發(fā)布時(shí)間：2018-01-11 12:42

  本文關(guān)鍵詞：烷硫醇包覆金納米棒的超瑞利散射研究　出處：《武漢大學(xué)》2017年碩士論文　論文類(lèi)型：學(xué)位論文

  更多相關(guān)文章： 金納米棒 硫醇衍生物包覆層 超瑞利散射 一階超極化率 去極化率 分子聚集

【摘要】：金納米棒具有獨(dú)特的光學(xué)性質(zhì)以及很好的生物相容性,其在光學(xué)傳感、生物分子成像、醫(yī)學(xué)診斷和腫瘤治療等領(lǐng)域都有很廣闊的應(yīng)用前景。但是金納米棒的高比表面能又使其不夠穩(wěn)定,易于發(fā)生集聚。為了有效利用金納米棒,須對(duì)其表面進(jìn)行修飾與包覆。好的包覆層既可以增強(qiáng)其穩(wěn)定性,又能增加新功能,其中的硫醇衍生物包覆層可以與金納米微粒形成穩(wěn)定的金-硫配位鍵,在生物檢測(cè)中具有很高的靈敏度,因而被廣泛研究。超瑞利散射(HRS)技術(shù)是研究材料二階非線(xiàn)性性質(zhì)的常用方法之一,它廣泛地應(yīng)用于液體中納米微粒和分子的檢測(cè)。該論文根據(jù)HRS理論,站在非線(xiàn)性光學(xué)的視角對(duì)烷硫醇包覆的金納米棒展開(kāi)研究。該工作基于銀離子輔助種子生長(zhǎng)法分別合成了具有十六烷基三甲基溴化銨(CTAB)、十二烷基硫醇和十八烷基硫醇包覆層的金納米棒,并采用HRS測(cè)試技術(shù)以及透射電鏡、紫外-可見(jiàn)吸收光譜對(duì)它們的特性進(jìn)行了研究;該工作還模擬了棒狀分子中心對(duì)稱(chēng)型集聚的超瑞利散射響應(yīng),對(duì)實(shí)驗(yàn)結(jié)果進(jìn)行了對(duì)比分析。結(jié)果表明CTAB包覆層增強(qiáng)了一階超極化率,而烷硫醇包覆層削弱了一階超極化率;相對(duì)于短鏈烷基的烷硫醇包覆層,具有長(zhǎng)鏈烷基的烷硫醇包覆層能更有效的地阻止棒粒的聚集,但是具有不同長(zhǎng)度烷基鏈的烷硫醇包覆層對(duì)一階超級(jí)化率的削弱程度卻是相同的。通過(guò)分析偏振超瑞利散射的強(qiáng)度響應(yīng)可以計(jì)算出"去極化率"和"權(quán)重參數(shù)",實(shí)驗(yàn)和模擬結(jié)果都表明對(duì)于尺寸較小(遠(yuǎn)小于入射光波長(zhǎng)的十分之一)且表面存在缺陷的球形納米微粒或者是長(zhǎng)鏈分子,電偶極子作用占主導(dǎo),去極化率的值約為0.2,權(quán)重參數(shù)的值約為0;當(dāng)納米微粒的表面缺陷得到補(bǔ)償或者微粒尺寸增加,電四(多)極子作用的比重增加,去極化率和權(quán)重參數(shù)的值都將增大。超瑞利散射方法在探查納米顆粒的表面缺陷和分子的聚集行為方面有很高的靈敏度。
[Abstract]:Gold nanorods have unique optical properties and good biocompatibility, in optical sensing, molecular imaging, medical diagnosis and treatment of cancer and other fields have a very broad application prospect. But the high surface area of gold nanorods can make it is not stable enough, prone to agglomeration. In order to make effective use of gold nanorods, must be carried out modification and coating on its surface. The coating layer can enhance its stability, but also can increase the new function, the thiol derivative coating layer can form stable gold sulfur coordination bonds with gold nanoparticles, has very high sensitivity in biological detection, so it has been widely studied. The hyper Rayleigh scattering (HRS) technology is one of the commonly used methods of materials of two order nonlinear properties, it is widely used in the detection of liquid nano particles and molecules. On the basis of HRS theory, nonlinear optical standing in the angle of view to the alkythio Study on alcohol coated gold nanorods. Silver ion assisted seed growth method based on the work were synthesized with sixteen alkyl three methyl bromide (CTAB), twelve and eighteen alkyl thiol alkyl thiol coated gold nanorods, and using HRS test and transmission electron microscopy, UV Vis absorption spectra of their properties studied the work; simulated the hyper Rayleigh scattering response center symmetric compact molecules, the experimental results were analyzed. The results show that the CTAB coating enhanced hyperpolarability, while the alkanethiolate coated layer weakens hyperpolarability; compared with short chain alkyl alkanethiolate coated layer, with long alkyl chain alkanethiolate coated layer can effectively prevent particle rod aggregation, but with different length of alkyl chain alkanethiolate coated layer on the first hyperpolarizability of the weakening degree is the same By the analysis of polarization hyper Rayleigh scattering intensity response can be calculated "depolarization ratio" and "weight parameters, experimental and simulation results show that for small size (much less than the wavelength of the incident light 1/10) spherical nanoparticles and surface defects or long chain molecules, the electric dipole effect dominates, to the polarization rate is about 0.2, the value of parameters is about 0; when the surface defects of nanometer particle are compensated or particle size increases, four (multiple) pole effect proportion increase, the depolarization ratio and weight parameter value will increase. The hyper Rayleigh scattering method has very high sensitivity in the aggregation behavior of surface defects and molecular probe nano particles.

【學(xué)位授予單位】：武漢大學(xué)
【學(xué)位級(jí)別】：碩士
【學(xué)位授予年份】：2017
【分類(lèi)號(hào)】：O614.123;TB383.1

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