本文選題：二甲基乙酰胺 + 甲基乙酰胺　； 參考：《環(huán)境與職業(yè)醫(yī)學(xué)》2017年11期

【摘要】：[目的]研究作業(yè)場所二甲基乙酰胺(DMAC)濃度與職業(yè)人群生物監(jiān)測指標水平的關(guān)系,進一步探討DMAC的職業(yè)接觸生物限值。[方法]對生產(chǎn)4,4’-二氨基二苯醚的某企業(yè)進行勞動衛(wèi)生學(xué)調(diào)查,連續(xù)采集32名DMAC接觸工人工作周第1天、第2天及第5天的班前和班末尿樣,采用氣相色譜法測定尿中甲基乙酰胺(NMAC)水平;同時應(yīng)用個體采樣器收集工作日的作業(yè)場所空氣中DMAC,并進行濃度測定。通過多元回歸分析班末尿中NMAC水平與個體接觸量、工齡、年齡的相關(guān)性;同時收集職業(yè)健康監(jiān)護資料,分析DMAC接觸濃度與健康效應(yīng)的關(guān)系。[結(jié)果]車間內(nèi)空氣中DMAC 8 h時間加權(quán)平均濃度(8 h-TWA)為(121.32±164.31)mg/m~3(1.30~818.20 mg/m~3),其中26份樣品DMAC濃度超出國家職業(yè)衛(wèi)生標準(20 mg/m~3),超標率81.25%。不同工作日的班前及班末尿中NMAC水平并無明顯差異(均P0.05)。多元回歸結(jié)果顯示,DMAC接觸工人班末尿中NMAC水平與空氣中DMAC個體暴露濃度呈正相關(guān),lgρ_(NMAC)(mg/g)=0.303+0.677lgω_(DMAC)(mg/m~3)(R~2=0.725,F=63.18,P0.001)。[結(jié)論]研究發(fā)現(xiàn)尿中NAMC并無蓄積現(xiàn)象,工作班末尿NMAC水平與空氣中DMAC濃度呈良好對數(shù)線性關(guān)系,工作周內(nèi)的任一次班末尿NMAC測定均可用于DMAC職業(yè)接觸評估。根據(jù)回歸方程及我國DMAC職業(yè)接觸限值,推導(dǎo)出DMAC的職業(yè)接觸生物限值為工作班末尿中NMAC水平為15.27 mg/g。
[Abstract]:[objective] to study the relationship between the concentration of dimethyl acetamide (DMA) in workplace and the level of biological monitoring index in occupational population, and to further explore the biological limit of occupational exposure of DMAC. [methods] A survey of labor hygiene was carried out in an enterprise producing 4C4Adiphenyl ether. Urine samples were collected from 32 workers exposed to DMAC on day 1, day 2 and day 5 before and at the end of the shift. The level of methylacetamide (NMAC) in urine was determined by gas chromatography, and the concentration of DMACin in workplace air during working day was collected by individual sampler. The correlation between NMAC level in urine and individual exposure, length of service and age was analyzed by multiple regression analysis, and occupational health monitoring data were collected to analyze the relationship between DMAC exposure concentration and health effect. [results] the weighted average concentration of DMAC in the air for 8 h was 121.32 鹵164.31)mg/m~3(1.30~818.20 mg / m ~ (-3). The DMAC concentration of 26 samples exceeded the national occupational health standard by 20 mg / m ~ (3), and the rate of exceeding the standard was 81.25%. There was no significant difference in the level of NMAC in the urine before and after the shift between different working days (all P 0.05). The results of multivariate regression showed that the level of NMAC in urine of workers exposed to DMACs was positively correlated with the individual exposure concentration of DMAC in the air. There was a positive correlation between the NMAC level in urine and the individual exposure concentration of DMAC in the air. [conclusion] it was found that there was no accumulation of NAMC in urine. There was a good logarithmic linear relationship between the level of NMAC in urine and the concentration of DMAC in air at the end of the working week. The NMAC measurement of urine in any shift during the working week could be used to evaluate the occupational exposure of DMAC. According to the regression equation and the occupational exposure limit of DMAC in China, it was deduced that the biological limit of occupational exposure of DMAC was 15.27 mg / g NMAC level in urine at the end of work shift.
【作者單位】： 上海市疾病預(yù)防控制中心職業(yè)衛(wèi)生與中毒控制科;上海市化工職業(yè)病防治院;
【基金】：基金項目 上海市笫四輪公共衛(wèi)生三年行動計劃重點學(xué)科建設(shè)計劃環(huán)境衛(wèi)生與勞動衛(wèi)生學(xué)(編號:15GWZK0201)
【分類號】：R134

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