Chemical Letters;2015年10期

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本文編號(hào)：1631115