本文選題：納米材料　切入點：納米閥門　出處：《北京科技大學》2017年博士論文　論文類型：學位論文

【摘要】：隨著納米技術的蓬勃發(fā)展,實現(xiàn)宏觀尺度機械的微小型化擁有十分廣闊的前景。已經(jīng)有越來越多的化學家與工程師在分子水平和超分子水平上開發(fā)出了納米尺度的機器。納米閥門,是一種可以控制分子進出納米孔的納米尺度的機器。納米閥門在分離、化學和生物傳感器、化學存儲、精準醫(yī)療等領域擁有廣闊的應用前景。本論文設計了一種基于親疏水轉換的無封堵納米閥門,并且通過引入光子晶體賦予其傳感能力。主要內(nèi)容如下:1、我們以二氧化硅為載體,設計了一種基于親疏水轉換的電刺激響應無封堵控制釋放體系,實現(xiàn)了無封堵納米閥門的初步構建。利用共縮聚法,將具有親疏水轉換性質(zhì)的功能分子修飾在介孔孔道內(nèi)側,修飾后的孔道可以通過改變自身對水的浸潤性來控制藥物的釋放行為。這種藥物控釋體系不同于對依賴于實體封堵的控釋體系,制備和負載藥物過程簡單而高效,并且無由封堵物帶來的各種毒副作用,具有很強的實際應用潛力。2、我們基于介孔反Opal光子晶體,通過共縮聚法修飾苯胺基團到介孔反Opal光子晶體結構中,制備了 pH響應的無封堵納米閥門,實現(xiàn)了無封堵納米閥門的自傳感。苯胺基團具有pH響應的親疏水轉換特性,在pH為中性條件下,處于疏水狀態(tài),閥門關閉,而此時光子晶體薄膜顯示為綠色。而在pH為酸性環(huán)境下,苯胺變?yōu)橛H水狀態(tài),閥門開啟,而此時光子晶體薄膜隨著溶液的侵入程度顯示為黃色到紅色。該閥門不僅實現(xiàn)了無封堵控制,而且實現(xiàn)了閥門狀態(tài)的無指示劑傳感,為光子晶體傳感器和納米閥門傳感提供了新的思路和前景。3、我們基于介孔反Opal光子晶體,通過后修飾法將二茂鐵功能基團修飾到介孔反Opal光子晶體結構中,制備了電響應的無封堵納米閥門,并且將其用于控制釋放的實時傳感。二茂鐵具有電場響應的親疏水轉換特性,在未加電刺激時處于疏水狀態(tài),閥門關閉,藥物封裝在介孔反Opal光子晶體內(nèi)。當施加電刺激后,二茂鐵發(fā)生電氧化轉變?yōu)橛H水態(tài),閥門開啟,溶液侵入導致藥物釋放,同時光子晶體顏色發(fā)生改變。該反Opal光子晶體控制釋放系統(tǒng)不僅實現(xiàn)了無封堵控制釋放,更實現(xiàn)了控制釋放狀態(tài)的實時監(jiān)測,為控制釋放和及其傳感提供了新的思路和前景。
[Abstract]:With the rapid development of nanotechnology, Microminiaturization of macro-scale machinery has a very broad prospect. More and more chemists and engineers have developed nanoscale machines, nanovalves, at both molecular and supramolecular levels. Is a nano-scale machine that controls the flow of molecules into and out of nanopores. Nanovalves are in separation, chemical and biological sensors, chemical storage, In this paper, a kind of unplugged nano-valve based on hydrophilic conversion is designed, and the sensing ability is given by introducing photonic crystal. The main contents are as follows: 1, we use silica as carrier. Based on hydrophilic conversion, an electrically stimulated unplugged controlled release system was designed to realize the preliminary construction of unplugged nano-valves. The functional molecules with hydrophilic conversion properties were modified on the inner side of mesoporous channels by co-condensation. The modified pore can control the release behavior of the drug by changing its own wettability to water. This drug controlled release system is different from the controlled release system which depends on the solid plugging. The preparation and loading of the drug is simple and efficient. Moreover, there are no toxic and side effects caused by plugging materials, so it has strong practical application potential. Based on mesoporous inverse Opal photonic crystal, we modify aniline group into mesoporous reverse Opal photonic crystal structure by co-condensation method. An unplugged nano-valve with pH response was prepared to realize the autobiographical sensation of the valve. The aniline group has the hydrophilic conversion characteristic of pH response, which is in the hydrophobic state under the condition of neutral pH, and the valve is closed. At this point, the photonic crystal film is shown to be green. When pH is acidic, aniline becomes hydrophilic and the valve opens. At this time, the photonic crystal film is shown to be yellow to red with the invasion degree of the solution. The valve not only has no plugging control, but also realizes the non-indicator sensing of the valve state. It provides a new idea and prospect for photonic crystal sensor and nano-valve sensor. Based on mesoporous inverse Opal photonic crystal, we modify ferrocene functional group into mesoporous inverse Opal photonic crystal structure by post modification method. An electrically responsive unplugged nano-valve was prepared and used for real-time sensing of controlled release. Ferrocene has hydrophilic conversion characteristics of electric field response and is in a hydrophobic state without electrical stimulation and the valve is closed. The drug is encapsulated in a mesoporous inverse Opal photonic crystal. After electrical stimulation, ferrocene is electrooxidized to a hydrophilic state, the valve opens, and the solution invades causing the drug to be released. At the same time, the color of photonic crystal is changed. The control release system of anti-#en0# photonic crystal not only realizes the controlled release without plugging, but also realizes the real-time monitoring of the state of controlled release, which provides a new idea and prospect for the control release and its sensing.
【學位授予單位】：北京科技大學
【學位級別】：博士
【學位授予年份】：2017
【分類號】：TB383.1;O734

【參考文獻】

相關期刊論文 前1條

1 Yu-Jie Chang;Xi-Zhen Liu;Qing Zhao;Xiao-Hai Yang;Ke-Min Wang;Qing Wang;Min Lin;Meng Yang;;P(VPBA-DMAEA) as a pH-sensitive nanovalve for mesoporous silica nanoparticles based controlled release[J];Chinese Chemical Letters;2015年10期

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本文編號：1631115