本文關(guān)鍵詞： 超疏水 表面增強拉曼散射 高靈敏 化學方法　出處：《吉林大學》2017年碩士論文　論文類型：學位論文

【摘要】：表面增強拉曼散射(Surface Enhanced Raman Scattering,SERS)是一種杰出的分析方法,對于稀釋到單分子濃度的溶液具有靈敏響應。自從1974年被發(fā)現(xiàn)以來,一直受到學者們的高度關(guān)注。由于其具有分子指紋識別能力,SERS被廣泛應用于化學分析、環(huán)境監(jiān)測、生物傳感等領(lǐng)域。由貴金屬納米結(jié)構(gòu)構(gòu)筑的SERS基底可以提供強的局域電磁場(Hot Spot),當分子吸附在強電磁場中時,分子的拉曼散射信號被顯著提高。得益于近年來微納米加工技術(shù)的發(fā)展,諸多新奇的金屬納米結(jié)構(gòu)被設(shè)計出來以便于獲得更高的拉曼增強因子。盡管這些納米結(jié)構(gòu)具有較高的增強因子,但是依然很難達到單分子檢測水平。同時納米結(jié)構(gòu)的加工與制備依然需要高能耗的加工制備手段,這在成本上限制了拉曼檢測在現(xiàn)實生活中的應用。本文著眼于如何利用簡單的加工制備手段制備出具有較高檢測靈敏度的拉曼基底,并且在降低檢測成本和提高檢測靈敏度方面做出討論。本文圍繞發(fā)展用簡單方法制備高靈敏度的拉曼檢測基底,以及如何提高拉曼檢測靈敏度展開工作,主要包括以下兩個部分:一、利用紙作為基底,通過涂料噴涂技術(shù)實現(xiàn)低成本高產(chǎn)量超疏水基底的制備,同時利用銀納米粒子和待測物分子在超疏水基底上的濃縮富集,將待測物分布在銀納米粒子之間,利用銀納米粒子的共振耦合效應進行拉曼檢測。二、利用基底的疏水性在基底上滴加水滴,利用水滴對光的折射效果對拉曼散射光進行收集,以提高拉曼檢測的靈敏度。
[Abstract]:Surface enhanced Raman scattering (SERS) is an excellent analytical method. Since it was discovered in 1974, it has been highly concerned by scholars because of its ability to identify molecular fingerprints. SERS is widely used in chemical analysis, environmental monitoring, biosensor and other fields. The SERS substrate based on noble metal nanostructures can provide a strong local electromagnetic field hot spot. When molecules are adsorbed in strong electromagnetic fields, the Raman scattering signals of molecules are greatly improved, which is due to the development of microfabrication technology in recent years. A number of novel metal nanostructures have been designed to facilitate the acquisition of higher Raman enhancement factors, although these nanostructures have higher enhancement factors. However, it is still difficult to achieve the level of single molecule detection. Meanwhile, the processing and preparation of nanostructures still need high-energy processing and preparation methods. This cost limits the application of Raman detection in real life. In this paper, we focus on the preparation of Raman substrate with high detection sensitivity by using simple fabrication methods. In this paper, we focus on the development of simple methods to prepare high sensitivity Raman detection substrate, and how to improve the sensitivity of Raman detection work. It mainly includes the following two parts: first, using paper as substrate, the preparation of super-hydrophobic substrate with low cost and high yield can be realized by coating spraying technology. At the same time, using the enrichment of silver nanoparticles and the molecules to be tested on superhydrophobic substrates, the samples were distributed among silver nanoparticles, and the resonance coupling effect of silver nanoparticles was used for Raman detection. 2. The hydrophobicity of the substrate is used to add water drop on the substrate and the light refraction effect of the water drop is used to collect the Raman scattering light in order to improve the sensitivity of Raman detection.
【學位授予單位】：吉林大學
【學位級別】：碩士
【學位授予年份】：2017
【分類號】：TB306;O657.37

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