發(fā)布時間：2019-04-11 09:38

【摘要】：目的了解住院患者感染金黃色葡萄球菌(SAU)分布與耐藥性,為深入研究金黃色葡萄球菌的致病性和耐藥機(jī)制奠定基礎(chǔ)。方法對2012年1月-2014年12月住院患者98 127份來自血液、胸腹水、尿液、感染灶分泌物/膿腫引流物、術(shù)后引流液、肺泡灌洗液(BALF)、鼻咽拭子和痰液等標(biāo)本進(jìn)行回顧性分析,分析感染SAU的分布及其對常用抗菌藥物耐藥趨勢。結(jié)果 2012年1月-2014年12月住院患者共送檢各類標(biāo)本98 127份,標(biāo)本檢測陽性20 132份,陽性率20.52%;共檢出率SAU 1 053株,檢出率為5.23%;464株來源于合格下呼吸道標(biāo)本,208株來源于感染灶分泌物/膿腫穿刺/引流物,60株來源于鼻咽拭子,分別占44.07%、19.75%、5.70%;SAU主要分布在呼吸科、兒科及ICU,分布率分別為17.19%、15.95%、11.30%;SAU對頭孢曲松、氨芐西林/舒巴坦、四環(huán)素耐藥率波動顯示,差異有統(tǒng)計學(xué)意義(P0.05),對青霉素G、苯唑西林、阿莫西林/克拉維酸鉀、頭孢唑林等耐藥率變化,差異無統(tǒng)計學(xué)意義,未發(fā)現(xiàn)耐萬古霉素、利奈唑胺菌株;3年耐甲氧西林金黃色葡萄球菌(MRSA)檢出率分別為43.30%、38.10%、37.10%,差異無統(tǒng)計學(xué)意義。結(jié)論 SAU在住院患者各系統(tǒng)感染中均占有重要地位;SAU對不同抗菌藥物的耐藥率不同。
[Abstract]:Objective to investigate the (SAU) distribution and drug resistance of Staphylococcus aureus in hospitalized patients, and to lay a foundation for further study on the pathogenicity and drug resistance mechanism of Staphylococcus aureus. Methods from January 2012 to December 2014, 98 127 samples from blood, pleural and ascites, urine, secretions / abscess drainage, postoperative drainage fluid, (BALF), nasopharynx swabs and sputum in alveolar lavage fluid were retrospectively analyzed. To analyze the distribution of SAU infection and the trend of drug resistance to antibiotics in common use. Results from January 2012 to December 2014, 98 127 samples were examined, 20,132 of them were positive, the positive rate was 20.52%, the positive rate of SAU was 1 053, the positive rate was 5.23%, the positive rate was 20.52%, the positive rate was 5.23%. 464 samples from qualified lower respiratory tract, 208 from secretion / abscess puncture / drainage, 60 from nasopharyngeal swabs, accounting for 44.07%, 19.75%, 5.70%, respectively. The distribution rate of SAU in respiratory department was 17.19%, 15.95% and 11.30% in paediatrics and ICU, respectively. The resistance rate of SAU to ceftriaxone, ampicillin / sulbactam and tetracycline was significantly different (P0.05), and the resistance rates to penicillin G, oxacillin, amoxicillin / clavulanate and cefazolin were significantly different. There was no significant difference between the two groups. No vancomycin-resistant or linazosin-resistant strains were found. The (MRSA) detection rates of methicillin-resistant Staphylococcus aureus were 43.30%, 38.10% and 37.10%, respectively. There was no significant difference between the two groups. Conclusion SAU plays an important role in all systemic infections of inpatients, and the resistance rate of SAU to different antimicrobial agents is different.
【作者單位】： 成都市第三人民醫(yī)院暨重慶醫(yī)科大學(xué)附屬成都第二臨床學(xué)院檢驗科;成都市第三人民醫(yī)院暨重慶醫(yī)科大學(xué)附屬成都第二臨床學(xué)院兒科;
【基金】：國家自然基金資助項目(31500077) 四川省科技廳應(yīng)用基礎(chǔ)研究基金資助項目(2013JY0121)
【分類號】：R197.32;R446.5

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