【摘要】：近年來,隨著科學(xué)技術(shù)的發(fā)展,一些藥品生產(chǎn)企業(yè)會對某些藥品的生產(chǎn)設(shè)備和生產(chǎn)工藝進(jìn)行了升級改造。但新設(shè)備新技術(shù)新工藝的使用,往往會產(chǎn)生藥品生產(chǎn)過程中危險(xiǎn)化學(xué)品種類、數(shù)量的增多,生產(chǎn)過程的更加復(fù)雜,需要設(shè)備的多樣化以及涉及到危險(xiǎn)化工工藝等危險(xiǎn)因素。這些因素如果不進(jìn)行有效的安全管理,往往會導(dǎo)致事故的發(fā)生,造成經(jīng)濟(jì)損失以及人員傷亡。因此,做好這些藥品生產(chǎn)的安全管理,對于提高經(jīng)濟(jì)效益和市場競爭力有著很重要的作用。本文以河北M藥業(yè)集團(tuán)對氨基苯酚生產(chǎn)為例,采用理論分析與案例分析相結(jié)合的方法,在參考學(xué)習(xí)大量安全管理文獻(xiàn)資料的同時(shí),借鑒同行專家研究出的安全管理成果和結(jié)論,通過對該藥品的生產(chǎn)工藝、安全特點(diǎn)以及產(chǎn)品生產(chǎn)過程中的危險(xiǎn)、有害因素分析和研究,在安全管理體系、安全生產(chǎn)標(biāo)準(zhǔn)化、設(shè)備設(shè)施、危險(xiǎn)物料、生產(chǎn)工藝、作業(yè)環(huán)境、儲存方法等方面,提出了在對氨基苯酚生產(chǎn)過程中應(yīng)重點(diǎn)關(guān)注的問題以及做好生產(chǎn)安全管理的相關(guān)意見和建議。同時(shí)也為同類型的醫(yī)藥企業(yè)在產(chǎn)品設(shè)備更新和工藝改造后,如何有效進(jìn)行安全管理方面提供了科學(xué)、合理的借鑒和參考依據(jù),從而幫助這些企業(yè)有效開展生產(chǎn)安全管理工作,遏制和消除各類生產(chǎn)安全事故的發(fā)生,確保生產(chǎn)平穩(wěn)運(yùn)行,促進(jìn)企業(yè)的安全健康發(fā)展。
[Abstract]:In recent years, with the development of science and technology, some pharmaceutical enterprises will upgrade the production equipment and production process of some drugs. However, the use of new equipment, new technology and new technology will often produce dangerous chemicals in the process of drug production, such as the increase in the number of dangerous chemicals, the more complex production process, the need for diversification of equipment and the risk factors involved in dangerous chemical processes and so on. If these factors do not carry on the effective safety management, often will cause the accident to occur, causes the economic loss as well as the casualty. Therefore, it is very important to improve the economic efficiency and market competitiveness of these drugs. Taking the production of p-aminophenol in Hebei M Pharmaceutical Group as an example, this paper uses the method of combining theoretical analysis with case analysis to refer to a large number of safety management documents, and draw lessons from the safety management achievements and conclusions of the peer experts. Through the analysis and research on the production process, safety characteristics, hazard and harmful factors of the product, the safety management system, safety production standardization, equipment and facilities, dangerous materials, production process, working environment, In the storage methods, the paper puts forward some important problems in the production of p-aminophenol, and puts forward some suggestions and suggestions on the safety management of production. At the same time, it also provides scientific, reasonable reference and reference basis for the same type of pharmaceutical enterprises how to effectively carry out safety management after the product equipment renewal and process transformation, so as to help these enterprises to effectively carry out production safety management work. Control and eliminate all kinds of production safety accidents, ensure the smooth operation of production, and promote the safe and healthy development of enterprises.
【學(xué)位授予單位】：天津大學(xué)
【學(xué)位級別】：碩士
【學(xué)位授予年份】：2014
【分類號】：TQ243.2;F426.72;F273

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