新型布尼亞病毒感染病原學(xué)檢測與預(yù)后研究
發(fā)布時間：2019-05-21 18:17
【摘要】：目的通過回顧性分析新型布尼亞病毒感染患者繼發(fā)細(xì)菌或真菌感染,探索高載量新型布尼亞病毒感染與預(yù)后相關(guān)性,為臨床診治危重癥患者提供參考依據(jù)。方法對醫(yī)院2013年9月-2015年9月收治70例發(fā)熱伴血小板減少綜合征病例資料進(jìn)行回顧性分析,比較病程中培養(yǎng)結(jié)果和布尼亞核酸檢測結(jié)果與患者預(yù)后相關(guān)性,數(shù)據(jù)采用SPSS 20.0軟件進(jìn)行統(tǒng)計分析。結(jié)果患者以中老年農(nóng)民為主,多在5~7月份發(fā)病,17.39%患者有明確蜱叮咬史;共分離10株病原菌,以曲霉菌為主,共3株占30.00%;23例布尼亞病毒核酸陽性,其中重癥患者死亡5例,痊愈患者18例。結(jié)論出現(xiàn)感染性休克的患者預(yù)后差,病死率高;在診療過程中,宜采取有效抗感染治療方案和對癥支持治療,尤其對于重癥患者需加強(qiáng)實驗室指標(biāo)的監(jiān)測和病情監(jiān)護(hù)。
[Abstract]:Objective to analyze the secondary bacterial or fungal infection in patients with new Bunia virus infection, and to explore the relationship between high load Bunia virus infection and prognosis, so as to provide reference for clinical diagnosis and treatment of critically ill patients. Methods the data of 70 cases of fever complicated with thrombopenia syndrome treated in hospital from September 2013 to September 2015 were analyzed retrospectively. the correlation between the results of culture and Bunia nucleic acid test and the prognosis of the patients was compared. The data were statistically analyzed by SPSS 20.0 software. Results most of the patients were middle-aged and elderly farmers, most of them occurred from May to July, 17.39% of the patients had a definite history of ticks bite, 10 strains of pathogenic bacteria were isolated, mainly Aspergillus, 3 strains accounted for 30.00%. There were 23 cases of Bunia virus nucleic acid positive, of which 5 cases died and 18 cases were cured. Conclusion the prognosis of patients with septic shock is poor and the fatality rate is high. In the process of diagnosis and treatment, effective anti-infection treatment and symptomatic support treatment should be taken, especially for severe patients, the monitoring of laboratory indexes and condition monitoring should be strengthened.
【作者單位】： 安徽醫(yī)科大學(xué)第二附屬醫(yī)院肝病科;安徽大學(xué)經(jīng)濟(jì)學(xué)院經(jīng)濟(jì)統(tǒng)計系;
【基金】：安徽高校省級自然科學(xué)基金資助項目(KJ2014A107)
【分類號】：R446.5
[Abstract]:Objective to analyze the secondary bacterial or fungal infection in patients with new Bunia virus infection, and to explore the relationship between high load Bunia virus infection and prognosis, so as to provide reference for clinical diagnosis and treatment of critically ill patients. Methods the data of 70 cases of fever complicated with thrombopenia syndrome treated in hospital from September 2013 to September 2015 were analyzed retrospectively. the correlation between the results of culture and Bunia nucleic acid test and the prognosis of the patients was compared. The data were statistically analyzed by SPSS 20.0 software. Results most of the patients were middle-aged and elderly farmers, most of them occurred from May to July, 17.39% of the patients had a definite history of ticks bite, 10 strains of pathogenic bacteria were isolated, mainly Aspergillus, 3 strains accounted for 30.00%. There were 23 cases of Bunia virus nucleic acid positive, of which 5 cases died and 18 cases were cured. Conclusion the prognosis of patients with septic shock is poor and the fatality rate is high. In the process of diagnosis and treatment, effective anti-infection treatment and symptomatic support treatment should be taken, especially for severe patients, the monitoring of laboratory indexes and condition monitoring should be strengthened.
【作者單位】： 安徽醫(yī)科大學(xué)第二附屬醫(yī)院肝病科;安徽大學(xué)經(jīng)濟(jì)學(xué)院經(jīng)濟(jì)統(tǒng)計系;
【基金】：安徽高校省級自然科學(xué)基金資助項目(KJ2014A107)
【分類號】：R446.5
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