【摘要】：目的了解替加環(huán)素及米諾環(huán)素對(duì)Van M型萬(wàn)古霉素耐藥屎腸球菌臨床分離株的體外抗菌活性。方法收集2006—2014年上海地區(qū)臨床分離Van M型萬(wàn)古霉素耐藥屎腸球菌45株;采用PCR擴(kuò)增及測(cè)序確認(rèn)菌種和萬(wàn)古霉素耐藥基因型;測(cè)定替加環(huán)素及米諾環(huán)素等10種抗菌藥物對(duì)Van M型萬(wàn)古霉素耐藥屎腸球菌的MIC。結(jié)果 45株臨床分離株均確認(rèn)為Van M型萬(wàn)古霉素耐藥屎腸球菌;所有菌株對(duì)萬(wàn)古霉素高度耐藥(MIC 128~256 mg/L),對(duì)替考拉寧耐藥率為71.1%。幾乎所有菌株對(duì)左氧氟沙星(100%)和氨芐西林(97.8%)耐藥,對(duì)米諾環(huán)素、慶大霉素和利福平的耐藥率分別為15.6%、64.4%和82.2%,未檢出替加環(huán)素和利奈唑胺耐藥株。結(jié)論替加環(huán)素和米諾環(huán)素對(duì)Van M型萬(wàn)古霉素耐藥屎腸球菌有良好的體外抗菌活性。
[Abstract]:Objective to investigate the in vitro antibacterial activity of tegacycline and minocycline against Van M vancomycin resistant Enterococcus faecalis clinical isolates. Methods 45 strains of Van M vancomycin resistant enterococcus were collected from Shanghai from 2006 to 2014. The strains and vancomycin resistant genotypes were confirmed by PCR amplification and sequencing, and the MIC. of 10 antibiotics, such as tegacycline and minocycline, to Van M vancomycin resistant enterococci were determined. Results 45 clinical isolates were identified as Van M vancomycin resistant enterococcus, and all strains were highly resistant to vancomycin (MIC 128 鈮，

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